Supplementary Material for: A case report of adult lead-poisoning followed by use of non-prescription Ayurvedic medication in Germany by figshare admin karger (2628495)

Synthesis of a chitosan nanoparticle suspension and its protective effects against enamel demineralization after an in vitro cariogenic challenge by Taís Chaves MAGALHÃES (12681551)

“…Results TEM images showed small spherical particles with diameter and zeta potential values of 79.3 nm and +47.9 mV, respectively. After the challenge, all groups showed an increase in Ra and a decrease in KHN values. …”

DataSheet_1_Adenosine receptors differentially mediate enteric glial cell death induced by Clostridioides difficile Toxins A and B.docx by Deiziane V. S. Costa (2627053)

“…Inhibition of protein kinase A (PKA) and CREB, both involved in the main signaling pathway driven by activation of adenosine receptors, decreased EGC apoptosis induced by both toxins. A2A agonist and A2B antagonist decreased S100B upregulation induced by C. difficile toxins in EGCs. …”

Replication data for: Long-term capture and handling effects on body condition, reproduction and survival in a semi-aquatic mammal by Rasmus Mohr Mortensen (9512723)

Clinical efficacy funnel chart. by Xiaoqi Wu (9503481)

“…Meta analysis results showed that, compared with conventional western medicine alone, STS combined with conventional western medicine could reduce the frequency (SMD = -2.61, 95%CI[-4.27, -0.96], <i>P</i> = 0.002) and duration (SMD = -4.01, 95%CI[-6.18, -1.84], <i>P</i> = 0.0003) of angina pectoris, improve ECG efficacy (OR = 3.61, 95%CI[2.79, 4.68], <i>P<</i>0.00001) and clinical symptom efficacy (OR = 4.02, 95%CI[3.32, 4.87], <i>P<</i>0.00001), reduce TG(SMD = -0.60, 95%CI[-1.04, -0.16], <i>P</i> = 0.008), TC(SMD = -3.86, 95%CI[-6.37, -1.34], <i>P</i> = 0.003), and LDL-C(SMD = -1.54, 95%CI[-2.67, -0.42], <i>P</i> = 0.007), decrease plasma viscosity(SMD = -1.02, 95%CI[-1.58, -0.47], <i>P<</i>0.0003), whole blood low shear viscosity(SMD = -0.85, 95%CI[-1.21, -0.49], <i>P<</i>0.00001), whole blood high shear viscosity(SMD = -0.82, 95%CI[-1.44, -0.20], <i>P</i> = 0.009), and erythrocyte aggregation index(SMD = -1.00, 95%CI[-1.75, -0.25], <i>P</i> = 0.009), and bring down CRP(SMD = -1.39, 95%CI[-1.91, -0.86], <i>P</i><0.00001). …”

Meta-analysis of blood rheology. by Xiaoqi Wu (9503481)

“…Meta analysis results showed that, compared with conventional western medicine alone, STS combined with conventional western medicine could reduce the frequency (SMD = -2.61, 95%CI[-4.27, -0.96], <i>P</i> = 0.002) and duration (SMD = -4.01, 95%CI[-6.18, -1.84], <i>P</i> = 0.0003) of angina pectoris, improve ECG efficacy (OR = 3.61, 95%CI[2.79, 4.68], <i>P<</i>0.00001) and clinical symptom efficacy (OR = 4.02, 95%CI[3.32, 4.87], <i>P<</i>0.00001), reduce TG(SMD = -0.60, 95%CI[-1.04, -0.16], <i>P</i> = 0.008), TC(SMD = -3.86, 95%CI[-6.37, -1.34], <i>P</i> = 0.003), and LDL-C(SMD = -1.54, 95%CI[-2.67, -0.42], <i>P</i> = 0.007), decrease plasma viscosity(SMD = -1.02, 95%CI[-1.58, -0.47], <i>P<</i>0.0003), whole blood low shear viscosity(SMD = -0.85, 95%CI[-1.21, -0.49], <i>P<</i>0.00001), whole blood high shear viscosity(SMD = -0.82, 95%CI[-1.44, -0.20], <i>P</i> = 0.009), and erythrocyte aggregation index(SMD = -1.00, 95%CI[-1.75, -0.25], <i>P</i> = 0.009), and bring down CRP(SMD = -1.39, 95%CI[-1.91, -0.86], <i>P</i><0.00001). …”

