Gluconeogenic gene <i>fbp-1</i> expression is required for healthspan extension under dietary restriction. by Brian Onken (86790)

“…<p>(A) Survival curves of long-lived, dietary-restricted <i>eat-2(ad1116)</i> mutants treated with RNAi against gluconeogenic gene <i>fbp-1</i>. …”

Image 1_Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5 × FAD mice.jpeg by Huan Chen (6545)

“…Overexpression of METTL16 led to an increase in overall m⁶A methylation levels, furthermore, overexpression of either METTL16 or MAT2A enhanced learning and memory in 5 × FAD mice, elevated the expression levels of postsynaptic density 95 (PSD95) and synaptophysin (Syp), increased dendritic spine density, and decreased the accumulation of Aβ_1–42 in the hippocampus. …”

Bone marrow exhibits decreased cellularity and increased apoptosis, but no change in global cytosine methylation, following ablation of the <i>Cxxc1</i> gene. by Kristin T. Chun (668653)

Ectopic Expression of a Maize Hybrid Down-Regulated Gene <i>ZmARF25</i> Decreases Organ Size by Affecting Cellular Proliferation in <i>Arabidopsis</i> by Chuan Li (158692)

“…Moreover, overexpression of <i>ZmARF25</i> led to reduced organ size in <i>Arabidopsis</i>, which was mainly due to the decrease in cell number, not cell size. In addition, the cell proliferation related genes <i>AtANT, AtGIF1</i> and <i>AtGRF5</i> were down-regulated in 35S::<i>ZmARF25</i> transgenic lines. …”

Interaction fractions of photons with (a) ¹H, (b) ¹²C, (c) ¹⁴N and (d) ¹⁶O within cell layer for 1 MeV incident photons. by Mehrdad Shahmohammadi Beni (796228)

MiR-132-3p was downregulated in TGF-<i>β</i>1 stimulated Met-5A cells and miR-132-3p mimics and miR-132-3p inhibitor transfected Met-5A cells. by Yangyang Yin (14323701)

Subjects:

Algal oil and Meganol D decreased early vascular lesions and upregulate plasma SPM in APOE^-/- mice. by Agua Sobrino (368634)

Down-regulation of pol III activity in hypoxia is not due to a decrease in the abundance of TFIIIB, TFIIIC or pol III subunits by Isabelle Ernens (13462)

Disrupting Glycolysis-promoting Genes Extends <i>C</i>. <i>elegans</i> Healthspan, Whereas High Glucose and Gluconeogenic Gene Disruptions Shorten Healthspan. by Brian Onken (86790)

“…Conversely, animals treated with RNAi directed against gluconeogenic genes <i>fbp-1</i> and <i>pck-2</i> have lowered median survival (a 10.94% decrease for <i>fbp-1</i> disruptions and a 21.88% decrease for <i>pck-2</i> disruptions) and exhibit lower survival relative to controls (<i>P</i> < 0.0001 for both <i>fbp-1</i> and <i>pck-2</i> disruptions, Log-rank). …”

The healthspan effects of glycolytic and gluconeogenic disruptions are absent in the <i>age-1</i> insulin signaling mutant background. by Brian Onken (86790)

“…The harmful effects of <i>pck-2</i> RNAi (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.g001" target="_blank">Fig 1D</a>) are absent in <i>age-1</i> mutants: the survival curve is not altered with <i>pck-2</i> RNAi treatment (n.s., not significant, Log-rank), and median survival is actually increased by 5.13%.…”

Decreased F4/80⁺ macrophages in the presence of PLD inhibitors using IF microscopy of lung sections. by Karen M. Henkels (3350273)

“…<p>Lung sections from MDA-MB-231 xenotransplanted mice were incubated with a FITC-F4/80 IgG antibody specific for TAMs (<b>A-D</b>) or biological duplicates from independent experiments (<b>A’-D’</b>) or with an isotype control-FITC IgG antibody (<b>E-H</b>). …”

Decreased hypotaurine levels within cells lacking the ADO gene in U251 cells. by Hong Tian (169626)

Decreased Ly6G⁺ neutrophils in the presence of PLD inhibitors using IF microscopy of lung sections. by Karen M. Henkels (3350273)

“…<p>Lung sections from MDA-MB-231 xenotransplanted mice were incubated with a TRITC-Ly6G antibody specific for TANs (<b>A-D</b>) or biological duplicates from independent experiments stained with Ly6G-R-PE (<b>A’-D’</b>) TANs (<b>A-D</b>) or biological duplicates from independent experiments stained with Ly6G-R-PE or with an isotype control-R-PE IgG antibody (<b>E-H</b>). …”

Table_1_Decrease in Admissions and Change in the Diagnostic Landscape in a Newborn Care Unit in Northern Ghana During the COVID-19 Pandemic.DOC by Alhassan Abdul-Mumin (5986151)

“…</p><p>Methods: This is a cross-sectional study carried out on neonates admitted to NICU between March 1st to August 31st, 2019 (pre-COVID-19 era) and March 1st to August 31st, 2020 (COVID-19 era). …”

Fig 5 - by Jianhua Su (1571566)

Data_Sheet_1_Elevated temperature and decreased salinity impacts on exogenous Vibrio parahaemolyticus infection of eastern oyster, Crassostrea virginica.zip by Omario M. A. Ricketts (16450914)

“…Specifically, we examined whether an increase in water temperature and/or decrease in salinity would impair oyster resistance to V. parahaemolyticus, a human food and waterborne pathogen. …”

Graphs showing the mean temperature increase at the positions with the highest mean temperature increase for the MIPS (A) and MONO (B) systems and three drilling protocols (DP1, DP... by Marsel Ganeyev (21453399)

Blockade of CB₁ receptors does not prevent the anandamide-induced decrease in locomotor activity and rearing. by Adriaan W. Bruijnzeel (2605954)

“…<p>Rats were treated with rimonabant (5 mg/kg, ip) and anandamide (10 mg/kg, ip) and horizontal (A) and vertical beam breaks (B) were assessed in the small open field. …”

Ectopic BIR efficiency is decreased by cis-acting factors including transcription and heterochromatin of the template chromatid. by Tannia Uribe-Calvillo (12902576)

Silencing of SphK1, but not SphK2, decreases HPAEC migration by S1P in wound healing ECIS assay. by Evgeny V. Berdyshev (307465)