Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Chemical Inhibition of eEF1A-1 Peptide Elongation Activity Decreases Palmitate-Induced Cell Death. by Alexandra M. Stoianov (759321)

Decreased tumorigenicity of A549 cells <i>in vivo</i> with reduced IQGAP3 expression. by Ying Yang (24175)

Genes whose expression was decreased in RASMC subjected to Na⁺,K⁺-ATPase inhibition. by Svetlana V. Koltsova (321381)

Fig 5 - by Zeenat A. Shyr (12107048)

VDR-dependent transcriptional activity of vitamin D derivatives in ATDC5 cells and analysis of the effect of binding to DBP. by Yoshihisa Hirota (616015)

“…<p>(A) Concentration dependence of the effects of vitamin D derivatives on VDR-dependent transcriptional activity of <i>CYP24A1</i> in ATDC5 cells. …”

Table_1_A T3SS Regulator Mutant HY9901 ΔaraC of Vibrio alginolyticus Decreased the Expression of HopPmaJ and Provided Protection to Danio rerio as a Live-Attenuated Vaccine.xls by Junlin Wang (4029803)

“…The swimming ability of ΔaraC decreased and exhibited a 2,600 times reduction in virulence to zebrafish. …”

The actin nucleator Cobl decreases significantly in the ipsilateral hemisphere and in the primary motorcortex (M1) during the first hours after ischemic stroke induced by MCAO. by Yuanyuan Ji (455424)

Decreased recruitment of pDCs and CD8⁺ T lymphocytes and higher recruitment of neutrophils to the lung of infected ChemR23-deficient mice. by Benjamin Bondue (153816)

Data_Sheet_1_Early decrease of ventilatory ratio after prone position ventilation may predict successful weaning in patients with acute respiratory distress syndrome: A retrospecti... by Zhichang Wang (2560528)

“…VR responders were defined as patients showing a decrease in VR of greater than or equal to 0.037 from the baseline to within 4 h after prone. …”

Novel Intermetallic Compound UFe₅Si₃:  A New Room-Temperature Magnet with an Original Atomic Arrangement by David Berthebaud (1476517)

Subjects:

Transcriptomics Points-of-Departure (tPODs) to Support Hazard Assessment of Benzo[<i>a</i>]pyrene in Early-Life-Stage Rainbow Trout by Alper James Alcaraz (20977320)

“…RBT were exposed from 1 to 28 days post-hatch (dph) to 0.079, 0.35, 1.5, 7.4, and 29 μg/L (28 d time weighted average measured) B[<i>a</i>]P, as well as 0.05% dimethyl sulfoxide and water only controls. …”

Transcriptomics Points-of-Departure (tPODs) to Support Hazard Assessment of Benzo[<i>a</i>]pyrene in Early-Life-Stage Rainbow Trout by Alper James Alcaraz (20977320)

“…RBT were exposed from 1 to 28 days post-hatch (dph) to 0.079, 0.35, 1.5, 7.4, and 29 μg/L (28 d time weighted average measured) B[<i>a</i>]P, as well as 0.05% dimethyl sulfoxide and water only controls. …”

Transcriptomics Points-of-Departure (tPODs) to Support Hazard Assessment of Benzo[<i>a</i>]pyrene in Early-Life-Stage Rainbow Trout by Alper James Alcaraz (20977320)

“…RBT were exposed from 1 to 28 days post-hatch (dph) to 0.079, 0.35, 1.5, 7.4, and 29 μg/L (28 d time weighted average measured) B[<i>a</i>]P, as well as 0.05% dimethyl sulfoxide and water only controls. …”

Transcriptomics Points-of-Departure (tPODs) to Support Hazard Assessment of Benzo[<i>a</i>]pyrene in Early-Life-Stage Rainbow Trout by Alper James Alcaraz (20977320)

“…RBT were exposed from 1 to 28 days post-hatch (dph) to 0.079, 0.35, 1.5, 7.4, and 29 μg/L (28 d time weighted average measured) B[<i>a</i>]P, as well as 0.05% dimethyl sulfoxide and water only controls. …”

Transcriptomics Points-of-Departure (tPODs) to Support Hazard Assessment of Benzo[<i>a</i>]pyrene in Early-Life-Stage Rainbow Trout by Alper James Alcaraz (20977320)

“…RBT were exposed from 1 to 28 days post-hatch (dph) to 0.079, 0.35, 1.5, 7.4, and 29 μg/L (28 d time weighted average measured) B[<i>a</i>]P, as well as 0.05% dimethyl sulfoxide and water only controls. …”

Transcriptomics Points-of-Departure (tPODs) to Support Hazard Assessment of Benzo[<i>a</i>]pyrene in Early-Life-Stage Rainbow Trout by Alper James Alcaraz (20977320)

“…RBT were exposed from 1 to 28 days post-hatch (dph) to 0.079, 0.35, 1.5, 7.4, and 29 μg/L (28 d time weighted average measured) B[<i>a</i>]P, as well as 0.05% dimethyl sulfoxide and water only controls. …”

Transcriptomics Points-of-Departure (tPODs) to Support Hazard Assessment of Benzo[<i>a</i>]pyrene in Early-Life-Stage Rainbow Trout by Alper James Alcaraz (20977320)

“…RBT were exposed from 1 to 28 days post-hatch (dph) to 0.079, 0.35, 1.5, 7.4, and 29 μg/L (28 d time weighted average measured) B[<i>a</i>]P, as well as 0.05% dimethyl sulfoxide and water only controls. …”

CC-1⁺ immunostained cell numbers decrease by 2 days after TBI and return to control levels by 5 weeks. by Krista A. Dent (709531)

“…Panels show contralateral (Contra) and ipsilateral (Ipsi) external capsule (EC) at (A,B) 2 days (2d), (C,D) 2 weeks (2w) and (E,F) 5 weeks (5w) (G) In the external capsule numbers of CC-1⁺ oligodendrocytes were decreased by 2d after injury, remained decreased at 2 weeks and returned to normal levels by 5 weeks. …”

Time-dependent decreases in beclin-1 (A), Atg5 (B), and SIRT1 (C) protein expression in N2a cells exposed to exogenous Aβ1–42 (10μ μM). by Hye Rin Lee (616252)