Image9_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image5_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image7_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image11_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image10_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

The human methylome in pancreatic islets from 15 T2D and 34 non-diabetic donors. by Tasnim Dayeh (428020)

“…CpG island: 200 bp (or more) stretch of DNA with a C+G content of >50% and an observed CpG/expected CpG in excess of 0.6. …”

Stimulus-driven Blondel communities proofed that both affected subnetworks were an interconnected system. by Isabel Wank (12475626)

“…<p>(a) RTX administration repressed mainly intra-thalamic connections (size of light blue nodes massively decreased, RTX) within the thalamo-hippocampal community (blue arrows) but enhanced the number of cortical connections (size of pink nodes increased, RTX) within the sensorimotor-association cortex community (pink arrows). …”

sFRP-3 binds EGF <i>in vitro</i>. by Raffaella Scardigli (49421)

“…Absorbance scanning from emission value 505 nm to 540 nm of EGFAlexa488 (green curve). A decreasing of the emission peak (517 nm) is shown in relation to EGFAlexa488/sFRP-3 interaction (red curve). …”

Generation of <i>Nkx2.5-Cre/Foxm1^fl/fl</i> mice and efficiency of Foxm1 deletion. by Craig Bolte (299486)

“…<p>The Cre-LoxP system was utilized to generate a mouse line in which Foxm1 was selectively deleted from myocardial cells (A). …”

Data_Sheet_6_Dynamic Changes in Microbial Composition During Necrotizing Soft-Tissue Infections in ICU Patients.PDF by Michael Thy (10226687)

“…</p><p>Results: Among 100 patients {63% male, 58 years old [interquartile ratio (IQR) 50–68]} admitted for NSTI, 54 underwent reoperation with a median [IQR] delay of 3 (1–7) days. …”

Data_Sheet_1_Dynamic Changes in Microbial Composition During Necrotizing Soft-Tissue Infections in ICU Patients.PDF by Michael Thy (10226687)

“…</p><p>Results: Among 100 patients {63% male, 58 years old [interquartile ratio (IQR) 50–68]} admitted for NSTI, 54 underwent reoperation with a median [IQR] delay of 3 (1–7) days. …”

Table_1_Associations of Pre-Diagnostic Serum Levels of Total Bilirubin and Albumin With Lung Cancer Risk: Results From the Southern Community Cohort Study.pdf by Hyung-Suk Yoon (733818)

“…T1</sub> = 0.70, 95% CI: 0.50-0.98) and among African Americans (OR<sub>T3 vs. …”

DataSheet3_Quantifying Iron Oxide Mineral Contents in Miocene Oceanic Red Beds for the Deep-Sea Oxidation Evolution in the South China Sea.XLSX by Xuan Lyu (12465639)

“…The results show that these samples contain 0.20–1.48% hematite (average 0.50%) and 0.30–2.98% goethite (average 1.20%). Their contents have good linear correlations with color reflectance a* (red) and b* (yellow), respectively, implying that the reddish-brown color of the Miocene oceanic red beds resulted from a mixture of hematite and goethite. …”

Data_Sheet_3_Dynamic Changes in Microbial Composition During Necrotizing Soft-Tissue Infections in ICU Patients.PDF by Michael Thy (10226687)

“…</p><p>Results: Among 100 patients {63% male, 58 years old [interquartile ratio (IQR) 50–68]} admitted for NSTI, 54 underwent reoperation with a median [IQR] delay of 3 (1–7) days. …”

Image_3_High Glucose Level Impairs Human Mature Bone Marrow Adipocyte Function Through Increased ROS Production.TIF by Tareck Rharass (707643)

“…Without inducers, HG condition also led to decreased leptin mRNA level. Importantly, intracellular and extracellular ROS concentrations measured using Amplex Red were significantly raised by 50% under HG exposure. …”

Image_1_Associations of Pre-Diagnostic Serum Levels of Total Bilirubin and Albumin With Lung Cancer Risk: Results From the Southern Community Cohort Study.pdf by Hyung-Suk Yoon (733818)

“…T1</sub> = 0.70, 95% CI: 0.50-0.98) and among African Americans (OR<sub>T3 vs. …”

Image_2_High Glucose Level Impairs Human Mature Bone Marrow Adipocyte Function Through Increased ROS Production.TIF by Tareck Rharass (707643)

“…Without inducers, HG condition also led to decreased leptin mRNA level. Importantly, intracellular and extracellular ROS concentrations measured using Amplex Red were significantly raised by 50% under HG exposure. …”

Supplementary Material for: Sinomenine suppressed keratinocyte proliferation and imiquimod-induced psoriasis-like dermatitis by regulating lncRNA XIST by Xiang S. (13241799)

“…Background: Psoriasis is a chronic inflammatory skin disease. Sinomenine (SIN) has anti-inflammatory and antioxidant effects. …”

Longitudinal change of circulating tumor cell level and its relationship with immune checkpoint inhibitor-based treatment benefits in unresectable, metastatic colorectal cancer pat... by Hua Fan (495346)

“…Meanwhile, CTC count at M2 was decreased versus that at baseline (median (interquartile range): 1.0 (0.0–3.0) versus 3.0 (0.0–5.0)) (<i>p</i> < 0.001). …”

Image_4_High Glucose Level Impairs Human Mature Bone Marrow Adipocyte Function Through Increased ROS Production.pdf by Tareck Rharass (707643)

“…Without inducers, HG condition also led to decreased leptin mRNA level. Importantly, intracellular and extracellular ROS concentrations measured using Amplex Red were significantly raised by 50% under HG exposure. …”