Video_2_A Link Between Methylglyoxal and Heart Failure During HIV-1 Infection.WMV by Prasanta K. Dash (5258294)

“…Histopathological and biochemical analyses of cardiac tissues from Hu-mice 17 weeks post-infection affirmed MG increase with a concomitant decrease in expression of the MG-degrading enzyme glyoxalase-1 (Glo1). …”

Video_1_A Link Between Methylglyoxal and Heart Failure During HIV-1 Infection.WMV by Prasanta K. Dash (5258294)

“…Histopathological and biochemical analyses of cardiac tissues from Hu-mice 17 weeks post-infection affirmed MG increase with a concomitant decrease in expression of the MG-degrading enzyme glyoxalase-1 (Glo1). …”

Video_3_A Link Between Methylglyoxal and Heart Failure During HIV-1 Infection.WMV by Prasanta K. Dash (5258294)

“…Histopathological and biochemical analyses of cardiac tissues from Hu-mice 17 weeks post-infection affirmed MG increase with a concomitant decrease in expression of the MG-degrading enzyme glyoxalase-1 (Glo1). …”

Video_4_A Link Between Methylglyoxal and Heart Failure During HIV-1 Infection.WMV by Prasanta K. Dash (5258294)

“…Histopathological and biochemical analyses of cardiac tissues from Hu-mice 17 weeks post-infection affirmed MG increase with a concomitant decrease in expression of the MG-degrading enzyme glyoxalase-1 (Glo1). …”

Table_2_Older Compared With Younger Adults Performed 467 Fewer Sit-to-Stand Trials, Accompanied by Small Changes in Muscle Activation and Voluntary Force.DOCX by Paulo Cezar Rocha dos Santos (5021435)

“…</p><p>Methods: Healthy older (n = 12) and younger (n = 11) adults performed rSTS, at a controlled frequency dictated by a metronome (2 s for cycle), to failure or for 30 min. …”

Table_2_Older Compared With Younger Adults Performed 467 Fewer Sit-to-Stand Trials, Accompanied by Small Changes in Muscle Activation and Voluntary Force.DOCX by Paulo Cezar Rocha dos Santos (5021435)

“…</p><p>Methods: Healthy older (n = 12) and younger (n = 11) adults performed rSTS, at a controlled frequency dictated by a metronome (2 s for cycle), to failure or for 30 min. …”

Effect of extended-release buprenorphine (1 mg/kg SC) as compared to saline control on tactile hypersensitivity in a model of inflammatory hypersensitivity in rats. by Christina M. Larson (18196213)

Computational modeling framework and comparison against biological data. by Joonas P. Kosonen (14509643)

“…(A) Unconfined compression (15% axial strain, 1 Hz loading frequency) of injured cartilage was simulated to obtain maximum shear strain distributions. Two biomechanically-induced degradation mechanisms were triggered locally in regions experiencing abnormal maximum shear strains; chondrocyte necrosis (mechanism I) and chondrocyte damage-associated overproduction of reactive oxygen species (ROS) followed by cell apoptosis (mechanism II). …”

Image_2_Algal Oil Rich in n-3 PUFA Alleviates DSS-Induced Colitis via Regulation of Gut Microbiota and Restoration of Intestinal Barrier.TIF by Zhenxia Xu (9774668)

“…This study aimed to investigate the effects of DHA algal oil on colonic inflammation and intestinal microbiota in dextran sulfate sodium (DSS)-induced colitis mice model. Male C57BL/6 mice was induced colitis by 2.5% DSS and followed by 2 weeks of treatment with algal oil (250 or 500 mg/kg/day). …”

Dynamine 3 as a diagnostic and prognostic biomarker in pancreatic cancer: Implications for early detection and targeted therapy by Fatih Yay (20606054)

“…</p> <p>For differential gene expression analysis, TCGA TARGET GTEx study on the UCSC Xena and GEO datasets were utilized; for the analysis of changes in gene expression according to clinical and pathological characteristics, UALCAN was employed; for Overall Survival (OS) analysis, Kaplan-Meier Plotter was used; for gene alteration analysis, cBioPortal was utilized; for immune cell infiltration analysis, Tumor Immune Estimation Resource (TIMER) and TIMER2.0 were employed; for enrichment analyses Enrichr was used; for Gene Set Correlation Enrichment Analysis Gscore was used on GSE15471; for essentiality of DNM3 gene in pancratic cancer cell lines DepMap was used; and for the detection of miRNAs, miRDB was utilized; ENCORI was used for gene-miRNA correlation and miRNA prognosis analyses.…”

