Survival, bacterial clearance and thrombocytopenia are improved in polymicrobial sepsis by targeting nuclear transport shuttles by Ruth Ann Veach (334052)

“…This storm is mediated by stress-responsive transcription factors that are ferried to the nucleus by nuclear transport shuttles importins/karyopherins. We studied the impact of simultaneously targeting two of these shuttles, importin alpha 5 (Imp α5) and importin beta 1 (Imp β1), with a cell-penetrating Nuclear Transport Modifier (NTM) in a mouse model of polymicrobial sepsis. …”

Table1_Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction.DOCX by Zabed Mahmud (12827819)

“…<p>Small molecule cardiac troponin activators could potentially enhance cardiac muscle contraction in the treatment of systolic heart failure. We designed a small molecule, RPI-194, to bind cardiac/slow skeletal muscle troponin (Cardiac muscle and slow skeletal muscle share a common isoform of the troponin C subunit.) …”

Image1_Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction.pdf by Zabed Mahmud (12827819)

“…<p>Small molecule cardiac troponin activators could potentially enhance cardiac muscle contraction in the treatment of systolic heart failure. We designed a small molecule, RPI-194, to bind cardiac/slow skeletal muscle troponin (Cardiac muscle and slow skeletal muscle share a common isoform of the troponin C subunit.) …”

The Tissue-Specific RNA Binding Protein T-STAR Controls Regional Splicing Patterns of <i>Neurexin</i> Pre-mRNAs in the Brain by Ingrid Ehrmann (191911)

“…Mice null for T-STAR developed normally and were fertile, surprisingly, given the high expression of T-STAR in the testis and the brain, and the known infertility and pleiotropic defects of Sam68 null mice. Using a transcriptome-wide search for splicing targets in the adult brain, we identified T-STAR protein as a potent splicing repressor of the alternatively spliced segment 4 (AS4) exons from each of the <i>Neurexin1-3</i> genes, and exon 23 of the <i>Stxbp5l</i> gene. …”

Image3_Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction.pdf by Zabed Mahmud (12827819)

“…<p>Small molecule cardiac troponin activators could potentially enhance cardiac muscle contraction in the treatment of systolic heart failure. We designed a small molecule, RPI-194, to bind cardiac/slow skeletal muscle troponin (Cardiac muscle and slow skeletal muscle share a common isoform of the troponin C subunit.) …”

DataSheet1_Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction.docx by Zabed Mahmud (12827819)

“…<p>Small molecule cardiac troponin activators could potentially enhance cardiac muscle contraction in the treatment of systolic heart failure. We designed a small molecule, RPI-194, to bind cardiac/slow skeletal muscle troponin (Cardiac muscle and slow skeletal muscle share a common isoform of the troponin C subunit.) …”

The use of information and communication technology devices as part of the solo eating experience by Mailin Lemke (10052141)

“…</div><div><br></div><div>We used a non-probability, convenience sample for this study. …”

SIV-specific CD8 T cell response localizes to the gut and secondary lymphoid tissues during SIVΔnef vaccination. by Sama Adnan (693011)

“…<p>(A) CM9-specific CD8 T cells were maintained across tissues between weeks 5 and 20 post-SIVΔnef vaccination. …”

Pearson clusters and fPCA considering all protein-coding genes. by Leo Zeitler (13775500)

“…<p>(A) The silhouette plot clearly indicates that the data can be best divided into two clusters, and creating more groups would only decrease the difference between each cluster. …”

Cort expression leads to proteasome-mediated degradation of Mtrm in cell culture. by Zachary J. Whitfield (453399)

“…Myc-Mtrm band intensity is quantified as in (A). For qPCR, <i>mtrm</i> transcript levels are normalized to <i>actin5c</i> and shown relative to empty vector. …”

Role of the Number of Microtubules in Chromosome Segregation during Cell Division - Fig 6 by Zsolt Bertalan (790472)

“…This is summarized in (c) showing the time <i>t</i>_{<i>p</i> = 1/2} for which the congression/bi-orientation probability is one half. …”

DataSheet1_Molecular dynamics study of tropical calcific pancreatitis (TCP) associated calcium-sensing receptor single nucleotide variation.docx by Ashish Shrivastava (5325164)

“…The results of molecular dynamic simulations showed that the mutations P163R, I427S, D433H, and V477A caused conformational changes and decreased the stability of protein structures. …”

DataSheet_6_Evaluating NetMHCpan performance on non-European HLA alleles not present in training data.csv by Thomas Karl Atkins (17791715)

“…Thus, investigating the composition of training datasets used in machine learning models with healthcare applications is vital to ensure equity. Two such machine learning models are NetMHCpan-4.1 and NetMHCIIpan-4.0, used to predict antigen binding scores to major histocompatibility complex class I and II molecules, respectively. …”

Table_3_Impact of mutagenesis and lateral gene transfer processes in bacterial susceptibility to phage in food biocontrol and phage therapy.docx by Júlia López-Pérez (17057421)

“…This percentage was lower in FOOD, with 4.3% of isolates not susceptible to at least two of the three phages after seven days at 4°C following phage treatment. …”

DataSheet_1_Evaluating NetMHCpan performance on non-European HLA alleles not present in training data.pdf by Thomas Karl Atkins (17791715)

“…Thus, investigating the composition of training datasets used in machine learning models with healthcare applications is vital to ensure equity. Two such machine learning models are NetMHCpan-4.1 and NetMHCIIpan-4.0, used to predict antigen binding scores to major histocompatibility complex class I and II molecules, respectively. …”

Relationship between cold sensitivity and inhibitor sensitivity of primary HIV-1 envelope glycoproteins. by Hillel Haim (216672)

“…The 26 envelope glycoproteins included in the cohort are listed in the <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002101#s4" target="_blank">Materials and Methods</a> section. *, Two-tailed T-Test P value 0.000112. (<b>C</b>) Correlation between sCD4 sensitivity and the product of CD4-Ig binding to cell-surface envelope glycoproteins and cold sensitivity. …”

Table_1_Impact of mutagenesis and lateral gene transfer processes in bacterial susceptibility to phage in food biocontrol and phage therapy.docx by Júlia López-Pérez (17057421)

“…This percentage was lower in FOOD, with 4.3% of isolates not susceptible to at least two of the three phages after seven days at 4°C following phage treatment. …”

DataSheet_7_Evaluating NetMHCpan performance on non-European HLA alleles not present in training data.xlsx by Thomas Karl Atkins (17791715)

“…Thus, investigating the composition of training datasets used in machine learning models with healthcare applications is vital to ensure equity. Two such machine learning models are NetMHCpan-4.1 and NetMHCIIpan-4.0, used to predict antigen binding scores to major histocompatibility complex class I and II molecules, respectively. …”

Image_1_Impact of mutagenesis and lateral gene transfer processes in bacterial susceptibility to phage in food biocontrol and phage therapy.tif by Júlia López-Pérez (17057421)

“…This percentage was lower in FOOD, with 4.3% of isolates not susceptible to at least two of the three phages after seven days at 4°C following phage treatment. …”

DataSheet_1_Impact of mutagenesis and lateral gene transfer processes in bacterial susceptibility to phage in food biocontrol and phage therapy.docx by Júlia López-Pérez (17057421)

“…This percentage was lower in FOOD, with 4.3% of isolates not susceptible to at least two of the three phages after seven days at 4°C following phage treatment. …”