Pathological ion channel alterations generate hyperexcitable cell models. by Jenny Tigerholm (305475)

“…The right column shows the decreased K_A current pathology (50% decrease in K_A conductance). …”

Image_1_Sex-related differences in the response of anti-platelet drug therapies targeting purinergic signaling pathways in sepsis.jpeg by Emmanuel Boadi Amoafo (14045520)

“…Male and female wild-type (WT), P2Y₁₂ knock-out (KO), and P2Y₁ KO mice underwent sham surgery or cecal ligation and puncture (CLP) to induce sepsis. …”

Combined effects of treated domestic wastewater, fly ash, and calcium nitrite toward concrete sustainability by Abushanab, Abdelrahman

“…Test results revealed that TWW slightly decreased concrete compressive and flexural strengths by 5%-12%, whereas it dramatically increased the porosity and chloride permeability by about 40%. …”
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QRT-PCR for 27-hydroxylase and ABCA1 message in NS398-treated THP-1 cells exposed to prostaglandins by Edwin SL Chan (28334)

“…THP-1 human monocytes were exposed to the following conditions represented by the six bars (from left to right): (1) RPMI 1640, (2) NS398 (50 μM), (3) PGE(0.1 μM) + NS398 (50 μM), (4) PGE(0.1 μM) + NS398 (50 μM), (5) PGE(0.1 μM) + PGE(0.1 μM) + NS398 (50 μM), and (6) PGD(14 μM) + NS398 (50 μM) (all 18-hour exposures). …”

MAb 1340 inhibits function of the alternative complement system. by Diana Pauly (170378)

“…The <i>E. coli</i> lysis assay showed comparable inhibitory results with the hemolysis assay. MAb A235 showed a decrease in viable <i>E. coli</i> at concentrations above 1 µg/mL. …”

QRT-PCR for 27-hydroxylase and ABCA1 message in NS398-treated THP-1 macrophages exposed to prostaglandins or TXA by Edwin SL Chan (28334)

“…THP-1 human macrophages were exposed to the following conditions represented by the five bars (from left to right): (1) RPMI 1640, (2) NS398 (50 μM), (3) PGE(0.1 μM) + NS398 (50 μM), (4) PGD(14 μM) + NS398 (50 μM), and (5) TXA(3 μM) + NS398 (50 μM) (24-hour exposures to NS398 alone followed by addition of indicated PG or TXAfor a further 24 hours). …”

Table1_Retrospective Recall of Psychological Distress Experienced During the First COVID-19 Lockdown in Italy: Results From the ALT RISCOVID-19 Survey.doc by Francesca Bracone (12014342)

“…</p><p>Methods: Cross-sectional analysis on 1,880 adults (mean age 48.9 ± 14.5 years) from the web-based ALT RISCOVID-19 survey. …”

<i>trb</i> mutants resist tribendimidine-induced sterility. by Yan Hu (30839)

“…The relative brood sizes of wild-type animals at 50, 100, and 200 µg/mL are respectively 31%, 12%, and 5% of the brood size without toxin. …”

Toxins from the Caribbean sea anemone Bunodeopsis globulifera increase cisplatin-induced cytotoxicity of lung adenocarcinoma cells by Heidi I Monroy-Estrada (5669477)

“…Results Pre-exposure to CV, F1 and F2 fractions increases cisplatin cytotoxicity in human lung adenocarcinoma cells under specific conditions. Exposure to CV at 50 μgmL-1 induced a reduction of approximately 50% in cell viability, while a similar cytotoxic effect was observed when cell culture was exposed to F1 at 25 μgmL -1 or F2 at 50 μgmL-1. …”

The impact of outcome perceptibility on the precision of the estimate of the differential effect of treatment. by Ognjen Arandjelović (295373)

Ivermectin and albendazole withdrawal period in goat milk by Patrícia Silva Santos (6305066)

“…The amount of residues contained in themilk was decreasing in function of time. The mean daily rates of decrease of albendazole residues were 63.34%, 40.18 and 100.0%, from the 2ndto the 4thday, respectively; on the 3rdday after treatment, 50% of the samples showed concentrations ≥ 47.61 μg.mL–1, and on the 4thday, no sample had albendazole residue. …”

Results of Multivariate Regression Analyses. by Jeet Gandhi (262339)

“…The association coefficient is −0.07, which means after adjusting for <i>EGFR</i> mutation and <i>HER2</i> copy number effects, the IC50 will decrease 0.85 fold when <i>EGFR</i> relative copy number increases 1 unit.…”

Over-expression of Fas2 in the wing imaginal disc causes an EGFR-dependent reduction in organ size. by Luis Garcia-Alonso (152388)

“…At right, a clone in the Posterior compartment between vein V and the posterior wing margin (green arrow) causes an abnormal shape due to the reduction in size of the posterior region of the wing, while another clone between veins II and III causes a size decrease in the anterior compartment (green arrow). …”

Uncovering the Epigenetic Contribution of Protein Arginine Methyltransferase 5 (PRMT5) during Zebrafish Cardiomyogenesis by Zakaria, Zain Zaki

“…This was accompanied by a moderate decrease in blood flow (20%), significantly higher decrease in general cardiac output (65%), and reduction in red blood cells count (50%). …”
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Western blot of non-canonical TGFβ signaling pathway. by Marjolijn Renard (526772)

“…<p>(<b>A</b>) Western blot analysis of pERK1/2 (44 kDa band pERK1 and 42 kDa band pERK2) in wild-type (wt) and heterozygous mutant (ht) mice of 6 and 12 months old shows no major increase or decrease of the active (phosphorylated) form of ERK1/2 in these groups compared to total ERK1/2 and β-tubulin. …”

Isomeric Mono-, Di-, and Tri-Bromobenzo-1H-Triazoles as Inhibitors of Human Protein Kinase CK2α by Romualda Wąsik (119538)

“…The decrease in pK_a on halogenation of the peripheral C(4)/C(7) atoms virtually nullifies the gain due to hydrophobic interactions, and does not lead to a decrease in IC₅₀. …”

Effects of Herbicides on the Survival of the Brazilian Native Bee Melipona scutellaris Latreille, 1811 (Hymenoptera: Apidae) by R.C.F. NOCELLI (8075633)

G-CSF knockdown reduces MDSC accumulation. by Jeremy D. Waight (195980)

Supplementary figure 1 by Cass Dedert (12837572)

“…</strong>Primary cortical neurons were incubated in Neurobasal medium containing either 25 mM (control), 50 mM, or 100 mM glucose. After 72 hours of treatment, viability showed a dose-dependent decrease as glucose concentration increased. …”

Necroptosis sensitivity screen in 941 cancer cell lines identifies drivers of necroptosis resistance. by Ayaz Najafov (322631)

“…Note that RIPK1, RIPK3, and MLKL levels decrease in lane 2 because of induction of necroptosis, formation of amyloid-like necrosome structure, and translocation of these proteins into a detergent-insoluble fraction. …”