Deregulation of CREB Signaling Pathway Induced by Chronic Hyperglycemia Downregulates NeuroD Transcription by In-Su Cho (174455)

“…Here, we show that β-cell dysfunctions occurring in chronic hyperglycemia are not caused by simple inhibition of CREB activity but rather by the persistent activation of CREB due to decreases in protein phophatase PP2A. When freshly isolated rat pancreatic islets were chronically exposed to 25 mM (high) glucose, the PP2A activity was reduced with a concomitant increase in active pCREB. …”

Data_Sheet_1_Post-implementation knowledge retention of stroke: the lasting influence of FAST Heroes.docx by Emilia Orologa (19768545)

“…</p>Methods<p>Forty-five participants engaged in the present study (35 women, 10 men; 72.8§5.3) and completed an adapted version of the FAST Heroes Stroke Preparedness Questionnaire via phone calls.…”

Data Sheet 1_Effect of sheep placenta extract on D-galactose-induced aging mouse.docx by Shan He (121220)

“…</p>Results<p>In the serum of aging mice treated with SPE, the levels of antioxidant function such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) were notably higher compared to those in the blank group, whereas malondialdehyde (MDA) levels decreased. We revealed that SPE alleviated the changes in gut microbiota caused by aging in mice, with a significant decrease in the Firmicutes/Bacteroidetes (F/B) ratio in the gut. …”

Data_Sheet_1_The Role of Cognitive Control in Age-Related Changes in Well-Being.pdf by Ayano Yagi (9136775)

“…In contrast, in those who had a higher level of cognitive control ability, mental fatigue showed a steady decrease with age even after their mid-60s. …”

Investigation of chemical or enzymatic treatment of iRBCs on eKnobs. by Mathias Diehl (11530195)

“…F) Concatenation of all iRBC data from the experiments in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1009969#ppat.1009969.g005" target="_blank">Fig 5B</a> also shows a decrease in surface exposed in Δ<i>PFA</i> across all experiments. …”

Development of peptide biosensor for the detection of dengue fever biomarker, nonstructural 1 by Ji Hong Kim (7430216)

“…Potential affinity peptides specific for NS1 were chosen according to the dynamic current decrease in SWV experiments. Using circular dichroism, the molar ellipticity of peptides (DGV BP1–BP5) was determined, indicating that they had a mostly similar in random coil structure, not totally identical. …”

Table 1_StSN2 enhances tuber formation in potato via upregulating of the ABA signaling pathway.pdf by Shifeng Liu (219646)

“…The research results show that deletion of the StSN2 gene led to a delay of about 14 days in the formation of potato stolons, and a decrease in yield by 20-30%. …”

Enrichment and stability of synaptoneurosomes. by Celia Williams (265997)

“…<p>Microscopy: A) Nuclear contamination of the homogenate (2 µl smears) (DAPI fluorescence) decreases after sequential passage through mesh screens with B) the post- 10 µm screen synaptoneurosome pellet (100 µl volume) still retaining a few nuclei (Bar = 20 µm). …”

Image1_Survey of in vitro fertilization add-ons in Japan (Izanami project).tif by N. Shionoya (19815414)

“…A total of 18 add-ons were assessed, and 96.5% (423/438) of facilities used at least one add-on. …”

Collaborative approach of individual participant data of prospective studies of de-escalation in non-immunosuppressed critically ill patients with sepsis by Antonio Gutiérrez-Pizarraya (3823534)

“…<p><b>Background</b>: There is a concern to conduct de-escalation in very sick patients.…”

DataSheet1_Synthesis and biological evaluation of the novel chrysin prodrug for non-alcoholic fatty liver disease treatment.ZIP by Ruiming Zhang (3555281)

“…<p>Background: Chrysin (5,7-dihydroxyflavone) is a natural flavonoid that has been reported as a potential treatment for non-alcoholic fatty liver disease (NAFLD). …”

DataSheet2_Synthesis and biological evaluation of the novel chrysin prodrug for non-alcoholic fatty liver disease treatment.docx by Ruiming Zhang (3555281)

“…<p>Background: Chrysin (5,7-dihydroxyflavone) is a natural flavonoid that has been reported as a potential treatment for non-alcoholic fatty liver disease (NAFLD). …”

Longitudinal serum nAb mapping. by Tysheena P. Charles (3385586)

“…Red shading indicates a log fold reduction of 0.5log10 of greater; green shading indicates a log fold increase of 05.log10 or greater. …”

Influenza-Like-Illness and Clinically Diagnosed Flu: Disease Burden, Costs and Quality of Life for Patients Seeking Ambulatory Care or No Professional Care at All by Joke Bilcke (262673)

“…The disease and economic burden were similar for ambulatory ILI patients, irrespective of whether they received a clinical diagnosis of flu. On average, they experienced 5–6 symptoms over a 6-day period; required 1.6 physician visits and 86–91% took medication. …”

Temporal Trends and Outcomes of Transcatheter versus Surgical Aortic Valve Replacement in Patients with Prior Myocardial Infarction by Ayman Elbadawi (4788270)

“…</p> <p><b>Results</b><b>:</b> Among 24,090 hospitalizations with prior MI undergoing isolated AVR, 58.5% underwent TAVR. Over the study period, there was an increase in the proportion of patients undergoing TAVR and a decrease in patients undergoing SAVR (P_trend<0.001). …”

Comparison of the major phyla of the gut microbiota before and after smoking cessation. by Luc Biedermann (139959)

“…Whereas the intervention group revealed a significant increase in fractions of <i>Firmicutes</i> and <i>Actinobacteria</i> and a decrease in fractions of <i>Proteobacteria</i> and <i>Bacteroidetes</i>, the microbiota of the control groups remained rather stable. …”

Cell growth, cell viability and programmed cell death following oseltamivir treatment. by Joana T. de Oliveira (718565)

“…<p>Cell growth assessed with Trypan blue (A) or with the MTS assay (B) and programmed cell death (C) were evaluated in CMA07 and CMT-U27 cells following treatment with oseltamivir phosphate (0.305 μM, 3.05 μM, 30.5 μM and 305 μM) or PBS as control. …”

MuSK patient IgG4 or IgG1-3 do not induce endocytosis of MuSK. by Inga Koneczny (481353)

“…(B) Staining was scored by two individuals as described in methods, and the scores were normalised to the score at 0 hours for each condition. A slight decrease in staining was observed for cells incubated at 37°C, and pre-fixed cells also showed this reduction. …”

Supplementary Material for: Improved Control of Secondary Hyperparathyroidism in Hemodialysis Patients Switching from Oral Cinacalcet to Intravenous Etelcalcetide, Especially in No... by Xipell M. (6276968)

“…The adherent group (62%) also showed a trend to lower iPTH levels reaching statistical significance after 5 months of follow-up. …”

Superior segmental optic nerve hypoplasia: differential diagnosis with glaucoma by Alexis Galeno Matos (4893577)