Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

The Immunologic Effects of Mesalamine in Treated HIV-Infected Individuals with Incomplete CD4+ T Cell Recovery: A Randomized Crossover Trial by Ma Somsouk (283498)

“…<div><p>The anti-inflammatory agent, mesalamine (5-aminosalicylic acid) has been shown to decrease mucosal inflammation in ulcerative colitis. …”

RETRACTED ARTICLE: MicroRNA-3194-3p inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by decreasing Wnt/β-catenin signaling through targeting BC... by Bowen Yao (1835059)

“…<p>We, the Editors and Publisher of the journal <i>Artificial Cells, Nanomedicine, and Biotechnology</i>, have retracted the following article:</p> <p>Bowen Yao, Yazhao Li, Liang Wang, Tianxiang Chen, Yongshen Niu, Qingguang Liu & Zhikui Liu (2019) MicroRNA-3194-3p inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by decreasing Wnt/β-catenin signaling through targeting BCL9. …”

Decreased pulmonary cell inflammatory response in FI-A2 and G-A2 peptide vaccinated mice after RSV challenge. by Gertrud U. Rey (501694)

Pharmacological inhibition of EGFR decreases reduces a subset of the inflammatory response at day 2 post-infection. by Marc Swidergall (185453)

Image5_Decreasing incidence and mortality of lung cancer in Hungary between 2011 and 2021 revealed by robust estimates reconciling multiple data sources.TIFF by Gabriella Gálffy (177759)

“…Up until the COVID-19 pandemic, lung cancer incidence was decreasing by 3.18% (2.1%–4.3%) yearly in men, while there was no significant decrease in women. …”

Uptake and Population-Level Impact of Expedited Partner Therapy (EPT) on <i>Chlamydia trachomatis</i> and <i>Neisseria gonorrhoeae</i>: The Washington State Community-Level Randomi... by Matthew R. Golden (136790)

“…We conducted a stepped-wedge, community-level randomized trial to determine whether a public health intervention promoting EPT could increase its use and decrease chlamydia test positivity and gonorrhea incidence in women.…”

Pharmacological inhibition and/or siRNA silencing of EP2 receptor in EP2S cells decrease claudin-4 expression. by Manigandan Lejeune (458492)

Flowchart of the analysis steps and methods used in the study (see details in sections 2.1 to 2.5). by Juan David Gutiérrez (6511763)

Fig 5 - by Frank Rattay (127304)

Subjects:

Fig 5 - by Ina Jahreis (11752073)

The PittII Msf-KO strain has decreased survival in macrophages. by Jennifer M. Kress-Bennett (3179382)

SinV infection causes a decrease in Neuro 2a cells number and viability. by Leandro Silva da Costa (327641)

Downregulation of CIP2A leads to decrease of phosphorylated Akt in lung cancer cells. by Liang Ma (37793)

Fig 5 - by Matthew C. Kochem (18476069)

“…Plasma glucose, insulin, and glucagon were measured before, during, and after OGTTs up to 120 minutes post-prandially. We also assessed individual participants’ sweet taste responses to sucralose and their sensitivities to lactisole sweetness inhibition. …”

Walking path. by Saori Miyagishima (14593506)

Subjects:

Results of regression analysis performed for age. by Saori Miyagishima (14593506)

Subjects:

Computational analysis of pediatric ventricular assist device implantation to decrease cerebral particulate embolization by ThuyTien Nguyen (775693)