Supplementary Material for: A Rational Use of Clozapine Based on Adverse Drug Reactions, Pharmacokinetics, and Clinical Pharmacopsychology by deLeon J. (6235214)

Fig 11 - by Maike Stegen (8578665)

“…One representative blot of n = 2. This figure is cropped. Full-length blots are represented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0247087#pone.0247087.s003" target="_blank">S3C and S3D Fig</a>. …”

Table 1_Identification of deleterious variants associated with male infertility genes in a cohort of idiopathic hypospermatogenesis patients.xlsx by Nisha Sharma (598539)

“…</p>Results<p>Genomic analysis of SNVs identified rare deleterious candidate variants in CFTR (c.1265C>T; p.Ser422Phe), CYP21A2 (c.955C>T; p.Gln319Glu), SRD5A2 (c.737G>A; p.Arg245Gln), LHCGR (c.378A>C; p.Lys126Asn) and AR (c.2179C>A; p.Arg727Ser) genes associated with 7/42 idiopathic hypospermatogenesis patients. …”

Image4_PKA inhibition is a central step in D,L-methadone-induced ER Ca2+ release and subsequent apoptosis in acute lymphoblastic leukemia.JPEG by Hamza Kamran (18433152)

“…This is consistent with the decrease in PKA-dependent (i) inhibitory PLCβ3 Ser1105 phosphorylation that leads to PLCβ3 activation and ER Ca²⁺ release, and (ii) BAD Ser118 phosphorylation, which together ultimately result in caspase activation and apoptosis. …”

Image7_PKA inhibition is a central step in D,L-methadone-induced ER Ca2+ release and subsequent apoptosis in acute lymphoblastic leukemia.JPEG by Hamza Kamran (18433152)

“…This is consistent with the decrease in PKA-dependent (i) inhibitory PLCβ3 Ser1105 phosphorylation that leads to PLCβ3 activation and ER Ca²⁺ release, and (ii) BAD Ser118 phosphorylation, which together ultimately result in caspase activation and apoptosis. …”

Image6_PKA inhibition is a central step in D,L-methadone-induced ER Ca2+ release and subsequent apoptosis in acute lymphoblastic leukemia.JPEG by Hamza Kamran (18433152)

“…This is consistent with the decrease in PKA-dependent (i) inhibitory PLCβ3 Ser1105 phosphorylation that leads to PLCβ3 activation and ER Ca²⁺ release, and (ii) BAD Ser118 phosphorylation, which together ultimately result in caspase activation and apoptosis. …”

Image1_PKA inhibition is a central step in D,L-methadone-induced ER Ca2+ release and subsequent apoptosis in acute lymphoblastic leukemia.JPEG by Hamza Kamran (18433152)

“…This is consistent with the decrease in PKA-dependent (i) inhibitory PLCβ3 Ser1105 phosphorylation that leads to PLCβ3 activation and ER Ca²⁺ release, and (ii) BAD Ser118 phosphorylation, which together ultimately result in caspase activation and apoptosis. …”

Image3_PKA inhibition is a central step in D,L-methadone-induced ER Ca2+ release and subsequent apoptosis in acute lymphoblastic leukemia.JPEG by Hamza Kamran (18433152)

“…This is consistent with the decrease in PKA-dependent (i) inhibitory PLCβ3 Ser1105 phosphorylation that leads to PLCβ3 activation and ER Ca²⁺ release, and (ii) BAD Ser118 phosphorylation, which together ultimately result in caspase activation and apoptosis. …”

The contribution of tax expenditure in fiscal consolidation in post-crisis economies: a case study of the context in Portugal by João Ricardo Catarino (12853650)

Table_1_Deriving a Proxy for Iron Limitation From Chlorophyll Fluorescence on Buoyancy Gliders.DOCX by Thomas J. Ryan-Keogh (8799179)

“…Diel fluctuations in chlorophyll fluorescence are affected by both photosynthetic efficiency and non-photochemical quenching (NPQ), where NPQ is a decrease in fluorescence through the dissipation of excess energy as heat. …”