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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation
منشور في 2025"…The two most effective 15-LOX inhibitors, 2a and 2b, exhibited 69 % and 57 % of quercetin's action, respectively. …"
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A robust experimental-based artificial neural network approach for photovoltaic maximum power point identification considering electrical, thermal and meteorological impact
منشور في 2020"…<p dir="ltr">This paper aims to develop a robust and practical photovoltaic (PV) Maximum Power Point (MPP) identification tool developed using reliable experimental data sets. …"
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12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase
منشور في 2013"…<p dir="ltr">The purpose of the current study was to evaluate the effect of 12/15- lipoxygenase (12/15-LOX) metabolites on retinal endothelial cell (REC) barrier function. …"
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Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation
منشور في 2025"…The two most effective 15-LOX inhibitors, <b>2a</b> and <b>2b</b>, exhibited 69 % and 57% of quercetin's action, respectively. …"
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Stochastic Programming for Hub Energy Management Considering Uncertainty Using Two-Point Estimate Method and Optimization Algorithm
منشور في 2023"…This has been done using a new meta-heuristic algorithm, improved artificial rabbits optimization (IARO). …"
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A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase
منشور في 2015"…Fluorescein angiography and retinal albumin leakage showed a significant decrease in retinal hyperpermeability in streptozotocin-induced diabetic mice lacking 12/15-LOX compared with diabetic WT mice. …"
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Effect of Hypoxia on Maximal Fat Oxidation Rate During Incremental Cycling : Relationship to the Gas Exchange Threshold
منشور في 2024"…A 25% decrease in MFO in HYPO (0.25 ± 0.08g.min<sup>-1</sup>) compared to NORM (0.35 ± 0.08g.min-1; <i>P</i> < 0.001; <i>d</i> =1.24) was observed. …"
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Anabolic steroids-induced delirium
منشور في 2020"…Psychiatric aspects are of particular importance and include psychosis, delirium, mania, depression, and aggression. We describe the case of a young gentleman who was managed as a case of androgenic steroid induced delirium.…"
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Predictors of mortality and morbidity in critically ill COVID‐19 patients: An experience from a low mortality country
منشور في 2022"…Factors independently associated with mortality included older age ([OR]; 2.3 [95% CI; 1.92–2.75] for each 10-year increase in age, <i>p</i> < 0.001), chronic kidney disease (OR; 1.9 [95% CI; 1.02–3.54], <i>p</i> = 0.04), active malignancy (OR; 6.15 [95% CI; 1.79–21.12], <i>p</i> = 0.004), lower platelet count at ICU admission (OR; 1.41 [95% CI; 1.13–1.75] for each 100 × 103/µl decrease, <i>p</i> = 0.002), higher neutrophil-to-lymphocyte ratio at admission (OR; 1.01 [95% CI; 1–1.02] for each 1- point increase, <i>p</i> = 0.016), higher serum ferritin level at admission (OR; 1.05 [(95% CI; 1.02–1.08] for each 500 µg/L increase, <i>p</i> = 0.002), and higher serum bilirubin level at admission (OR; 1.19 [95% CI; 1.04–1.36] for each 10 μmol/L increase, <i>p</i> = 0.01). …"
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Old subjects with sepsis in the emergency department: trend analysis of case fatality rate
منشور في 2019"…We aimed to assess the case fatality rate (CFR) and its predictors in subjects with sepsis admitted to a general Italian hospital from 2009 to 2016, stratified by risk score.…"
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Nonlinear Control of Brushless Dual-Fed Induction Generator With a Flywheel Energy Storage System for Improved System Performance
منشور في 2025"…After optimization, the SMC settling time was significantly reduced from 0.7 seconds to 19.97 milliseconds, achieving a 96.9% improvement in response speed, while its steady-state error decreased from 0.48 to 0.06, marking an 87.5% reduction in tracking error. …"
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Non-diabetic ketoacidosis secondary to primary hyperthyroidism
منشور في 2022"…To the best of our knowledge, our case is the third report of NDKA related to thyrotoxicosis.…"
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Light chain amyloidosis presenting with autoimmune hepatitis-primary sclerosing cholangitis overlap syndrome
منشور في 2020"…Primary biliary cirrhosis or primary sclerosing cholangitis (PSC) with autoimmune hepatitis (AIH) overlap syndrome is a very unusual presentation of systemic amyloidosis and to the best of our knowledge, not reported before. We present a rare case of a 46-years-old female with systemic amyloidosis secondary to AL amyloidosis manifesting primarily as nephrotic syndrome and AIH-PSC overlap syndrome.…"
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The effect of Ramadan focused education on patients with type 2 diabetes: A systematic review and meta-analysis
منشور في 2020"…It also identifies a lack of head to head studies and limited observational studies with adequately assessed end-points.…"
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