Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity by Jinxin Che (791250)

Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity by Jinxin Che (791250)

Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity by Jinxin Che (791250)

Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity by Jinxin Che (791250)

Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity by Jinxin Che (791250)

siRNA treatment decreases ADAMTS-1 nuclear pattern in MDA-MB-231 cells. by Suély V. Silva (3233223)

“…Nuclear particle size is smaller with decreased ADAMTS-1 when compared to control. (C) Immunoblot shows the decrease of ADAMTS-1 at nuclear fraction and conditioned medium in cells treated by siRNA (boxed). …”

Expression of SPDEF in prostate adenocarcinoma cells decreased prostate carcinogenesis in orthotopic model. by Xin-Hua Cheng (154368)

“…<p>Mouse prostates were harvested 5 weeks after inoculation of control TRAMP C2 adenocarcinoma cells or TRAMP C2 cells with stable expression of SPDEF (SPDEF OE). …”

A brief course of RAP treatment decreases markers of proliferation and increases markers of differentiation. by Karin M. Hardiman (555189)

“…<p><i>CDX2P-CreER^T2 Apc^fl/fl</i> mice were injected with TAM and monitored until polyposis was seen endoscopically, then the mice were treated with vehicle or RAP at 3 mg/kg concentration for periods of one, three, or five days (N = 5 per timepoint). …”

Decreased 11ß-HSD1 protein level by IGF-I overexpression <i>in vivo</i> and a direct treatment with IGF-I. by Subrata Chowdhury (787208)

“…<p><b>A</b>. IGF-I overexpression decreased the levels of 11ß-HSD1 in pancreatic islets, liver and visceral fat, shown in Western blots. …”

Decreased health-related quality of life in angiodysplasia patients: A cross-sectional cohort by Karina V. Grooteman (4050388)

Hemodiafiltration Decreases Serum Levels of Inflammatory Mediators in Severe Leptospirosis: A Prospective Study by Sérgio Aparecido Cleto (3143949)

“…We previously demonstrated that early initiation of sustained low-efficiency dialysis (SLED) followed by daily SLED significantly decreases mortality. …”

Fig 5 - by Lixin Du (240090)

Subjects:

Oxytocin decreases postsynaptic CeA spontaneous GABAergic transmission and blocks presynaptic alcohol effects. by Brendan J. Tunstall (6593357)

“…^#Significant difference between groups (<i>p</i> < 0.05). Amp, amplitude; CeA, central nucleus of the amygdala; EtOH, ethanol; Freq, frequency; mIPSC, miniature inhibitory postsynaptic current; OT, oxytocin; OTA, desGly-NH2-d(CH2)5[D-Tyr2,Thr4]OVT; sIPSC, spontaneous inhibitory postsynaptic current; TTX, tetrodotoxin.…”

Water streamflow decreases in response to acid deposition in a subtropical forest watershed in China by Linhua Wang (16849212)

Proteasome activity was decreased in the <i>myc-rpt6-S119A</i> mutant. by Esther Magdalena Marquez-Lona (4183126)

“…RP = Regulatory Particle, CP = Core Particle. (C) The chymotrypsin-like activity of 26S proteasomes in whole cell lysates of stationary phase cells (A₆₀₀>5.0) was monitored by Suc-LLVY-AMC cleavage over time on microplate reader (ex. 360nm and em. 465nm). …”

Functional characterization of the V9D and R10C substitutions in chicken ARF. by Doreen Schwochow Thalmann (3912649)

“…(C) Assessment of the effect of the two coding mutations on the interaction between ARF and MDM2 based on a luciferase assay. …”

A Functional 12T-Insertion Polymorphism in the <i>ATP1A1</i> Promoter Confers Decreased Susceptibility to Hypertension in a Male Sardinian Population by Victoria L. Herrera (383897)

“…To test the effects of decreased α1Na,K-ATPase expression on blood pressure, we measured blood pressure by radiotelemetry in three month-old, highly inbred heterozygous knockout <i>ATP1A1+/−</i> male mice with resultant 58% reduction in ATP1A1 protein levels. …”

NCM exposure increases hepatic creatine kinase activity and total ATPase activity, which is associated with decreases in hepatic ABCA1, CD36, and L-FABP protein expression and circ... by Ryan J. Mailloux (50825)

Subjects: “…mitochondrial ATP synthase subunit ATP 5A…”

Propagation of an action potential through ephaptic coupling is achieved for a decreased extracellular conductivity. by Karoline Horgmo Jæger (6785450)

Aβ and 22C11 agonist decreased cholesterol uptake whereas the sAPP-derived peptide and SM-ϕ stimulated increased cholesterol uptake by Caco-2 cells. by Kendra L. Puig (334788)