Diverse stress conditions trigger a rapid and dramatic decrease in miR-520b-3p and a corresponding increase in ATF5 mRNA over time in HeLa cells. by Kari A. Gaither (9046190)

In separate sheets, the excel spreadsheet contains the numerical data and statistical analysis for Figs 1C, 1E, 6B, 6C, 6D, 6E, 7A, 7C, 7D, 7E, 7F, 7G, 7H and 7I; S12A, S12B, S12D,... by Zhiyuan Li (205620)

Disrupting Glycolysis-promoting Genes Extends <i>C</i>. <i>elegans</i> Healthspan, Whereas High Glucose and Gluconeogenic Gene Disruptions Shorten Healthspan. by Brian Onken (86790)

“…Trials with 5 and 13 day old animals also showed impaired older age locomotion in 4% glucose (Supplemental <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.s002" target="_blank">S1A and S1B Fig</a>). …”

Table_2_Decrease of Clone Diversity in IgM Repertoires of HBV Chronically Infected Individuals With High Level of Viral Replication.pdf by Binbin Hong (9989819)

“…Taken together, our findings provide a better understanding of the antibody repertoires of HBV chronically infected individuals.…”

Table_4_Decrease of Clone Diversity in IgM Repertoires of HBV Chronically Infected Individuals With High Level of Viral Replication.pdf by Binbin Hong (9989819)

“…Taken together, our findings provide a better understanding of the antibody repertoires of HBV chronically infected individuals.…”

Table_3_Decrease of Clone Diversity in IgM Repertoires of HBV Chronically Infected Individuals With High Level of Viral Replication.pdf by Binbin Hong (9989819)

“…Taken together, our findings provide a better understanding of the antibody repertoires of HBV chronically infected individuals.…”

Gluconeogenic gene <i>fbp-1</i> expression is required for healthspan extension under dietary restriction. by Brian Onken (86790)

“…<p>(A) Survival curves of long-lived, dietary-restricted <i>eat-2(ad1116)</i> mutants treated with RNAi against gluconeogenic gene <i>fbp-1</i>. …”

Excess glucose availability negatively impacts healthspan of young and old animals; conversely, the benefits of disrupting glycolysis do not include extended maximal lifespan. by Brian Onken (86790)

“…Exposure to excess glucose results in significant decreases in swimming rates in young animals (day 5 from hatching; <i>P</i> = 0.0004, unpaired t test). n = 40 animals per condition from a single trial; error bars represent SEM; *** <i>P</i> < 0.001. …”

Dietary Restriction Induces Gluconeogenic Gene <i>pck-2</i> Expression via DAF-16, and <i>pck-2</i> Expression is Needed for DR-associated Healthspan Benefits. by Brian Onken (86790)

“…Elevated gluconeogenic activity (dependent on DAF-16-promoted PCK-2 expression) acts in a feed-forward capacity to further enhance the gluoconeogenic pathway and may inhibit glycolysis/insulin signaling to promote/maintain DAF-16 signaling and healthy metabolism (inhibition represented by a dashed line).…”

Thalidomide treatment inhibits growth in RAMEC but not in RAMEC transfected with a dominant negative mutant of CUL5 (^S730ACUL5) cDNA. by Bryan Kunkler (5204327)

The healthspan effects of glycolytic and gluconeogenic disruptions are absent in the <i>age-1</i> insulin signaling mutant background. by Brian Onken (86790)

“…The harmful effects of <i>pck-2</i> RNAi (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.g001" target="_blank">Fig 1D</a>) are absent in <i>age-1</i> mutants: the survival curve is not altered with <i>pck-2</i> RNAi treatment (n.s., not significant, Log-rank), and median survival is actually increased by 5.13%.…”

Effect of vitamin D derivatives on the proliferation and the differentiation of ATDC5 cells. by Yoshihisa Hirota (616015)

Spatial training decreases endogenous PTEN ubiquitination and <i>Pten</i> cKO mice show impaired spatial learning and memory. by Wei-Lun Hsu (1756123)

“…Endogenous PTEN ubiquitination level is decreased in Nedd4 siRNA-transfected rats (t_1,6 = 5.92, <i>p</i> = 0.001). …”

Table_5_A Temporal Diversity Analysis of Brazilian Begomoviruses in Tomato Reveals a Decrease in Species Richness between 2003 and 2016.docx by Tadeu Araujo Souza (9214526)

“…Nineteen genome-sized geminivirus sequences were assembled, but only 17 were confirmed by PCR. In the G1 library, five begomoviruses and one capula-like virus were detected, but the number of identified viruses decreased to three begomoviruses in the G2 and G3 libraries. …”

Image_5_A Temporal Diversity Analysis of Brazilian Begomoviruses in Tomato Reveals a Decrease in Species Richness between 2003 and 2016.tif by Tadeu Araujo Souza (9214526)

“…Nineteen genome-sized geminivirus sequences were assembled, but only 17 were confirmed by PCR. In the G1 library, five begomoviruses and one capula-like virus were detected, but the number of identified viruses decreased to three begomoviruses in the G2 and G3 libraries. …”

MicroRNA-146a-5p enhances T helper 17 cell differentiation via decreasing a disintegrin and metalloprotease 17 level in primary sjögren’s syndrome by Xiaoyan Wang (8433)

PrP^C, but not CNTN5, is decreased in sporadic AD. by Isobel J. Whitehouse (331843)

5-fluorouracil decreases rates of persistent and reappearing actinic keratoses: The VAKCC Trial by Moniyka Sachar (9399032)

An ATM-specific inhibitor decreases HBoV1 infection of HAE-ALI. by Xuefeng Deng (138723)

The 5’SS motif decreases mRNA stability and promotes nuclear retention. by Eliza S. Lee (715538)

“…(D) To determine whether the <i>V5-His</i> sequence promotes the degradation of a subset of newly synthesized mRNAs the ratio of <i>c-ftz-Δi</i> and <i>c-ftz-Δi-V5-His</i> were plotted over time. …”