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    ApoA-I inhibits leukocyte adhesion to endothelial cells <i>in vivo</i>. by Scott J. Cameron (838315)

    Published 2015
    “…P-selectin knockout mice (p-selectin<sup>-/-</sup>) do not display leukocyte-to-endothelial cell adhesion after histamine stimulation, validating this as an <i>in vivo</i> acute inflammatory adhesion assay. (B) ApoA-I knockout mice (apoA-I <sup>-/-</sup>) have low plasma HDL concentration compared to WT mice and show increased adhesion of leukocytes to the vascular endothelium <i>in vivo</i> (decreased rolling velocity) compared to WT mice or apoA-I <sup>-/-</sup> mice injected with apo-AI (0.5mg, intraperitoneal) 24 hours before. …”
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