Systemic candidiasis perturbs copper homeostatic functions in the liver and spleen. by Joanna Mackie (3160335)

“…<i>albicans</i> infection affects the expression of copper homeostatic functions in the liver at transcript (A) and protein (B) levels. As the infection progresses, the abundance of hepatic transcripts for the metal storage protein metallothionein MT1 and the copper-containing ferroxidase ceruloplasmin (CP) increase, while the abundance of the copper importer <i>Ctr1</i> transcript decreases (A). …”

The relative expression level of 10 larval stage specific genes and the larval mortality. by Yubing Wang (225033)

“…The expression profile was examined from egg to adult stage in which the larval stage involved 1^st to 5^th instar larvae and pre-pupa. The results were consistent with their DGE-tag copy numbers as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018644#pone-0018644-t005" target="_blank"><b>Table 5</b></a>, indicating all of them were larval stage specific except DS2 and DS3 which had relatively higher expression level at pupal and adult stages. …”

Table 1_Integrated metabolomic and transcriptomic analysis reveals the biosynthesis mechanism of dihydrochalcones in sweet tea (Lithocarpus litseifolius).xlsx by Shaojun Ling (21979328)

“…Our results revealed an accumulation pattern where DHC levels peaked at stage S3, followed by a sharp decrease at stages S4 and S5, with the exception of sieboldin, which maintained high levels. …”

Data Sheet 1_Integrated metabolomic and transcriptomic analysis reveals the biosynthesis mechanism of dihydrochalcones in sweet tea (Lithocarpus litseifolius).docx by Shaojun Ling (21979328)

“…Our results revealed an accumulation pattern where DHC levels peaked at stage S3, followed by a sharp decrease at stages S4 and S5, with the exception of sieboldin, which maintained high levels. …”

Dissolving microneedle patches for transdermal delivery of paroxetine: <i>in-vitro, ex-vivo</i> studies and its PBPK modeling by Muhammad Sikandar (13449684)

“…</p> <p>MNPs from the optimized formulation successfully created microchannels in rat skin, demonstrated higher permeation than control MNPs with a flux of 146.18 ± 13.42 µg/cm²/h, presented a decrease in lag phase and an increase in drug plasma C_max and AUC compared to PAXIL CR 12.5 mg oral, and showed higher stability in the room and refrigerator conditions.…”

Efficacy of treatment strategies (see Table 1) in preventing subsequent seizures and mortality in STZ rats. by Margaret Maheandiran (503654)

“…B: No significant difference in the incidence of seizures post-treatment in <b>ac+1xglu</b>: 24% (n = 5/21) compared with glu: 55% (n = 12/22) (p<0.05). (*) Significantly lower incidence of seizures post-treatment in <b>ac+multiple glu</b>: 15% (n = 2/14) compared with <b>glu</b>: 55% (n = 12/22) (p<0.02) C: (*) Significantly higher survival rate in <b>ac+multiple glu</b>: 93% (n = 1/14) compared with <b>ac+1xglu</b>: 48% (n = 10/21) (p<0.02). …”

The combined lithostratigraphic and environmental data. by Samuel M. Hudson (2671240)

“…The landscape summary determined from the plant sedaDNA evidence is as follows. 1- Willow woodland within floodplain. 2- More open local landscape with willow in floodplain alongside elm and increased shrubs on terrace edge. 3- Open local landscape with slight decrease in wood/shrub taxa, increases in wetland forbs and first appearance of sedge taxa. 4- Continued open local landscape with increased woodland and graminoid diversity, alongside increasing dryland forb community. 5- Continued open local landscape with clear increases in wet and dry woodland, graminoid and forb diversity. …”

<i>F. scutaria</i> sperm were sensitive to cryoprotectants (no sperm exposed to freezing in any of these treatments). by Mary Hagedorn (319120)

“…<b>C</b>) In contrast, 10% DMSO and PG solutions caused a 30 to 40% decrease in fertilization success for fresh <i>F. scutaria</i>, whereas the 5% solutions did not. …”

Multivariate classifications reveal that individuals who develop bNAbs can be reliably identified by their Fc features at 6 months of infection. by Simone I. Richardson (5076992)

“…Shown are the numbers of individuals for each predicted or observed group with correct classifications indicated in color and misclassifications indicated in white. The 2 bNAb (CAP257 and CAP292) and 2 no-bNAb (CAP88 and CAP228) individuals that were incorrectly classified can be seen in 5A. …”

Phenotypic characterization of pCAME-treated embryos. by Evelien Gebruers (495875)

