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Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function
Published 2024“…We recently showed that four arrhythmogenic CaM mutations (N98I, D132E, D134H, and Q136P) significantly reduce the binding of CaM to RyR2. …”
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Anti-angiogenic effect of nano-formulated water soluble kaempferol and combretastatin in an in vivo chick chorioallantoic membrane model and HUVEC cells
Published 2023“…Morphometric analysis of CAM showed that treatment with nano-formulated water-soluble kaempferol and combretastatin caused a substantial decrease in density, vessel network, branch points, and nets of CAM blood vessels. …”
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Insights Into SARS-CoV-2 S1-RBD-ACE2 Interaction Using Computational Tools and Membrane Microarray Platform
Published 2024“…To uncover the impact of these mutations, we first performed molecular dynamics (MD) simulations with the wild type (WT) and the N501Y mutant ACE2-S1-RBD complex, revealing an interfacial ‘freezing’ in the N501Y mutant. …”
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Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma
Published 2020“…In treated rat carcinomas, we found significant caspase-3, Bax, and Bax/Bcl-2 expression increases; on the other side, a significant down-regulation of Bcl-2, Ki67, CD24, ALDH1, and EpCam expressions and MDA levels. When compared to control specimens, evaluation of epigenetic alterations in rat tumor cells in vivo showed significant dose-dependent decrease in lysine methylation status of H3K4m3 and H3K9m3 and dose-dependent increase in lysine acetylation in H4K16ac levels (H4K20m3 was not changed) in treated groups. …”
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Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov...
Published 2023“…MethodThe study comprised fully-vaccinated naïve individuals (VN; n = 596) who had no history of SARS-CoV-2 infection, and received two doses of either BNT162b2 or mRNA-1273, and naturally infected individuals who had a documented history of SARS-CoV-2 infection and no vaccination record (NI cohort; n = 218). …”
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Data-Efficient Wheat Disease Detection Using Shifted Window Transformer: Enhancing Accuracy, Sustainability, and Global Food Security
Published 2025“…To enhance interpretability, Grad-CAM visualization techniques were applied, confirming model reliability. …”
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Postprandial lipaemia 10 and 34 hours after playing football: Does playing frequency affect the response?
Published 2019“…The aim of the present study was to examine whether playing affects postprandial TG during 1.5 day of reduced activity. Eighteen males were randomly allocated to perform either 1 (1FOOT; n = 9; age = 33.0 ± 5.0 yrs; body mass index = 24.2 ± 3.6 kg/m<sup>2</sup>) or 3 (3FOOT) consecutive days of 60-min 5 vs 5 football (n = 9; age = 32.8 ± 5.2 yrs; body mass index = 26.2 ± 4.1 kg/m<sup>2</sup>) matches across a 5-day study period. …”
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Retinal imaging based glaucoma detection using modified pelican optimization based extreme learning machine
Published 2024“…Furthermore, we have utilized seven Explainable AI methodologies: Vanilla Gradients (VG), Guided Backpropagation (GBP ), Integrated Gradients ( IG), Guided Integrated Gradients (GIG), SmoothGrad, Gradient-weighted Class Activation Mapping (GCAM), and Guided Grad-CAM (GGCAM) for interpretability examination, aiding in the advancement of dependable and credible automation of healthcare detection of glaucoma.…”
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Crumpled MXene nanosheets for sensing of ascorbic acid in food, biological fluids, and erythrocytes in-vitro microenvironment
Published 2023“…The as-prepared crumpled MXene was coated over a glassy carbon electrode (GCE) and used to determine AA successfully via cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV) with a linear concentration range of 300 μM to 0.005 μM with a detection limit (LOD) of 2 nM (2.8 % RSD and S/N = 3). The developed electrochemical sensor was used to determine the AA in various actual samples such as juice, urine, serum, and erythrocytes spiked with AA with excellent recoveries in the 94–103 % range. …”
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Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs
Published 2022“…</p><h3>Results</h3><p dir="ltr">Patients on ACEi (<i>n</i> = 57), ARB (<i>n</i> = 68), BB (<i>n</i> = 15), or CCB (<i>n</i> = 30) in this study had mild (<i>n</i> = 76), moderate (<i>n</i> = 76), or severe (<i>n</i> = 52) COVID-19. …”
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Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov...
Published 2023“…</p><p><br></p><h3>Method</h3><p dir="ltr">The study comprised fully-vaccinated naïve individuals (VN; n = 596) who had no history of SARS-CoV-2 infection, and received two doses of either BNT162b2 or mRNA-1273, and naturally infected individuals who had a documented history of SARS-CoV-2 infection and no vaccination record (NI cohort; n = 218). …”
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Predictors of prolonged hospitalization among geriatric trauma patients using the modified 5-Item Frailty index in a Middle Eastern trauma center: an 11-year retrospective study
Published 2025“…</p><h3>Results</h3><p dir="ltr">There were 17,600 trauma hospitalizations with a mean age of 32 ± 15 years between 2010 and 2021; of them, 9.2% were geriatrics at ≥ 55–64 years (n = 935) and ≥ 65 years (<i>n</i> = 691). …”
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The Effect of Experimental Recuperative and Appetitive Post-lunch Nap Opportunities, With or Without Caffeine, on Mood and Reaction Time in Highly Trained Athletes
Published 2021“…After PSD, POMS score decreased after CAF (<i>p</i> < 0.001; d = 2.38; Δ% = 66.97) and CAF+N20 (<i>p</i> < 0.001; <i>d</i> = 1.68; Δ% = 46.68). …”
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Nonlinear Control of Brushless Dual-Fed Induction Generator With a Flywheel Energy Storage System for Improved System Performance
Published 2025“…The system is further enhanced with Optimal Torque Control (OTC) and Maximum Power Point Tracking (MPPT) to maximize wind energy extraction. In the second stage, a Synergetic Control (SC) strategy is implemented for FESS management, integrated seamlessly into the overall system. …”
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Deep Learning for Dynamic Wildlife Monitoring: A Real-Time Approach
Published 2025“…The parameters of the fine-tuned YOLOv11 decreased by 30% relative to the previous version, resulting in a very small model size of 5.5 MB and reduced processing time. …”
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Occurrence and removal characteristics of phthalate esters from bottled drinking water using silver modified roasted date pits
Published 2022“…Adsorption efficiency of the various adsorbents was investigated by using different adsorbent masses (0.05 g, 0.10 g, and 0.15 g) and temperature (30 °C, 50 °C, and 60 °C). …”
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