Basic characteristic of include studies. by Xiaoqi Wu (9503481)

“…Meta analysis results showed that, compared with conventional western medicine alone, STS combined with conventional western medicine could reduce the frequency (SMD = -2.61, 95%CI[-4.27, -0.96], <i>P</i> = 0.002) and duration (SMD = -4.01, 95%CI[-6.18, -1.84], <i>P</i> = 0.0003) of angina pectoris, improve ECG efficacy (OR = 3.61, 95%CI[2.79, 4.68], <i>P<</i>0.00001) and clinical symptom efficacy (OR = 4.02, 95%CI[3.32, 4.87], <i>P<</i>0.00001), reduce TG(SMD = -0.60, 95%CI[-1.04, -0.16], <i>P</i> = 0.008), TC(SMD = -3.86, 95%CI[-6.37, -1.34], <i>P</i> = 0.003), and LDL-C(SMD = -1.54, 95%CI[-2.67, -0.42], <i>P</i> = 0.007), decrease plasma viscosity(SMD = -1.02, 95%CI[-1.58, -0.47], <i>P<</i>0.0003), whole blood low shear viscosity(SMD = -0.85, 95%CI[-1.21, -0.49], <i>P<</i>0.00001), whole blood high shear viscosity(SMD = -0.82, 95%CI[-1.44, -0.20], <i>P</i> = 0.009), and erythrocyte aggregation index(SMD = -1.00, 95%CI[-1.75, -0.25], <i>P</i> = 0.009), and bring down CRP(SMD = -1.39, 95%CI[-1.91, -0.86], <i>P</i><0.00001). …”

Meta-analysis of adverse reactions. by Xiaoqi Wu (9503481)

“…Meta analysis results showed that, compared with conventional western medicine alone, STS combined with conventional western medicine could reduce the frequency (SMD = -2.61, 95%CI[-4.27, -0.96], <i>P</i> = 0.002) and duration (SMD = -4.01, 95%CI[-6.18, -1.84], <i>P</i> = 0.0003) of angina pectoris, improve ECG efficacy (OR = 3.61, 95%CI[2.79, 4.68], <i>P<</i>0.00001) and clinical symptom efficacy (OR = 4.02, 95%CI[3.32, 4.87], <i>P<</i>0.00001), reduce TG(SMD = -0.60, 95%CI[-1.04, -0.16], <i>P</i> = 0.008), TC(SMD = -3.86, 95%CI[-6.37, -1.34], <i>P</i> = 0.003), and LDL-C(SMD = -1.54, 95%CI[-2.67, -0.42], <i>P</i> = 0.007), decrease plasma viscosity(SMD = -1.02, 95%CI[-1.58, -0.47], <i>P<</i>0.0003), whole blood low shear viscosity(SMD = -0.85, 95%CI[-1.21, -0.49], <i>P<</i>0.00001), whole blood high shear viscosity(SMD = -0.82, 95%CI[-1.44, -0.20], <i>P</i> = 0.009), and erythrocyte aggregation index(SMD = -1.00, 95%CI[-1.75, -0.25], <i>P</i> = 0.009), and bring down CRP(SMD = -1.39, 95%CI[-1.91, -0.86], <i>P</i><0.00001). …”

Meta-analysis of CRP. by Xiaoqi Wu (9503481)

“…Meta analysis results showed that, compared with conventional western medicine alone, STS combined with conventional western medicine could reduce the frequency (SMD = -2.61, 95%CI[-4.27, -0.96], <i>P</i> = 0.002) and duration (SMD = -4.01, 95%CI[-6.18, -1.84], <i>P</i> = 0.0003) of angina pectoris, improve ECG efficacy (OR = 3.61, 95%CI[2.79, 4.68], <i>P<</i>0.00001) and clinical symptom efficacy (OR = 4.02, 95%CI[3.32, 4.87], <i>P<</i>0.00001), reduce TG(SMD = -0.60, 95%CI[-1.04, -0.16], <i>P</i> = 0.008), TC(SMD = -3.86, 95%CI[-6.37, -1.34], <i>P</i> = 0.003), and LDL-C(SMD = -1.54, 95%CI[-2.67, -0.42], <i>P</i> = 0.007), decrease plasma viscosity(SMD = -1.02, 95%CI[-1.58, -0.47], <i>P<</i>0.0003), whole blood low shear viscosity(SMD = -0.85, 95%CI[-1.21, -0.49], <i>P<</i>0.00001), whole blood high shear viscosity(SMD = -0.82, 95%CI[-1.44, -0.20], <i>P</i> = 0.009), and erythrocyte aggregation index(SMD = -1.00, 95%CI[-1.75, -0.25], <i>P</i> = 0.009), and bring down CRP(SMD = -1.39, 95%CI[-1.91, -0.86], <i>P</i><0.00001). …”