“…Unless otherwise noted, all treatments were performed at 2- to 4-cell stages. (B) Embryo treated with 140 μM pCAME pulsed 1h at tailbud stage, black arrow denotes ectopic tail; (C) pCAME-treated embryo with 28 μM and with (D) 14 μM pCAME; (E) Embryo treated with 28 μM pCAME; black arrows denote 2 hearts; (F) <i>cmlc2</i>:eGFP embryo treated with 28 μM pCAME; (H) Embryo treated with 28 μM pCAME; black double arrow indicates synophthalmia; (G) and (I) Vehicle-treated control (1% DMSO), black double arrow denotes normal distance between eyes. …”

Administration of anatabine inhibits pro-inflammatory cytokines but does not affect the titer of circulating anti-MOG antibodies. by Daniel Paris (286121)

“…B) Anatabine inhibits the production of pro-inflammatory cytokines in the serum of EAE mice. A significant elevation of TNF-α (Mann-Whitney U = 16.5, Z = −2.22, P = 0.026), IL-1β (Mann-Whitney U = 0, Z = −3.506, P<0.001), IL-6 (Mann-Whitney U = 3, Z = −3.271, P<0.001), IFN-γ (Mann-Whitney U = 16.5, Z = −2.219, P = 0.026) and IL-17 (Mann-Whitney U = 7, Z = −2.958, P = 0.003) was observed in the serum of EAE mice (placebo) compared to control non-immunized mice. …”

Table_1_Biosynthesis of LC-PUFA in Ruditapes philippinarum: Cloning and tissue distribution of Fad and Elovl, and effects of microalgae diets varied in LC-PUFA composition on their... by Kaibin Wu (9753011)

“…However, the R. philippinarum fed with Chlorella sp. exhibited a significant decrease of 18:2n-6 and 18:3n-3 but with a significant increase of their products such as 20:3n-6 and 22:5n-3, indicating that R. philippinarum had a certain capacity for LC-PUFA biosynthesis. …”

Increased PrP accumulation upon FDCs through the course of early prion disease. by Pekka Kujala (79561)

“…L; lymphocyte. Scale bars: (A) 5 µm; (B) 2 µm; (C) 1 µm; (D) 500 nm and (E) 200 nm.…”

Data_Sheet_1_Ecogenomics-Based Mass Balance Model Reveals the Effects of Fermentation Conditions on Microbial Activity.pdf by Jinha Kim (7540949)

“…Based on fermentation product concentrations, methane production, and solid removal, fermentation performance was enhanced under the combined treatments of inoculum heat shock (>60°C), pH 5, 55°C, and short solid retention time (<10 days). …”

Effect of prolactin on the phosphorylation of Ca-dependent PKC isoforms by Silvia Taffetani (77822)

“…</p><p></p> Immunoblots for PKC-α, PKC-β-I, PKC-β-II and PKC-γ in normal female cholangiocytes stimulated for 90 minutes at 37°C with 0.2% BSA (basal value) or prolactin (100 nM) with 0.2% BSA. …”

Table_1_Functional and Morphological Characterization of Small and Large Steroidogenic Luteal Cells From Domestic Cats Before and During Culture.DOCX by Michał M. Hryciuk (7862249)

“…The cells were cultured for 3 or 5 days without gonadotropins. Isolated feline SLC and LLC had different sizes (12 ± 3 μm vs. 34 ± 5 μm, respectively), morphologies (amount of lipid droplets) and behaved differently in culture. …”

Image_1_Functional and Morphological Characterization of Small and Large Steroidogenic Luteal Cells From Domestic Cats Before and During Culture.TIF by Michał M. Hryciuk (7862249)

“…The cells were cultured for 3 or 5 days without gonadotropins. Isolated feline SLC and LLC had different sizes (12 ± 3 μm vs. 34 ± 5 μm, respectively), morphologies (amount of lipid droplets) and behaved differently in culture. …”

Mucoadhesive polymeric films comprising polyvinyl alcohol, polyvinylpyrrolidone, and poloxamer 407 for pharmaceutical applications by Camila Felix Vecchi (9638338)

Table_1_Comparison of prepartum blood parameters in dairy cows with postpartum ketosis and new risk prediction candidates.DOCX by Woojae Choi (14775910)

“…Primiparous KET showed lower carboxylated osteocalcin (cOC) levels and a significant decrease after parturition. …”

Table_1_Comparison of prepartum blood parameters in dairy cows with postpartum ketosis and new risk prediction candidates.DOCX by Woojae Choi (14775910)

“…Primiparous KET showed lower carboxylated osteocalcin (cOC) levels and a significant decrease after parturition. …”