Increasing temperature decreases oxygen concentration and decreasing oxygen content decreases neuronal excitability. by Yuguo Yu (172221)

“…Increasing temperature can dramatically decrease oxygen levels. B. Response of layer 2/3 pyramidal cells (n = 5) to the intracellular injection of a depolarizing current pulse (200 pA, 500 ms) at different temperatures (same experiments as in A). …”

Pravastatin decreases NSPC expansion <i>in vitro</i>. by Ross A. Carson (5184512)

The novel <i>carboxylesterase 1</i> variant c.662A>G may decrease the bioactivation of oseltamivir in humans by Jaeseong Oh (3947381)

“…A novel <i>CES1</i> c.662A>G single nucleotide polymorphism (SNP) was predicted to decrease CES1 enzymatic activity in an <i>in silico</i> analysis. …”

Decreased S100A9 expression alleviates Clostridium perfringens beta2 toxin-induced inflammatory injury in IPEC-J2 cells by Jie Li (13877648)

Pre-treatment of IOZCAS-Spex-II cells with CPT and HCPT decreased Topo1 specific activity in a time-dependent manner. by Lan Zhang (90951)

Pre-treatment of IOZCAS-Spex-II cells with CPT and HCPT decreased Topo1 specific activity in a dose-dependent manner. by Lan Zhang (90951)

A decrease in circulating CXCR5+CD4+ Tfh cells is associated with HCC progression, and CXCR5+CD4+ Tfh cells are decreased in tumor regions. by Yiqiong Jia (692871)

“…<p>(A) The prevalence of CXCR5+CD4+ Tfh cells decreases with progressive stages in HCC. …”

Decreased <i>Pax2</i> expression in <i>p53^−/−</i> embryonic kidneys. by Zubaida Saifudeen (135684)

“…<b>B</b>) In situ hybridization. Decreased expression of <i>Pax2</i> mRNA at E12.5. …”

Downregulation of LGR4 decreases ARPE-19 cell migration. by Qiang Hou (495704)

mTOR inhibition with rapamycin decreases MEC survival and branching. by Meghan M. Morrison (683792)

Shoot-to-root translocation of GmNN1/FT2a regulates soybean nodulation. by Xinxin Li (281237)

Annexin A2 accumulates in the nucleus and decreases in the cytoplasm in response to genotoxic agents. by Patricia A. Madureira (114480)

The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits - Fig 4 by Jin Zhou (90734)

PDGF-BB maintains Bcl2/Bax ratio and decreases caspase-3 activation induced by Tat and morphine. by Shaily Malik (226661)

“…(B) Densitometric analysis of the blots shown in (A). Tat and morphine together resulted in a significantly decreased ratio of Bcl2/Bax, indicating cell's progress towards apoptosis. …”

Antibody response elicited by SARS-CoV-2 vaccines. by Chris Davis (647632)

A New Rotane Family:  Synthesis, Structure, Conformation, and Dynamics of [3.4]-, [4.4]-, [5.4]-, and [6.4]Rotane¹ by Lutz Fitjer (2466634)

“…All syntheses are based on bicyclobutylidene (<b>9</b>):  [2+1] cycloaddition of cyclobutylidene yields [3.4]rotane (<b>5</b>) (<b>9</b>−<b>5</b>), [2+2] cycloaddition of trimethyleneketene followed by spiroalkylation of the resulting trispiroketone <b>10</b> yields [4.4]rotane (<b>6</b>) (<b>9</b>−<b>10</b>−<b>13</b>−<b>14</b>−<b>6</b>), homologization of <b>10</b> via β-hydroxy selenides gives access to tetraspiroketone <b>11</b> and pentaspiroketone <b>12</b> (<b>10</b>−<b>15</b>−<b>11</b>−<b>16</b>−<b>12</b>), and further elaboration directed toward a cyclopropylcarbene−cyclobutene rearrangement yields [5.4]rotane (<b>7</b>) and [6.4]rotane (<b>8</b>) [<b>11</b>(<b>12</b>)−<b>18</b>(<b>24</b>)−<b>19</b>(<b>25</b>)−<b>20</b>(<b>26</b>)−<b>21</b>(<b>27</b>)−<b>22</b>(<b>28</b>)−<b>23</b>(<b>29</b>)−<b>7</b>(<b>8</b>)]. …”

<i>Ex vivo</i> deletion of <i>sirt1</i> decreases expression of RUNX2 downstream targets. by Kayvan Zainabadi (502381)

“…<b>C)</b> While SIRT1 knockout osteoblasts (Cre) express comparable amounts of Runx2, they show a near two-fold reduction in the expression of the Runx2 downstream target, <u>Osterix</u> (Osx). …”

Impact of individual GLP-1 receptor agonists on hypoglycemia, treatment discontinuation, HbA1c <7.0%, HbA1c <6.5% of direct pairwise meta-analysis. by Zhixia Li (2736331)

Subjects:

Inhibition of PKC or Rho protein kinase decreases Ad5 wild type replication <i>in vitro</i>. by Alice Liu (4814415)

a-c: Proximal tibia (PT) EPO receptor (EPO-R) decreases in uremic rats, as shown by Western blot (Fig. 5a) and immunohistochemistry (Fig. 5b). by Daniel Landau (440830)

“…Animals received a single bolus of IV rhEPO (25 U/kg) or saline, 5 minutes prior to sacrifice. …”