Image2_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.TIF by Ádám István Horváth (15443678)

“…Then, SZV-1287 (20 mg/kg/day) or its vehicle was injected intraperitoneally over a 21-day period.</p>Results<p>MIA induced remarkably decreased thresholds of weight bearing and paw withdrawal, alterations in the tibial and femoral structures (reactive sclerosis, increased trabeculation, and cortical erosions), histopathological damage (disorganized cartilage structure, hypocellularity, decreased matrix staining and tidemark integrity, and increased synovial hyperplasia and osteophyte formation), and changes in the astrocyte and microglia density in the lumbar spinal cord. …”

Adiponectin Modulates Oxidative Stress-Induced Autophagy in Cardiomyocytes by Eric E. Essick (435031)

“…H₂O₂ induced LC3I to LC3II conversion by a factor of 3.4±1.0 which was abrogated by pre-treatment with APN by 44.5±10%. …”

Development, optimization, and characterization of microbially triggered <i>Mimosa pudica</i> gum–chitosan polyelectrolyte complex for colon-targeted drug delivery by Samridhi Kurl (21426143)

“…A species distribution profile was constructed using the pKa values of both polymers, and polyelectrolyte complexes (PECs) were prepared at a pH value of 5.25 ± 0.10. …”

Supplementary Material for: The prevalence and spontaneous closure of ventricular septal defects the first year of life by Pihl C. (10280378)

“…After one year 83.5% (607 of 727) of all VSDs had closed spontaneously, resulting in a decrease of prevalence from 3.3% at birth to 0.5% in one-year old children. …”

Role of the Apoptosome in Snap-Action C3 Activation by John G Albeck (268792)

“…Orange dotted line indicates the region where [XIAP]₀ = [Smac]₀ + [apoptosome]₀; numbered circles and cyan arrows indicate the positions of the indicated conditions. Point 1a corresponds to the baseline model, in which either Smac or Apaf-1 knockdown leads to a decrease in <i>f</i>, while point 1b corresponds to the baseline model with 5-fold higher Smac, in which Apaf-1 depletion does not reduce <i>f</i>.…”

Spatial mapping of EC spontaneous activity reveals reduced activation in W and SD vs. LE. by Alejandro Peinado (758770)

“…<p>A significant decrease in the overall intensity (<b>A</b>) of spontaneous events is apparent in W and SD slices. …”

Annual estimated costs of PEP vaccination per clinic and savings from different pricing strategies. by Katie Hampson (110989)

“…Costs increase and savings decrease when 0.5 mL vials are used, as illustrated in <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000982#pntd-0000982-g003" target="_blank">Figure 3</a>.…”

Expression of antioxidant proteins is altered in cystic fibrosis. by Junnan Chen (270183)

“…Blue protein names indicate a decrease, while red names indicate an increase in expression in CF.…”

The fraction of cooperators for different <i>ω</i> and <i>γ</i> based on different behavioral updating. by Xiaochen He (455300)

“…It increases as <i>ω</i> increases when <i>γ</i> > 0.5, but decreases as <i>ω</i> increases when <i>γ</i> < 0.5.…”

Table2_Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease.DOCX by Sofia Schaeffer (20379954)

“…HC 45.4 min vs. 21.3 min, p = 0.0004), and decreased sleep efficiency (MASLD vs. HC 86.5% vs. 92.8%, p = 0.0008) compared with HC despite comparable sleep duration. …”

Table1_Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease.DOCX by Sofia Schaeffer (20379954)

“…HC 45.4 min vs. 21.3 min, p = 0.0004), and decreased sleep efficiency (MASLD vs. HC 86.5% vs. 92.8%, p = 0.0008) compared with HC despite comparable sleep duration. …”

DataSheet3_Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease.PDF by Sofia Schaeffer (20379954)

“…HC 45.4 min vs. 21.3 min, p = 0.0004), and decreased sleep efficiency (MASLD vs. HC 86.5% vs. 92.8%, p = 0.0008) compared with HC despite comparable sleep duration. …”

DataSheet2_Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease.PDF by Sofia Schaeffer (20379954)

“…HC 45.4 min vs. 21.3 min, p = 0.0004), and decreased sleep efficiency (MASLD vs. HC 86.5% vs. 92.8%, p = 0.0008) compared with HC despite comparable sleep duration. …”

DataSheet4_Significant nocturnal wakefulness after sleep onset in metabolic dysfunction–associated steatotic liver disease.PDF by Sofia Schaeffer (20379954)

“…HC 45.4 min vs. 21.3 min, p = 0.0004), and decreased sleep efficiency (MASLD vs. HC 86.5% vs. 92.8%, p = 0.0008) compared with HC despite comparable sleep duration. …”

Figure S1 - Amyloid Beta Resistance in Nerve Cell Lines Is Mediated by the Warburg Effect by Jordan T. Newington (223389)

“…<p><b>Treatment with oxamate or DCA decreases cell viability in Aβ resistant cells.</b> A significant decrease in cell viability in both PC12 (<b>A</b>) and B12 (<b>B</b>) resistant lines was observed after 48 hr concomitant exposure to Aβ (20 µM) and 20 mM oxamate (ox), a chemical inhibitor of LDHA, or Aβ (20 µM) and 2.5 mM dichloroacetate (DCA), a chemical inhibitor of PDK1 (*P<0.01; **P<0.05). …”

Identification of proteins that are differentially expressed in the activated T cells. by Wei-Yun Sheng (261744)

“…<p>Activation of T cells was done by cultivating PBL in the presence of PHA at 5 µg/ml for 1–3 days. The protein extracts from untreated controls (panels A and B) or PHA-treated cells (panels C and D) were electro-focused in a pH 4–7 (panels A and C) or in a pH 6–11 (panels B and D) IPG strip for the 1^st dimension and then separated in a 10% SDS-PAGE for the 2^nd dimension. …”

Video_2_Recovery from cold-induced mitochondrial fission in endothelial cells requires reconditioning temperatures of ≥ 25◦C.WMV by Leonard Quiring (14048349)

“…Networks of tubular mitochondria similar to control cells only re-appeared at 37◦C. ATP content decreased at 4◦C from 3.6 ± 0.4 to 1.6 ± 0.4 nmol/10⁶ cells and decreased even further when rewarming cells to 10◦ and 15◦C. …”

Video_1_Recovery from cold-induced mitochondrial fission in endothelial cells requires reconditioning temperatures of ≥ 25◦C.WMV by Leonard Quiring (14048349)

“…Networks of tubular mitochondria similar to control cells only re-appeared at 37◦C. ATP content decreased at 4◦C from 3.6 ± 0.4 to 1.6 ± 0.4 nmol/10⁶ cells and decreased even further when rewarming cells to 10◦ and 15◦C. …”

Data_Sheet_1_Physical Exercise Exacerbates Acute Kidney Injury Induced by LPS via Toll-Like Receptor 4.PDF by Talita Guerreiro Rodrigues Húngaro (9133691)

“…In the training groups, the animals exercised 5×/week in a treadmill, 60 min/day, for 4 weeks (60% of max. velocity). …”

Image1_Evaluation and Selection of the Inhaler Device for Treprostinil Palmitil Inhalation Powder.pdf by Helena Gauani (12357712)

“…The FPD, an estimate of the respirable dose, varied between 61.0 and 70.6% of the loaded TP dose for all four devices with the 8 and 16 mg TPIP capsule dose. For the 32 mg TPIP capsule dose, the FPD remained above 61.0% for the high and ultra-high resistance devices but decreased to 48.5 and 52.6% for the low and medium resistance devices, respectively. …”