Search alternatives:
teer decrease » mean decrease (Expand Search), greater decrease (Expand Search)
nn decrease » _ decrease (Expand Search), mean decrease (Expand Search), gy decreased (Expand Search)
b decrease » _ decrease (Expand Search), b1 decreased (Expand Search), ob decreased (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
16 b » 16 _ (Expand Search), 1 b (Expand Search), 6 b (Expand Search)
teer decrease » mean decrease (Expand Search), greater decrease (Expand Search)
nn decrease » _ decrease (Expand Search), mean decrease (Expand Search), gy decreased (Expand Search)
b decrease » _ decrease (Expand Search), b1 decreased (Expand Search), ob decreased (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
16 b » 16 _ (Expand Search), 1 b (Expand Search), 6 b (Expand Search)
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Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the...
Published 2023“…The optimal compound <b>J27</b> decreased the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC<sub>50</sub> = 0.22 μM) through the NF-κB/MAPK pathway. …”
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Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the...
Published 2023“…The optimal compound <b>J27</b> decreased the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC<sub>50</sub> = 0.22 μM) through the NF-κB/MAPK pathway. …”
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Dietary Restriction Induces Gluconeogenic Gene <i>pck-2</i> Expression via DAF-16, and <i>pck-2</i> Expression is Needed for DR-associated Healthspan Benefits.
Published 2020“…Elevated gluconeogenic activity (dependent on DAF-16-promoted PCK-2 expression) acts in a feed-forward capacity to further enhance the gluoconeogenic pathway and may inhibit glycolysis/insulin signaling to promote/maintain DAF-16 signaling and healthy metabolism (inhibition represented by a dashed line).…”
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Differential abundance of selected KEGG pathways at the 16<sup>th</sup> week.
Published 2024Subjects: -
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Disrupting Glycolysis-promoting Genes Extends <i>C</i>. <i>elegans</i> Healthspan, Whereas High Glucose and Gluconeogenic Gene Disruptions Shorten Healthspan.
Published 2020“…Trials with 5 and 13 day old animals also showed impaired older age locomotion in 4% glucose (Supplemental <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.s002" target="_blank">S1A and S1B Fig</a>). …”
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General procedures for the synthesis of the key compounds 7a, b, 9, and 10.
Published 2023Subjects: -
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