Model of regulation of cellulase expression by ClrB, CreA, AmyR, XlnR and ClrB-2 in <i>P</i>. <i>oxalicum</i>. by Zhonghai Li (460152)

“…Lack of the major intracellular beta-glucosidase Bgl2 facilitates the accumulation of intracellular cellodextrins, which can trigger signaling cascades that include expression of cellulase genes repressed by CreA and AmyR and activated by ClrB, XlnR and ClrB-2. …”

Image_2_P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3*Leiden Mice via Systemic Inhibition of Regulatory T Cells.JPEG by Alwin de Jong (4012250)

“…Expression of FoxP3 by systemic CD4⁺ T cells decreased 1.8 fold in ApoE3^*LeidenxPCAF^−/− after 5 months HFD and remained significantly reduced after 5 months of HFD. …”

Data_Sheet_1_Effect of Pilates on Glucose and Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.docx by Zehua Chen (12054)

“…Overall, the Pilates group (PG) had a significantly greater reduction in post-prandial blood glucose than the control group (CG) (MD = −22.25 mg/dL, 95% CI: [−28.34, 16.17] mg/dL, P < 0.00001, I² = 0%); glycated hemoglobin (HbA1c) (MD = −0.78%, 95% CI: [−1.13, −0.42]%, P < 0.0001, I² = 88%); total cholesterol (TC) (MD = −20.90 mg/dL, 95% CI: [−37.21, −4.60] mg/dL, P = 0.01, I² = 84%); triglycerides (TG) (MD = −12.59 mg/dL, 95% CI: [−19.88, −5.29] mg/dL, P = 0.0007, I² = 86%); and low density lipoprotein cholesterol (LDL-C) (MD = −12.39 mg/dL, 95% CI: [−16.82, −7.95] mg/dL, P < 0.00001, I² = 45%) compared to CG, whereas no significant difference was detected between the two groups in fasting blood glucose (MD = −7.04 mg/dL, 95% CI: [−17.26, 3.17] mg/dL, P = 0.18, I² = 93%), insulin (MD = −1.44 μU/mL, 95% CI: [−4.30, 1.41] μU/mL, P = 0.32, I² = 0%); and high density lipoprotein cholesterol (HDL-C) (MD = −2.68 mg/dL, 95% CI: [−9.03, 3.67] mg/dL, P = 0.41, I² = 89%). …”

Data_Sheet_1_Effect of Pilates on Glucose and Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.docx by Zehua Chen (12054)

“…Overall, the Pilates group (PG) had a significantly greater reduction in post-prandial blood glucose than the control group (CG) (MD = −22.25 mg/dL, 95% CI: [−28.34, 16.17] mg/dL, P < 0.00001, I² = 0%); glycated hemoglobin (HbA1c) (MD = −0.78%, 95% CI: [−1.13, −0.42]%, P < 0.0001, I² = 88%); total cholesterol (TC) (MD = −20.90 mg/dL, 95% CI: [−37.21, −4.60] mg/dL, P = 0.01, I² = 84%); triglycerides (TG) (MD = −12.59 mg/dL, 95% CI: [−19.88, −5.29] mg/dL, P = 0.0007, I² = 86%); and low density lipoprotein cholesterol (LDL-C) (MD = −12.39 mg/dL, 95% CI: [−16.82, −7.95] mg/dL, P < 0.00001, I² = 45%) compared to CG, whereas no significant difference was detected between the two groups in fasting blood glucose (MD = −7.04 mg/dL, 95% CI: [−17.26, 3.17] mg/dL, P = 0.18, I² = 93%), insulin (MD = −1.44 μU/mL, 95% CI: [−4.30, 1.41] μU/mL, P = 0.32, I² = 0%); and high density lipoprotein cholesterol (HDL-C) (MD = −2.68 mg/dL, 95% CI: [−9.03, 3.67] mg/dL, P = 0.41, I² = 89%). …”

DataSheet_2_Causality of genetically proxied immunophenotypes on cardiovascular diseases: a Mendelian randomization study.docx by Xuehan Wang (10590882)

“…Increased levels of IgD- CD38dim absolute count were associated with a higher susceptibility to AF, while increased expression of CD14+ CD16+ monocytes, CD62L on CD62L+ myeloid dendritic cells, and CD16 on CD14- CD16+ monocytes were linked to a decreased susceptibility to AF. …”

DataSheet_1_Causality of genetically proxied immunophenotypes on cardiovascular diseases: a Mendelian randomization study.xlsx by Xuehan Wang (10590882)

“…Increased levels of IgD- CD38dim absolute count were associated with a higher susceptibility to AF, while increased expression of CD14+ CD16+ monocytes, CD62L on CD62L+ myeloid dendritic cells, and CD16 on CD14- CD16+ monocytes were linked to a decreased susceptibility to AF. …”

Supplementary Material for: Characterisation of an ischaemia-reperfusion model for the formation of a stage II pressure injury in diabetic mice by figshare admin karger (2628495)

“…On day 10, db/db mice exhibited delayed wound closure, as well as impaired regeneration of the panniculus carnosus and dermis, with significantly decreased mRNA levels of VEGF and HSP90. Conclusion: Ischaemia lasting 4 h is the appropriate duration for generating stage II pressure injuries in diabetic mice, which may be applicable to generate a reproducible model of stage II pressure injury caused by ischaemia-reperfusion injury. …”

