Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Despite the marked decrease in VAT T cells and B cells, systemic metabolic parameters are not altered in CD11c-MyD88 KO DIO Mice. by Manikandan Subramanian (789856)

Knockdown of 1A6/DRIM results in a decrease in 47S rRNA. by Qunhui Peng (358982)

Electron Distribution in the Nonclassical Bis(dithiolene) Electron Transfer Series [M(CO)₂(S₂C₂Me₂)₂]^0/1-/2- (M =... by Dmitry V. Fomitchev (2962923)

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CHNRI's conceptual framework showing key steps required to get from investments in health research options to decrease in burden of death, disease, or disability. by Igor Rudan (150101)

Deletion of <i>sagA</i> alone results in a decrease in nasopharyngeal infection. by Blake A. Shannon (14197601)

IGFBP2 blockade decreased tumor growth and improved survival in the mouse GBM model. by Yunmian Liu (7439480)

RhoA-induced suppression of the HSR decreases cell stress resistance and induces cell death via apoptosis. by Roelien A. M. Meijering (217816)

Flow chart from invitation to analyses. *For administrative reasons HbA1c was not available for a small subset of the population. by Martin Gillies Banke Rasmussen (10227291)

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Pairwise correlations of excitatory neurons in APP/PS1 mice are decreased in dCA1, but increased in vCA1. by Udaysankar Chockanathan (18510288)

Resveratrol decreases cytokine–induced pro-inflammatory mediators production more efficiently than 5-ASA, in HT-29 cells. by Diana Serra (455187)

Decreased epithelial PGR expression in <i>Arid1a</i>^<i>d/d</i> mice. by Tae Hoon Kim (128536)

IFN-β signalling pathway stimulation by Poly(I:C) decreased 5’terminally deleted CVB3 RNA forms viral loads, cardiac lesions and mortality in DBA/2J mice. by Domitille Callon (17723936)

AQP1 abundance. by Sophie Constantin Lütken (689916)

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AQP4 abundance. by Sophie Constantin Lütken (689916)

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Changes in renal function. by Sophie Constantin Lütken (689916)

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