ECG efficacy funnel chart. by Xiaoqi Wu (9503481)

“…Meta analysis results showed that, compared with conventional western medicine alone, STS combined with conventional western medicine could reduce the frequency (SMD = -2.61, 95%CI[-4.27, -0.96], <i>P</i> = 0.002) and duration (SMD = -4.01, 95%CI[-6.18, -1.84], <i>P</i> = 0.0003) of angina pectoris, improve ECG efficacy (OR = 3.61, 95%CI[2.79, 4.68], <i>P<</i>0.00001) and clinical symptom efficacy (OR = 4.02, 95%CI[3.32, 4.87], <i>P<</i>0.00001), reduce TG(SMD = -0.60, 95%CI[-1.04, -0.16], <i>P</i> = 0.008), TC(SMD = -3.86, 95%CI[-6.37, -1.34], <i>P</i> = 0.003), and LDL-C(SMD = -1.54, 95%CI[-2.67, -0.42], <i>P</i> = 0.007), decrease plasma viscosity(SMD = -1.02, 95%CI[-1.58, -0.47], <i>P<</i>0.0003), whole blood low shear viscosity(SMD = -0.85, 95%CI[-1.21, -0.49], <i>P<</i>0.00001), whole blood high shear viscosity(SMD = -0.82, 95%CI[-1.44, -0.20], <i>P</i> = 0.009), and erythrocyte aggregation index(SMD = -1.00, 95%CI[-1.75, -0.25], <i>P</i> = 0.009), and bring down CRP(SMD = -1.39, 95%CI[-1.91, -0.86], <i>P</i><0.00001). …”

Meta-analysis of blood lipid. by Xiaoqi Wu (9503481)

“…Meta analysis results showed that, compared with conventional western medicine alone, STS combined with conventional western medicine could reduce the frequency (SMD = -2.61, 95%CI[-4.27, -0.96], <i>P</i> = 0.002) and duration (SMD = -4.01, 95%CI[-6.18, -1.84], <i>P</i> = 0.0003) of angina pectoris, improve ECG efficacy (OR = 3.61, 95%CI[2.79, 4.68], <i>P<</i>0.00001) and clinical symptom efficacy (OR = 4.02, 95%CI[3.32, 4.87], <i>P<</i>0.00001), reduce TG(SMD = -0.60, 95%CI[-1.04, -0.16], <i>P</i> = 0.008), TC(SMD = -3.86, 95%CI[-6.37, -1.34], <i>P</i> = 0.003), and LDL-C(SMD = -1.54, 95%CI[-2.67, -0.42], <i>P</i> = 0.007), decrease plasma viscosity(SMD = -1.02, 95%CI[-1.58, -0.47], <i>P<</i>0.0003), whole blood low shear viscosity(SMD = -0.85, 95%CI[-1.21, -0.49], <i>P<</i>0.00001), whole blood high shear viscosity(SMD = -0.82, 95%CI[-1.44, -0.20], <i>P</i> = 0.009), and erythrocyte aggregation index(SMD = -1.00, 95%CI[-1.75, -0.25], <i>P</i> = 0.009), and bring down CRP(SMD = -1.39, 95%CI[-1.91, -0.86], <i>P</i><0.00001). …”

Adverse reactions. by Xiaoqi Wu (9503481)

