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    Schematic representation of the molecular mechanism by which iRF decreases the aggressiveness of B16F10 cells. by Daisy Machado (288559)

    Published 2013
    “…In addition, cell survival mediator, mTOR, was less active as well as Src kinase, an important key player of cell invasion. As we have shown previously in other cancer cell lines, iRF also induced B16F10 cells death by apoptosis since the expression of anti-apoptotic protein Bcl-2 is reduced. …”