Clinical molecular testing for <i>ASXL1</i> c.1934dupG p.Gly646fs mutation in hematologic neoplasms in the NGS era - Fig 2 by Santiago Montes-Moreno (135753)

“…As shown in the figure, there is a shift in the clonal composition of the disease with a decrease in the three <i>IDH1</i> mutations first identified (<i>IDH1</i> c603_606del p.S202fs*7, <i>IDH1</i> c624T>G p.Y208* and <i>IDH1</i> c611G>A p.G204D) after therapy, but the emergence of new clones characterized by <i>FLT3</i> c.1471G>C p.V491L, <i>NPM1</i> c393_395dupGGA p. …”

Image5_c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease.TIF by Tamara Marín (12259079)

“…Our data demonstrate that: 1) c-Abl is activated in-vitro as well as in-vivo NPA models; 2) imatinib, a clinical c-Abl inhibitor, reduces autophagy-lysosomal pathway alterations, restores autophagy flux, and lowers sphingomyelin accumulation in NPA patient fibroblasts and NPA neuronal models and 3) chronic treatment with nilotinib and neurotinib, two c-Abl inhibitors with differences in blood-brain barrier penetrance and target binding mode, show further benefits. …”

Image5_c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease.TIF by Tamara Marín (12259079)

“…Our data demonstrate that: 1) c-Abl is activated in-vitro as well as in-vivo NPA models; 2) imatinib, a clinical c-Abl inhibitor, reduces autophagy-lysosomal pathway alterations, restores autophagy flux, and lowers sphingomyelin accumulation in NPA patient fibroblasts and NPA neuronal models and 3) chronic treatment with nilotinib and neurotinib, two c-Abl inhibitors with differences in blood-brain barrier penetrance and target binding mode, show further benefits. …”

Prolonged UCB exposure decreases the protein levels of NMDA NR1, NR2A and NR2B subunits in rat organotypic slice cultures. by Fang-Yu Chang (263325)

“…<p>(A) Representative immunoblots showing 10 µM UCB treatment for 48 h decreases NR1, NR2A and NR2B subunit expression in the hippocampal CA1 homogenate fractions. …”

Table2_CLPP inhibition triggers apoptosis in human ovarian granulosa cells via COX5A abnormality–Mediated mitochondrial dysfunction.XLSX by Xiong Yuan (4686325)

“…Functional experiments revealed that the inhibition of CLPP decreased the content and activity of oxidative respiratory chain complex IV by affecting the degradation of aggregated or misfolded COX5A, leading to the accumulation of reactive oxygen species and reduction of mitochondrial membrane potential, ultimately activating the intrinsic apoptotic pathways. …”

Persistence of aerosolized Phi6 in air. by Eloise Parry-Nweye (7548998)

Samples of the ROIs. by Qiang Huang (43791)

Drive dynamics for split^<50cM <i>ClvR</i>s with different genetic linkage and migration rates. by Georg Oberhofer (3401438)

Light microscopy views of cross-sections of the three species. by Giovanna Battipaglia (711570)

Cumulative average basal area for the three species. by Giovanna Battipaglia (711570)

Split <i>ClvR</i> and Inversions. by Georg Oberhofer (3401438)

Influence of Air Pollution Exposure on the microRNA Content of Neuronal Extracellular Vesicles in Subjects Affected by Major Depressive Disorder by Paola Monti (218762)

“…The regulatory function of NdEV miRNAs was investigated by gene target and pathway analysis. As a result, exposure to NO₂ was associated with decreased levels of miR-191 and miR-24, while PM_2.5 was negatively associated with miR-191, miR-223, miR-24, miR-320, miR-451, miR-572, and miR-638. …”

Basal area and CO₂ concentration data of the three species. by Giovanna Battipaglia (711570)

Data_Sheet_1_Platelet Phenotype Analysis of COVID-19 Patients Reveals Progressive Changes in the Activation of Integrin αIIbβ3, F13A1, the SARS-CoV-2 Target EIF4A1 and Annexin A5.d... by Huriye Ercan (11679229)

“…Depending on COVID-19 disease status and mortality, increased amounts of annexin A5 (ANXA5), eukaryotic initiation factor 4A-I (EIF4A1), and transaldolase (TALDO1) were found in the platelet proteome and also correlated with the nasopharyngeal viral load. …”

Persistence of Phi6 on materials. by Eloise Parry-Nweye (7548998)

Alterations of Ceramides, Acylcarnitines, GlyceroLPLs, and Amines in NSCLC Tissues by Jie Zhang (64655)

Subjects:

Cabozantinib treatment decreased microvessel density, but not proliferation and increased hypoxic stress in LuCaP 93 and LuCaP 173.1 patient-derived xenografts. by Mark P. Labrecque (10011469)

Effects of chronic PG-LPS infusion on fibrosis in cardiac muscle. by Kenichi Kiyomoto (12709675)

Histograms of caloric intake <i>C</i>_in (food), caloric output <i>C</i>_out (activity), and caloric ratio <i>C</i>_rat for the states of the contiguo... by Sharon E. Alajajian (3624806)

Experimental procedure and consumption of food and water during chronic PG-LPS infusion in mice. by Kenichi Kiyomoto (12709675)