Image_3_Social Deficits and Cerebellar Degeneration in Purkinje Cell Scn8a Knockout Mice.JPEG by Xiaofan Yang (767342)

“…By 5 months of age, Scn8a^flox/flox, L7Cre⁺ mice began to exhibit cerebellar Purkinje cell loss and reduced molecular thickness. …”

Table_1_Social Deficits and Cerebellar Degeneration in Purkinje Cell Scn8a Knockout Mice.XLSX by Xiaofan Yang (767342)

“…By 5 months of age, Scn8a^flox/flox, L7Cre⁺ mice began to exhibit cerebellar Purkinje cell loss and reduced molecular thickness. …”

Image_1_Social Deficits and Cerebellar Degeneration in Purkinje Cell Scn8a Knockout Mice.JPEG by Xiaofan Yang (767342)

“…By 5 months of age, Scn8a^flox/flox, L7Cre⁺ mice began to exhibit cerebellar Purkinje cell loss and reduced molecular thickness. …”

Image_4_Social Deficits and Cerebellar Degeneration in Purkinje Cell Scn8a Knockout Mice.JPEG by Xiaofan Yang (767342)

“…By 5 months of age, Scn8a^flox/flox, L7Cre⁺ mice began to exhibit cerebellar Purkinje cell loss and reduced molecular thickness. …”

Image_5_Novel prognostic features and personalized treatment strategies for mitochondria-related genes in glioma patients.jpeg by Ji Wu (217440)

“…</p>Results<p>COX assembly mitochondrial protein homolog (CMC1), Cytochrome c oxidase protein 20 homolog (COX20) and Cytochrome b-c1 complex subunit 7 (UQCRB) were identified as prognostic key genes in glioma, with UQCRB, CMC1 progressively increasing and COX20 progressively decreasing with decreasing risk scores. …”

Engineered deletions of 1-TbAd biosynthesis genes reveal gene functions and greatly expand the lipid signature. by Jacob A. Mayfield (19762468)

“…(B) Area-under-the-curve of extracted ion chromatograms tested 1-TbAd production by the parental Mtb strain (H37Rv) and single or two-gene knockouts as well as the <i>Rv3378c</i> deletion complemented with <i>Rv3378c</i>. …”

<i>Klf5</i> overexpression in intestinal epithelia increases STAT3 phosphorylation <i>in vivo</i>. by Marie-Pier Tetreault (320873)

“…(<b>C</b>) Western blot of colonic epithelial scrapings from control (Cn) and <i>Villin-Klf5</i> (Vl) mice at the indicated time points following DSS treatment revealed increased phospho-STAT3 and phospho-JAK2 in <i>Villin-Klf5</i> mice at day 7, while phospho-STAT3 was decreased in <i>Villin-Klf5</i> mice at day 0 and unchanged at day 3. …”

Responses of Herbivorous Fishes and Benthos to 6 Years of Protection at the Kahekili Herbivore Fisheries Management Area, Maui - Fig 5 by Ivor D. Williams (331075)

Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System by Alain Le Coupanec (421447)

“…We identified one predominant mutation at amino acid 758 (from RRSR↓ <u><b>G</b></u>₇₅₈ to RRSR↓<u><b>R</b></u>₇₅₈), which introduces a putative furin-like cleavage (↓) site. Using a molecular cDNA infectious clone to generate a corresponding recombinant virus, we show for the first time that such point mutation in the HCoV-OC43 S glycoprotein creates a functional cleavage site between the S1 and S2 portions of the S protein. …”

Homovanillic acid and 5-hydroxyindole acetic acid as biomarkers for dementia with Lewy bodies and coincident Alzheimer’s disease: An autopsy-confirmed study by Satoru Morimoto (3720502)

“…We examined levels of homovanillic acid (HVA), 5-hydroxyindole acetic acid (5-HIAA), tau, phosphorylated tau (p-tau), and beta-amyloid (Aβ) 1–42 in cerebrospinal fluid (CSF) to evaluate their viability as biomarkers to discriminate among different forms of dementia. …”

Table_2_New evidence for the effect of type 2 diabetes and glycemic traits on testosterone levels: a two-sample Mendelian randomization study.xlsx by Chengyang Jiang (1540369)

“…Each unit (%) increase in HbA1c was associated with 0.060nmol/L decrease in sex hormone-binding globulin (95%CI: -0.113, -0.007, p= 0.026). …”

After 8 weeks of treatment, body fat analysis and bone mineral density testing of mice in each group. by Xueqin lu (22250795)

Levels of degron-tagged AIR-2 and kinase-dead AIR-2 transgenes in worm strains. by Nikita S. Divekar (5714540)

“…Comparison of the endogenously-expressed bands shows a decrease upon auxin addition, though it is worth noting that these samples were generated from whole worms, while AIR-2 was only depleted in the germ line. …”

Data_Sheet_1_Functional Change of Effector Tumor-Infiltrating CCR5+CD38+HLA-DR+CD8+ T Cells in Glioma Microenvironment.docx by Pin-Yuan Chen (391703)

“…In this study, we examined the level of CD8⁺ T-cell activation in a group of 143 patients with glioma and determined that peripheral CD3⁺ T cells decreased in accordance with disease severity. …”

Fig 3 - by Changhyun Lim (8693979)

The trends of cholesterol metabolism-related gene expression in liver tissue. by Xueqin lu (22250795)

Beyond Pressure Gradients: The Effects of Intervention on Heart Power in Aortic Coarctation by Joao Filipe Fernandes (3636982)

“…No significant changes in IHP, EHP or power efficiency were observed in patients initially presenting with IHP < 5W.</p><p>Conclusion</p><p>It was demonstrated that interventional treatment of coarctation resulted in a decrease in IHP. …”

ISP2 and ISP3 define two additional novel sub-compartments of the IMC. by Josh R. Beck (242399)

“…<p><b>A.</b> BLAST analysis within the <i>T. gondii</i> genome identified two paralogs of ISP1 we denoted ISP2 and ISP3. …”

DataSheet1_RETRACTED: MiRNA-200b Regulates RMP7-Induced Increases in Blood-Tumor Barrier Permeability by Targeting RhoA and ROCKII.XLS by Teng Ma (109475)

“…Overexpression of miR-200b was also associated with a down-regulation in RhoA and ROCKII expression, concomitant with a decrease in BTB permeability. …”

Data_Sheet_5_Discovery of Novel Markers for Identifying Cognitive Decline Using Neuron-Derived Exosomes.CSV by Jiacheng Zhong (10433687)

“…By using a Tandem Mass Tag-based quantitative proteomic approach, we identified a total of 360 neuron-derived exosomal proteins. Subsequent fuzzy c-means clustering revealed two clusters of proteins displaying trends of gradually increasing/decreasing expression over the period of AD progression (normal to MCI to AD), both of which were mainly involved in immune response-associated pathways, proteins within these clusters were defined as bridge proteins. …”