Intranasal administration of telmisartan decreases amyloid plaques and CD11b staining in the cortex and hippocampus of 4-month old 5XFAD mice. by Nofar Torika (3169497)

L-NAME but not D-NAME decreased iNOS expression of the intestinal mucosa, hepatic bacteria clearance, and IL-1β as well as TNF-α expression of the Kupffer cells in STZ-DM mice. by Shu-Han Lin (4020353)

Subjects:

Overexpression of GRK2 and β-arrestin-2 decreases cell surface GPR3 expression. by Katie M. Lowther (427408)

“…Densitometric values for surface GPR3 was divided by densitometric values for total GPR3 and normalized to GAPDH to compare the amount of GPR3 at the surface vs. total GPR3 expression. (*) indicates a significant decrease in surface/total GPR3 expression as a result of GRK2 and β-arrestin-2 overexpression. …”

Silencing <i>cullin-1/5</i> decreased mRNA and protein expression of NF-κB dependent cytokines. by Attinder Chadha (11414273)

Subjects:

LiCl administered via 0.5% LiCl food pellets for 4 wks does not increase markers for autophagy in <i>Gfap-</i>R236H/+ mice. by Christine M. LaPash Daniels (796881)

The influence of S226 phosphorylation on the interaction between SNX5 and SNX1 or SNX2. by Nao Itai (5954666)

Subjects:

After being phagocytosed by hMDM <i>S. aureus</i> strain Newman decreasingly persists intracellularly for several days until a burst of growth on day 6. by Malgorzata Kubica (19847)

m⁵C modified sites contributes to HBV replication in cccDNA-like system. by Jiangpeng Feng (9287738)

Subjects:

Molecular and Structural Analysis of Mosaic Variants of Penicillin-Binding Protein 2 Conferring Decreased Susceptibility to Expanded-Spectrum Cephalosporins in <i>Neisseria gonorrh... by Joshua Tomberg (1345956)

“…Finally, we investigated the effects of a mutation (A501V) currently found only in nonmosaic <i>penA</i> alleles on decreased susceptibility to ceftriaxone and cefixime, with the expectation that this mutation may arise in mosaic alleles. …”

Methamphetamine exposure decreases midbrain neuronal activity via a D₂ receptor mechanism. by Douglas R. Miller (7406591)

Higher baseline PV rates decrease the need for interneuron specialization. by Joram Keijser (12475353)

Decreased expression of adipogenesis-related genes by baicalein in early stage of adipogenesis. by Yukari Nakao (3138795)

“…<p>A, Expression levels of the adipogenic and lipogenic genes. 3T3-L1 cells (undifferentiated cells: U; <i>white columns</i>) were differentiated into adipocytes (differentiated cells: D) for 6 days in DMEM in the absence (<i>gray columns</i>) or presence (50 μM; <i>black columns</i>) of baicalein during days 0–2 or 0–6. …”

Decreased numbers of motor neurons in Tc1 and Dp(16)1Yey mice. by Sheona Watson-Scales (586942)

TUDCA decreases ER stress in HOX neonatal rat lungs. by Kirkwood A. Pritchard Jr. (13449794)

“…(<b>C</b>) In IHC stain, P-IRE1α levels are decreased (40.8±3.5 A.U. …”

Ni causes a decrease in membrane sterols in A549 lung epithelial cells. by Amber R. Matha (19681603)

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”