Showing 1 - 20 results of 46,308 for search '(( 2 c decrease ) OR ((( 50 ((ns decrease) OR (we decrease)) ) OR ( 5 mg decrease ))))', query time: 0.71s Refine Results
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    Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4‑<i>b</i>]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Assoc... by Mary A. Foutz (20361830)

    Published 2024
    “…Utilizing an oxygen consumption rate assay as a measure of increased cellular respiration, <b>SHO1122147</b> (<b>7m</b>) displayed an EC<sub>50</sub> of 3.6 μM in L6 myoblasts. Pharmacokinetic studies indicated a half-life of 2 h, <i>C</i><sub>max</sub> of 35 μM, and no observed adverse effects at 1,000 mg kg<sup>–1</sup> dose in mice. …”
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    Colon tissue and organoid AJC protein expression is decreased with LD shifting in Per2::Luc mice. by Laura Tran (10924702)

    Published 2021
    “…<p><b>(A)</b> Immunofluorescent staining of E-cadherin (red) in the colon tissue and organoids of shifted and non-shifted Per2::Luc mice. Both demonstrated a significant decrease in E-cadherin in the shifted mice (p<0.05). …”
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    Losartan increased ACE-2 expression, while SARS-CoV-2 spike protein decreased ACE-2 expression in hACE2 brains. by Mackenzi Meier (19251139)

    Published 2024
    “…<p>hACE2 KI mice were treated only with Losartan or intravenously injected with SARS-CoV-2 spike protein (SP, 4 μg/ animal) with or without Losartan (10 mg/kg body weight) for 2 weeks. …”
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