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STRUCTURAL AND FUNCTIONAL APPROACHES TOWARD ACTIVITY RESTORATION OF NOVEL CYSTATHIONINE BETA-SYNTHASE MUTATIONS
Published 2024“…This study investigates the impact of five pathogenic CBS missense mutations [c.1006C>T (p.R336C), c.689T>A (p.L230Q), 215A>T (p.K72I), c.707C>A (p.T236N), and c.457G>A (p.G153R)] identified in homocystinuria patients and appeared to be resistant to pyridoxine treatment on the biochemical and biophysical properties of CBS protein. …”
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423
Acute and chronic toxicity assessments of 17β-estradiol (E2) and 17α-ethinylestradiol (EE2) on the calanoid copepod Acartia clausi: Effects on survival, development, sex-ratio and...
Published 2022“…In contrast, embryonic stage revealed high vulnerability to E2 and EE2 acute effects. Embryos showed non-monotonic dose-response and hatching success was significantly reduced at low realistic concentrations of E2 (0.005, 0.5, and 5 μg L-1) and EE2 (0.05 and 5 μg L-1).Survival, development and sex ratio of A. clausi to EE2 exposure at 1 and 100 μg L-1 were also determined during a life cycle experiment. …”
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424
Influence of shelf-life duration on mechanical, thermal and shape recovery motion derivatives of shape memory polyurethane
Published 2024“…The results indicated that tensile and flexural strength decreased by 35.16 % and 29.3 % respectively, from S1 to S10. …”
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Pharmacologic inhibition of hypoxia-inducible factor (HIF)-hydroxylases ameliorates allergic contact dermatitis
Published 2019“…Background When an immune cell migrates from the bloodstream to a site of chronic inflammation, it experiences a profound decrease in microenvironmental oxygen levels leading to a state of cellular hypoxia. …”
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426
Trends in prevalence of depression and anxiety symptoms and effects of sociodemographic variables before and after the first wave of COVID-19 in Qatar
Published 2022“…The data for 2020/21 showed a 35.1% and 29.2% decrease in depression and anxiety symptoms scores compared to pre-pandemic years (2017/2018) after adjusting for sociodemographic factors. …”
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427
Phenolic contents-based assessment of therapeutic potential of Syzygium cumini leaves extract
Published 2019“…The leaf extract also demonstrated an analgesic effect in rabbits as indicated by the decrease in writhing (12.2 ± 1.7 control vs. 3.7 ± 0.6 treated) and anti-inflammatory activity in rabbits paw with a protection against inflammation of 64.1 ± 2.4%. …”
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428
Toxic Effect Of Lannate On Cellular Defence System In Erythrocyte Of Rat
Published 1996“…It has been observed that there was a decrease in the activities of superoxide dismutase and glutathione reductase after 1/2 and 16 hour of Lannate addition. …”
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429
Thermo-economic assessment of forward osmosis as pretreatment to boost the performance and sustainability of multi-effect distillation for seawater desalination
Published 2022“…If high-performing and cost-effective membranes are used, the product cost could be reduced 33 % (5.1 $/m3).…”
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430
Calmodulin Mutations Associated with Congenital Cardiac Disease Display Novel Biophysical and Biochemical Characteristics
Published 2018“…In contrast, in the presence of Ca2+, there was a significant decrease in the stability of the five proteins following the order CaMWT> CaMN98I > CaMD132E > CaMQ136P > CaMD134H. …”
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431
Tobacco control in the Eastern Mediterranean region: implementation progress and persisting challenges
Published 2022“…Tobacco use is the leading cause of preventable mortality worldwide, projected to claim 1 billion lives in the twenty-first century.1 Tobacco prevalence rates are expected to decrease across all the WHO regions by 2025 as a result of tobacco control efforts. …”
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In patients with Chronic Heart Failure Which Polypharmacy Pheno-groups are associated with adverse health outcomes? (Polypharmacy Pheno-groups and Heart failure outcomes)
Published 2023“…Conversely, patients with non-heart failure-related polypharmacy had increased risks of ICU admissions (aOR=1.78, 95% CI: 1.13 – 2.70). …”
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436
Adult appendicitis score versus Alvarado score: A comparative study in the diagnosis of acute appendicitis
Published 2023“…It requires proper management to decrease mortality and morbidity. Clinical scoring systems for diagnosing AA aimed to decrease the use of radiological scans and the rate of negative appendectomies (NA). …”
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437
Origanum Syriacum Inhibits Proliferation, Migration, Invasion and Induces Differentiation of Human Aortic Smooth Muscle Cells
Published 2014“…Cardiovascular diseases (CVDs) are still the number one cause of morbidity and mortality both in Qatar and worldwide. A major risk factor of CVDs is atherosclerosis, the hardening of blood vessels caused by decreased diameter and formation of plaque. …”
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438
Gas Driven Fracture during Gas Production using HeleShaw Cell
Published 2018“…The cell consists of two transparent acrylic sheets that are separated by a small gap. The gap between the two sheets is maintained using filter sheets that have a thickness of 1/16 in. (1.6 mm) at the boundaries. …”
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439
Flight Scheduling in the Airspace
Published 2016“…The mathematical model has been solved using CPLEX 12.6 and the scatter search has been coded using C language under Microsoft Visual Studio v12 environment. The tests were conducted under a Windows 7 machine with an Intel Core i7 and 8 GB of RAM. …”
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440
Caffeine use or napping to enhance repeated sprint performance after partial sleep deprivation: Why not both?
Published 2021“…Purpose: To compare the effect of a 20-minute nap opportunity (N20), a moderate dose of caffeine (CAF; 5 mg·kg-1), or a moderate dose of caffeine before N20 (CAF+N) as possible countermeasures to the decreased performance and the partial sleep deprivation-induced muscle damage. …”
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