Table_1_Omeprazole Minimally Alters the Fecal Microbial Community in Six Cats: A Pilot Study.PDF by Sarah M. Schmid (5103848)

“…Therefore, the purpose of this pilot study was to evaluate the effect of prolonged omeprazole administration on the fecal microbiome and metabolome in healthy cats to identify targets for analysis in a larger subset of cats with GI disease. A within-subjects, before and after, pilot study was performed whereby six healthy adult cats received 60 days of placebo (250 mg lactose PO q 12 h) followed by 5 mg (0.83–1.6 mg/kg PO q 12 h) omeprazole. …”

DataSheet1_Effects of astaxanthin on microRNA expression in a rat cardiomyocyte anoxia-reoxygenation model.PDF by Xinxin Zhang (309944)

“…High-throughput sequencing and qPCR showed that microRNAs rno-miR-125b-5p and rno-let-7c-1-3p were differentially expressed (|log2| ≥ 0.585, q < 0.1) between the normal, anoxia-reoxygenation, and astaxanthin (1.25 μM) groups. …”

Analyzing the effect of <i>ATOX1</i> and <i>TP53</i> gene siRNA-mediated knockdown on mutual expression, A549 cell line. by Sergey Tsymbal (17691776)

Difference in NuA4 and resection signal seen between wild type and mutants not caused by uneven HO cutting at <i>MAT</i> locus and a different method to measure DNA end resection i... by Salar Ahmad (11457776)

“…<p>(A-C) HO cutting efficiency at MAT locus in G1 synchronized cells after 3 hours of galactose induction between wild type and, <i>xrs2</i>Δ<i>rad9</i>Δ (A), <i>xrs2</i>Δ<i>rad9</i>Δy<i>ku80</i>Δ (B), <i>mre11-H125N</i> (C). …”

Supplementary Material for: Risk Factors Assessed in Adolescence and the Later Risk of Stroke in Men: A 33-Year Follow-Up Study by Högström G. (3683686)

Table_1_Use of a Smartphone Application to Speed Up Interhospital Transfer of Acute Ischemic Stroke Patients for Thrombectomy.DOCX by Sheng-Ta Tsai (255653)

“…The total number of transfer patients increased over the years: 63, 113, 175, respectively. The mean door-to-puncture time decreased significantly, going from 109, through 102, to 92 min. …”

Impact of Ten-Valent Pneumococcal Conjugate Vaccination on Invasive Pneumococcal Disease in Finnish Children – A Population-Based Study by Jukka Jokinen (328057)

“…<div><p>Background</p><p>The ten-valent pneumococcal conjugate vaccine (PCV10) was introduced into the Finnish National Vaccination Program (NVP) in September 2010 with a 2+1 schedule (3, 5, 12 months) without catch-up vaccinations. …”

Public Acceptability in the UK and USA of Nudging to Reduce Obesity: The Example of Reducing Sugar-Sweetened Beverages Consumption by Dragos C. Petrescu (2824934)

“…Participants (n = 1093 UK and n = 1082 USA) received a description of each of the five interventions which varied, by randomisation, in how the interventions were said to affect behaviour: (a) via conscious processes; (b) via non-conscious processes; or (c) no process stated. …”

Image2_The Efficacy and Safety of Brolucizumab for the Treatment of nAMD: A Systematic Review and Meta-Analysis.JPEG by Junlan Chuan (6648617)

“…Changes in best corrected visual acuity (BCVA) and central sub-field thickness (CSFT) and incidence of adverse events, serious adverse events, and serious ocular adverse events were extracted from eligible RCTs. A meta-analysis was performed using RevMan 5.4.1.…”

The Role of Histone Methylation and H2A.Z Occupancy during Rapid Activation of Ethylene Responsive Genes by Yongfeng Hu (187019)

“…After induction, H3K4me3 was increased in the 5′ region and the gene body of <em>ERF1</em>, while H3K27me3 was decreased in the promoter of <em>AtERF14</em>. …”

Image1_The Efficacy and Safety of Brolucizumab for the Treatment of nAMD: A Systematic Review and Meta-Analysis.JPEG by Junlan Chuan (6648617)

“…Changes in best corrected visual acuity (BCVA) and central sub-field thickness (CSFT) and incidence of adverse events, serious adverse events, and serious ocular adverse events were extracted from eligible RCTs. A meta-analysis was performed using RevMan 5.4.1.…”

Table_1_Neurobiological outcomes of cognitive behavioral therapy for obsessive-compulsive disorder: A systematic review.docx by Andrea Poli (3623465)

“…Nevertheless, further studies are necessary to frame the OCD spectrum in a dimensional way.</p>…”

Supplementary Material for: How the COVID-19 Pandemic Impacted Neurological Hospital Admissions in Germany - A Retrospective Analysis by figshare admin karger (2628495)

“…The COVID-19 pandemic has had a major impact on health care. Shifts in inpatient and outpatient case numbers and morbidity have been quantified in other medical specialties (e.g., oncology and psychiatry). …”