“…Meta analysis results showed that, compared with conventional western medicine alone, STS combined with conventional western medicine could reduce the frequency (SMD = -2.61, 95%CI[-4.27, -0.96], <i>P</i> = 0.002) and duration (SMD = -4.01, 95%CI[-6.18, -1.84], <i>P</i> = 0.0003) of angina pectoris, improve ECG efficacy (OR = 3.61, 95%CI[2.79, 4.68], <i>P<</i>0.00001) and clinical symptom efficacy (OR = 4.02, 95%CI[3.32, 4.87], <i>P<</i>0.00001), reduce TG(SMD = -0.60, 95%CI[-1.04, -0.16], <i>P</i> = 0.008), TC(SMD = -3.86, 95%CI[-6.37, -1.34], <i>P</i> = 0.003), and LDL-C(SMD = -1.54, 95%CI[-2.67, -0.42], <i>P</i> = 0.007), decrease plasma viscosity(SMD = -1.02, 95%CI[-1.58, -0.47], <i>P<</i>0.0003), whole blood low shear viscosity(SMD = -0.85, 95%CI[-1.21, -0.49], <i>P<</i>0.00001), whole blood high shear viscosity(SMD = -0.82, 95%CI[-1.44, -0.20], <i>P</i> = 0.009), and erythrocyte aggregation index(SMD = -1.00, 95%CI[-1.75, -0.25], <i>P</i> = 0.009), and bring down CRP(SMD = -1.39, 95%CI[-1.91, -0.86], <i>P</i><0.00001). …”

Meta-analysis of ECG efficacy. by Xiaoqi Wu (9503481)

“…Meta analysis results showed that, compared with conventional western medicine alone, STS combined with conventional western medicine could reduce the frequency (SMD = -2.61, 95%CI[-4.27, -0.96], <i>P</i> = 0.002) and duration (SMD = -4.01, 95%CI[-6.18, -1.84], <i>P</i> = 0.0003) of angina pectoris, improve ECG efficacy (OR = 3.61, 95%CI[2.79, 4.68], <i>P<</i>0.00001) and clinical symptom efficacy (OR = 4.02, 95%CI[3.32, 4.87], <i>P<</i>0.00001), reduce TG(SMD = -0.60, 95%CI[-1.04, -0.16], <i>P</i> = 0.008), TC(SMD = -3.86, 95%CI[-6.37, -1.34], <i>P</i> = 0.003), and LDL-C(SMD = -1.54, 95%CI[-2.67, -0.42], <i>P</i> = 0.007), decrease plasma viscosity(SMD = -1.02, 95%CI[-1.58, -0.47], <i>P<</i>0.0003), whole blood low shear viscosity(SMD = -0.85, 95%CI[-1.21, -0.49], <i>P<</i>0.00001), whole blood high shear viscosity(SMD = -0.82, 95%CI[-1.44, -0.20], <i>P</i> = 0.009), and erythrocyte aggregation index(SMD = -1.00, 95%CI[-1.75, -0.25], <i>P</i> = 0.009), and bring down CRP(SMD = -1.39, 95%CI[-1.91, -0.86], <i>P</i><0.00001). …”

Proteomic analysis of the response of <i>Trichinella spiralis</i> muscle larvae to exogenous nitric oxide by Xiaoli Wang (46677)

“…<i>spiralis</i>. Herein, we applied label-free analysis to investigate the effect of sodium nitroprusside (SNP, a NO donor compound) on the proteome of <i>T</i>. …”

Table 2_Tofacitinib extends survival in a mouse model of ALS through NK cell-independent mechanisms.xlsx by Lillia A. Baird (10575941)

“…Tofacitinib, an FDA-approved janus kinase (Jak) and signal transducer and activator (STAT) pathway inhibitor, reduces NK cytotoxicity and decreases overall levels in peripheral blood and may represent a potential ALS therapy. …”

Table 1_Tofacitinib extends survival in a mouse model of ALS through NK cell-independent mechanisms.xlsx by Lillia A. Baird (10575941)

“…Tofacitinib, an FDA-approved janus kinase (Jak) and signal transducer and activator (STAT) pathway inhibitor, reduces NK cytotoxicity and decreases overall levels in peripheral blood and may represent a potential ALS therapy. …”

Instantaneous transcription rate in single yeast cells correlates with growth across the cell cycle. by C. J. Zopf (437735)

“…(C) Mean instantaneous growth and protein production rates are lower in G1 and peak in S/G2/M. …”

Effects of Light Stress (LS) on subsequent saccharin intake and homecage activity in BL/6J mice. by Martin C. Schweizer (267501)

The alternate biochemical experiments to test for apoptosis under all the growth conditions and markers for oxidative stress. by Hung-Chih Hsu (479317)

“…HIG-82 synoviocytes (3×10⁵/100-mm cultured dishes) were treated with FC, MFD and FD for 48 h or 500 nM Epi (a positive control) for 48 h. …”

Working model for AICAR-mediated regulation of hepatic Fet-A expression. by Vishal Kothari (12511601)