Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Kcnk5b activity induces IP₃R-mediated Ca²⁺ release from the ER. by Xiaowen Jiang (8291814)

Data_Sheet_1_Triadin Decrease Impairs the Expression of E-C Coupling Related Proteins in Muscles of MPTP-Induced Parkinson’s Disease Mice.PDF by Min Hyung Seo (10684422)

“…In this study, the expression levels of the components of RYR channels decreased in the quadriceps femoris muscle of MPTP-induced PD mice and in C2C12 cells treated with 1-methyl-4-phenylpyridinium. …”

Structural Studies of the <i>Methylosinus trichosporium</i> OB3b Soluble Methane Monooxygenase Hydroxylase and Regulatory Component Complex Reveal a Transient Substrate Tunnel by Jason C. Jones (9191264)

“…The kinetics of reaction of O₂ with the diferrous sMMOH:MMOB complex in solution show that use of the MMOB V41R variant decreases the rate constant for O₂ binding >25000-fold without altering the component affinity. …”

Structural Studies of the <i>Methylosinus trichosporium</i> OB3b Soluble Methane Monooxygenase Hydroxylase and Regulatory Component Complex Reveal a Transient Substrate Tunnel by Jason C. Jones (9191264)

“…The kinetics of reaction of O₂ with the diferrous sMMOH:MMOB complex in solution show that use of the MMOB V41R variant decreases the rate constant for O₂ binding >25000-fold without altering the component affinity. …”

Decrease in striatal DA release in D2-cKO mice without changes in DA reuptake kinetics or in striatal surface DAT levels. by Nicolas Giguère (7310270)

<i>Emx1</i>-cKO mice lack the neocortex. by Sathish Venkataramanappa (10331993)

Decreased fetal weight in CrryshRNA mice. by Manu Banadakoppa (9199271)

“…<p>Fetal and placental weights were measured at 17.5 dpc soon after euthanasia (n = 5–7), A) Average fetal weight was significantly reduced (<i>p</i> = 0.048) in CrryshRNA mice compared to control group B) Average placental weight was not different between the two groups C) Fetal-placental weight ratio was significantly decreased (<i>p</i> = 0.045) in Crry shRNA mice compared to control mice.…”

RcbA and RcbB co-operatively decrease motility independent of CaCl₂ concentration. by Shobnom Mustaree (21728815)

Silencing of <i>NbNBR1</i> decreases the accumulation of βC1. by Tingting Zhou (163678)

Effects of nuclear hormone treatments on <i>kcnk5b</i>, <i>rcan2</i>, and control genes in pectoral fin buds and adult fins and sufficiency/necessity experiments for <i>rcan2</i>. by Xiaowen Jiang (8291814)

<b>Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decrease ISR activation in DRG neurons</b> by Muhammad Saad Yousuf (20745168)

Total number of CHWs in scenario C when model parameters are increased or decreased by 10%. by Clara Champagne (5634644)

RV-C15 replicates in ciliated epithelial cells, leading to decreased CDHR3 levels. by Talita B. Gagliardi (6791720)

This is the raw data of Western blot in Met-5A cell. by Yangyang Yin (14323701)

Subjects:

Homozygous deletion of <i>ERG251</i> leads to the decreased ergosterol accumulation in the absence of FLC and decreased production of toxic dienol in the presence of FLC. by Xin Zhou (54275)

Subjects:

Inducible microRNA-200c decreases motility of breast cancer cells and reduces filamin A by Bojan Ljepoja (4921255)

<i>cel1Δ</i> shows decreased virulence in two different models of cryptococcosis. by Corinna Probst (1538371)

Activating cAMP synthesis decreases liberation of propionyl-CoA from cholesterol. by Kaley M. Wilburn (12060476)