Image_3_A Novel Therapeutic Mechanism of Imipridones ONC201/ONC206 in MYCN-Amplified Neuroblastoma Cells via Differential Expression of Tumorigenic Proteins.TIF by Sarra El-Soussi (11228799)

“…The protein expression of tumorigenic NMYC, Sox-2, Oct-4, FABP5, and HMGA1 significantly decreased 48 h post-drug treatment, whereas cleaved PARP1/caspase-3 and γH2AX increased 72 h post-drug treatment, compared with vehicle-treated cells in the MYCN-amplified IMR-32 cell line. …”

Metabolomics reveals that vine tea (<i>Ampelopsis grossedentata</i>) prevents high-fat-diet-induced metabolism disorder by improving glucose homeostasis in rats by Wenting Wan (2736208)

“…</p><p>Methods</p><p>Sprague Dawley (SD) rats were divided into five groups: a group given normal rat chow and water (control group); a group given an HFD and water (HFD group); a group given an HFD and Pioglitazone (PIO group), 5 mg /kg; and groups given an HFD and one of two doses of VT: 500 mg/L or 2000 mg/L. …”

Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors by Mohamed A. Zeidan (21099628)

“…In a pilocarpine-induced paradigm, <i>in vivo</i> assessments showed decreased seizure severity and susceptibility with delayed seizure onset and diminished intensity. …”

Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors by Mohamed A. Zeidan (21099628)

“…In a pilocarpine-induced paradigm, <i>in vivo</i> assessments showed decreased seizure severity and susceptibility with delayed seizure onset and diminished intensity. …”

Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors by Mohamed A. Zeidan (21099628)

“…In a pilocarpine-induced paradigm, <i>in vivo</i> assessments showed decreased seizure severity and susceptibility with delayed seizure onset and diminished intensity. …”

Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors by Mohamed A. Zeidan (21099628)

“…In a pilocarpine-induced paradigm, <i>in vivo</i> assessments showed decreased seizure severity and susceptibility with delayed seizure onset and diminished intensity. …”

Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors by Mohamed A. Zeidan (21099628)

“…In a pilocarpine-induced paradigm, <i>in vivo</i> assessments showed decreased seizure severity and susceptibility with delayed seizure onset and diminished intensity. …”

Schematic diagram of soil sample collection. by Xianyong Wang (22601067)

“…Soil organic carbon and organic matter levels tended to increase on day 5 post-fertilization but generally decreased by day 10, with more pronounced declines observed in low-rate treatments (e.g., 1F). …”

Image 5_Mitochondria-derived reactive oxygen species induce over-differentiation of neural stem/progenitor cells after non-cytotoxic cisplatin exposure.jpeg by Felipe A. Bustamante-Barrientos (15206413)

“…Inhibition of mitochondrial ROS production reduced neuronal and glial differentiation but did not restore self-renewal or cell cycle progression. A decrease in extracellular acidification and lactate production indicated a shift from glycolysis to mitochondrial respiration.…”

Generation of 70Z/3 overexpressing cell lines. by Jeffrey L. Kurkewich (3044211)

Medians +95% Confidence intervals of measures of glycaemia at each visit among patients with TB and DM during TB treatment (Tijuana, Ciudad Juarez, Reynosa, Guadalupe and Zapopan,... by Martín Castellanos-Joya (630597)

Investigation of a Pathway for Water Delivery in Photosystem II Protein by Molecular Dynamics Simulation by Koji Ogata (494313)

“…In an attempt to assess the validity, the MD simulation of the D1-D61A mutant is performed, comparing the distribution of water molecules near the Mn₄O₅Ca cluster. …”

Investigation of a Pathway for Water Delivery in Photosystem II Protein by Molecular Dynamics Simulation by Koji Ogata (494313)

“…In an attempt to assess the validity, the MD simulation of the D1-D61A mutant is performed, comparing the distribution of water molecules near the Mn₄O₅Ca cluster. …”

Arid3B regulates essential B cell developmental genes. by Jeffrey L. Kurkewich (3044211)

Decreased Th2 and increased Th1 cytokines in LPMCs and MLNs from <i>Trichuris muris–</i>infected mice residing outdoors compared to laboratory conditions at 3 weeks p.i. by Jacqueline M. Leung (120235)

Relative abundance of the phyla of dominant bacteria based on 16S rRNA gene amplicon sequencing. by Melissa S. Shinfuku (19942206)

Sodium Carboxymethyl Starch Films with Enhanced Cross-Linking, Electrical, and Mechanical Properties via Supercritical-Assisted Modification by Mingge Wang (16859159)

“…Mechanically, Young’s modulus decreased to 35.5% of its original value (from 203.50 to 71.15 MPa), while the elongation at break increased 5-fold (from 11.5 to 56.7%), transitioning CMS-Na from a rigid, brittle material to a ductile, flexible one. …”

Sodium Carboxymethyl Starch Films with Enhanced Cross-Linking, Electrical, and Mechanical Properties via Supercritical-Assisted Modification by Mingge Wang (16859159)

“…Mechanically, Young’s modulus decreased to 35.5% of its original value (from 203.50 to 71.15 MPa), while the elongation at break increased 5-fold (from 11.5 to 56.7%), transitioning CMS-Na from a rigid, brittle material to a ductile, flexible one. …”

Sodium Carboxymethyl Starch Films with Enhanced Cross-Linking, Electrical, and Mechanical Properties via Supercritical-Assisted Modification by Mingge Wang (16859159)

“…Mechanically, Young’s modulus decreased to 35.5% of its original value (from 203.50 to 71.15 MPa), while the elongation at break increased 5-fold (from 11.5 to 56.7%), transitioning CMS-Na from a rigid, brittle material to a ductile, flexible one. …”

Ectopic <i>Lxn</i> expression increases apoptosis of A20 cells. by Yi Liu (36759)

“…BrdU and 7AAD staining and flow cytometric analysis was used for detecting different phases of the cell cycle (G0/G1, S, G2/M) and apoptotic (A) and necrotic (N) population. A representative flow cytometric file from Day 5 of culture is shown. …”