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c decrease » c decreased (Expand Search), rc decreased (Expand Search), _ decreased (Expand Search)
w decrease » we decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
a decrease » _ decreased (Expand Search), _ decreases (Expand Search)
_ decrease » _ decreased (Expand Search)
c decrease » c decreased (Expand Search), rc decreased (Expand Search), _ decreased (Expand Search)
w decrease » we decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
a decrease » _ decreased (Expand Search), _ decreases (Expand Search)
_ decrease » _ decreased (Expand Search)
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(A) Decreasing CaMKII activity by KN-93 (high-3 µmol/L, low-0.5 µmol/L), AIP (high-10 µmol/L, low-2 µmol/L), or decreasing calmodulin activity by W-7 (high-50 µmol/L, low-20 µmol/L) decreases spontaneous AP firing rate (n = 10 for each drug), cAMP (n = 4 for each drug) and ATP (n = 5 for each drug).
Published 2013“…<p>The inactive KN-93 analog, KN-92 (3 µmol/L), has no significant effect on these measurements. A decrease in the spontaneous AP firing rate is associated with a decrease in cAMP that is linked to a decrease in ATP (B). …”
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OCA alone markedly decreases and combined with Gemcitabine or Cisplatin abrogates growth of iCCA xenografts.
Published 2019“…After 4 weeks, when the tumor size was approximately 100 mm<sup>3</sup> (T<sub>0</sub>) mice were treated with OCA (0.03% w/w, 30 mg/kg) alone or combined with Cisplatin (2.4 mg/Kg in 100 μl) or Gemcitabine (1.05 mg/Kg in 100 μl) for 5 additional weeks. a) Results are expressed as percent increase in tumor volume at different time points. …”
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