Immunostaining of lungs from a control mouse and a mouse infected with SARS-CoV-2. by Germán Ricardo Magaña-Ávila (18446799)

Decreased Serum Level of miR-146a as Sign of Chronic Inflammation in Type 2 Diabetic Patients by Lucy Baldeón R. (674016)

“…<div><p>Background</p><p>There is increasing evidence that chronic inflammation is an important determinant in insulin resistance and in the pathogenesis of type 2 diabetes (T2D). MicroRNAs constitute a newly discovered system of cell regulation and in particular two microRNAs (miR-146a and miR-155) have been described as regulators and biomarkers of inflammation.…”

Rab27A deficiency caused decreased amylase release from isolated acini. by Yanan Hou (736195)

Hemodiafiltration Decreases Serum Levels of Inflammatory Mediators in Severe Leptospirosis: A Prospective Study by Sérgio Aparecido Cleto (3143949)

“…Direct bilirubin and the arterial oxygen tension/fraction of inspired oxygen ratio were significantly higher in the SLED group. We identified the following risk factors (sensitivities/specificities) for mortality in severe leptospirosis: age ≥ 55 years (67%/91%); serum urea ≥ 204 mg/dl (100%/70%); creatinine ≥ 5.2 mg/dl (100%/58%); Acute Physiology and Chronic Health Evaluation II score ≥ 39.5 (67%/88%); Sequential Organ Failure Assessment score ≥ 20.5 (67%/85%); and inspiratory pressure ≥ 31 mmHg (84%/85%).…”

Injection of pNaKtide diminishes PNx-induced decrease in miR-29b-3p expression. by Christopher A. Drummond (3845110)

Algorithm II decreased the false discovery rate (FDR) of our predictions. by Hua Li (46469)

Effects of CGP54626 on NPY^G2WT neurons. by Youjin Oh (3308670)

Hypoxia diminishes DNMT expression and activity and increases expression and activity of TET2 and TET3. by Gregory McCarty (708081)

MMR mutants show decreased mating-type silencing. by Qian Liu (135614)

“…MMR deletion strains (<i>pms1Δ</i>, <i>mlh1Δ</i>, and <i>msh2Δ</i>) displayed white with sectors colonies as compared to WT, indicating a loss of gene silencing at the telomere <i>ADE2</i> reporter. …”

Preserved NSS at 2 and at 24 hours following ischemia and decreased infarct volume in PAR1 KO mice 24 hours following ischemic stroke. by Efrat Shavit-Stein (3186678)

“…(C) Total infarct volume is significantly lower in PAR1 KO mice compared to control (t-test, WT = 6, PAR1 KO = 6). (D) Infarct volume decreases as a function of distance from the ischemic core (slices #5&6). …”

Decrease in gastrin-, histidine decarboxylase-, and somatostatin mRNA due to the <i>H. pylori</i> B128 WT-infection. by Tobias Wiedemann (266622)

Expression of wild-type KCNQ2 but not KCNQ2-A343D or KCNQ2-R353G decreases neuronal excitability. by John P. Cavaretta (606562)

Subjects:

Image_2_Tocilizumab (TCZ) Decreases Angiogenesis in Rheumatoid Arthritis Through Its Regulatory Effect on miR-146a-5p and EMMPRIN/CD147.jpeg by Devy Zisman (11838428)

“…In vitro, the accumulation in the supernatants of the pro-angiogenic factors EMMPRIN, VEGF and MMP-9 was increased by co-culturing the HT1080 fibroblasts and the U937 monocytes, while the accumulation of the anti-angiogenic factor thrombospondin-1 (Tsp-1) and the expression levels of miR-146a-5p were reduced. Transfection of HT1080 cells with the miR-146a-5p mimic, decreased the accumulation of EMMPRIN, VEGF and MMP-9. …”

Inhibition of Hsp90 abolished VEGF-mediated eNOS phosphorylation and decreased NO production and cell viability in BAECs. by Yuanzhuo Chen (802891)

Trex2 expression causes a significant decrease in Distal-EJ, Alt-NHEJ, and SSA, but not HDR. by Nicole Bennardo (93380)

2wT scale-up flow chart. by Phiona Marongwe (6818120)

Mutations in inverted DNA repeats in P_<i>ganS</i> decrease GanR binding. by Cameron Habib (4112590)

Global Land Use Change Impacts on Soil Nitrogen Availability and Environmental Losses by Jing Wang (6206297)

“…However, how global land use changes impact soil N supply and potential N loss remains elusive. By compiling a global data set of 1,782 paired observations from 185 publications, we show that land use conversion from natural to managed ecosystems significantly reduced NNM by 7.5% (−11.5, −2.8%) and increased NN by 150% (86, 194%), indicating decreasing N availability while increasing potential N loss through denitrification and nitrate leaching. …”

Image 5_G. vaginalis increases HSV-2 infection by decreasing vaginal barrier integrity and increasing inflammation in vivo.tif by Nuzhat Rahman (16660416)

“…</p>Methods<p>Mice were inoculated with 10⁷ CFU of the eubiotic bacteria Lactobacillus crispatus, the dysbiotic bacteria G. vaginalis, or PBS as a negative control every 48 h for ten days. On day ten, mice were inoculated with 10⁵ PFU WT HSV-2 333 and survival, pathology, and viral titers were assessed. …”

CD43^-/- septic mice exhibit decreased frequencies of apoptotic CD8⁺ T_EM as compared to WT septic mice. by Katherine T. Fay (2576998)

“…D) There was a significant decrease in apoptosis of CD44^HI CD62L^LO CD8⁺ T_EM in CD43^-/- septic mice compared to WT septic mice (10.3±1.1 vs 17.9±1.9, p = 0.006). …”