DataSheet_1_Regulation of SPDEF expression by DNA methylation in advanced prostate cancer.pdf by Mousa Vatanmakanian (15171089)

“…</p>Results<p>In this report, we observed that: a) there is a gradual decrease in SPDEF expression with a concomitant increase in methylated CpG sites within the SPDEF gene during prostate cancer progression from lower to higher Gleason grade; b) Expression of DNMT’s (DNMT1, 3a and 3b) is increased during prostate cancer progression, and there is an inverse correlation between SPDEF and DNMT expression; c) SPDEF levels are decreased in RC77/T, a line of PCa cells from African American origin similar to PC3 and DU145 cells (CRPC cells), as compared to LNCaP cells , a line of androgen dependent cells,; d) the 5′ CpG island of SPDEF gene are hypermethylated in SPDEF-negative CRPC ( PC3, DU145 and RC77/T) cell lines but the same regions are hypomethylated in SPDEF-positive castrate sensitive (LNCaP) cell line ; (e) expression of SPDEF in PCa cells lacking SPDEF decreases cell migration and invasion, but has no significant effect on cell proliferation, and; (f) treatment with the demethylating agent, 5-aza-2′-deoxycytidine, or silencing of the DNMT’s by siRNA, partially restores SPDEF expression in SPDEF-negative PCa cell lines, and decreases cell migration and invasion.…”

Effects of stochastic channel gating alter the response to stellate cells to naturalistic stimuli. by Joshua T. Dudman (267282)

“…<p>(A,B) Plot of mean spike frequency (A) and coefficient of variation of the ISI distribution (B) as a function of the mean and standard deviation of band limited white noise inputs obtained from 5 s duration simulations (N = 384). …”

GBE treatment improved mitochondrial capacity. by Virginie Rhein (243241)

“…<b>B</b>) Two-way ANOVA revealed a significant Aβ-induced decrease of the total cellular respiration in APP cells compared to that of control cells (group effect: control vs. …”

DELTA-1/NOTCH signaling in the caudal spinal cord of chick embryos. by Barbara Hämmerle (36261)

“…In contrast, control pCIG transfected cells do not altere <i>Hes5.1</i> expression (E–E′). F–F′. Confocal projection over 50 µm taken from a dorsal view point of the prospective spinal cord at the level of the 12th–14^th somites counted from rostral of an embryo which was electroporated with the antisense morpholino oligo Mo2-cDelta1 at HH10 stage and allowed to develop until HH12/13. …”

Classic lipid profile at baseline (T0) and after six months (T6). by Zahra Lotfollahi (13531402)

“…For rosuvastatin-clopidogrel (p = 7.4E-9); for rosuvastatin-ticagrelor (p = 3.7E-9); for simvastatin/ezetimibe-clopidogrel (p = 1.4E-8); and for simvastatin/ezetimibe-ticagrelor (p = 1.8E-9). (B) LDL-C at T0 and at T6 with combined therapy. Significant decrease was observed with all the combined therapies. …”

Removal of Sialic Acids from Human Sebocytes by Sialidase Increases Their Susceptibility to <i>P. acnes.</i> by Teruaki Nakatsuji (39298)

“…The sebocytes were pre-treated with 10 µg/ml of purified recombinant sialidase (green, a), GFP (green, b) or an equal volume of PBS (vehicle) (purple) at pH 6 for 2 h. …”

Dependence of the Conceptual Distance <i>d</i>(<i>N</i>) on Dataset Size for Different Document Removal Strategies. by Artem Chumachenko (21681455)

“…<p>For two target concept pairs –“Pair 1” (blue palette) and “Pair 2” (red palette) – the distance <i>d</i>(<i>N</i>) is calculated over a range of data set sizes from to , with <i>N</i> increasing in steps of . …”

Determination of optimal allopregnanolone treatment regimen. by Shuhua Chen (11649)

“…However, the 3/week/6 months treatment induced a significant decrease in neurogenesis. The percentage of increase is presented as mean ± SEM * <i>P</i><0.01. …”

Modulation of HCN and calcium currents by extracellular pH. by Saju Balakrishnan (58265)

“…The currents were evoked by voltage steps to -110 and -40 mV, respectively, from a holding potential of -70 mV (close to resting potential measured in CA1 neurons). …”

Curcumin suppresses constitutively activated NFκB activity, down regulates Bcl-_xl and causes mitochondrial membrane depolarization in AtT20 cells. by Madhavi Latha Yadav Bangaru (365520)

“…However, treatment with 50 µM curcumin, that caused a decrease in Bcl-xL levels, significantly increased the intensity of green fluorescence. …”

SP-D agglutinates and inhibits infectivity of HIV. by Jens Madsen (391091)

“…<b>C</b>: Infectious HIV BaL particles were preincubated at a pH of 7.4 (black) or 5.0 (white) in the presence and absence of the indicated concentrations of SP-D (1–10 µg/mL) before inoculation with PM1 cells. …”

MD and TL of DiD-labelled TBEV vesicles exhibiting directional mobility increased with time p.i.. by Maja Potokar (510981)

“…However, a significant increase was observed for MD (in µm) for DM periods (white bars): from 1.69±0.27 (2 h) to 2.68±0.23 (4 h; **<i>P</i><0.01) and 2.42±0.09 (18 h; *<i>P</i><0.05) and small, but significant decrease for NDM periods: 0.48±0.02 µm (2 h), 0.43±0.01 µm (4 h) and 0.44±0.001 µm (18 h) (<i>**P</i><0.01, <i>***P</i><0.001 (grey bars) (C). …”

Longitudinal changes of retinal thickness. by Marco Augustin (3202311)

“…(E,F) Longitudinal evaluation of the TR thickness for the exemplary mice shown in (A-D). (G) The mean TR thickness clustered by month showed a significant thinning between the age of 2 and 5 months and older, while a significant thinning of the outer retina (OR) was observed between the at age of 2 and 4 months. …”

EGR1 overexpression prevents the downregulation of tendon-associated gene expression in tension released engineered tendons. by Ludovic Gaut (3335541)

“…<p>(<b>A</b>) Two week-old fibrin gel constructs made of mouse C3H10T1/2 cells or C3H10T1/2-EGR1 cells were analyzed for tendon gene expression by RT-q-PCR analyses. …”

GA did not induce neuronal death in absence of astrocytes. by Silvia Olivera-Bravo (349736)

“…<p>Isolated striatal neuronal cultures were employed to investigate the mechanism of GA-induced neurotoxicity. <b>A:</b> Phase contrast of E18 striatal neurons at 5 DIV exposed to vehicle or 5 mM GA (pH 7.4, 24 h). …”

The role of hypo- and hypercoagulability in plaque fibrosis. by Julian I. Borissoff (280594)

“…Hypocoagulable FII^−/+:ApoE^−/− mice lesions showed a pro-fibrotic appearance, testified by increased collagen deposition (24.4±14.1% vs. 12.0±6.1% of total plaque area in ApoE^−/− mice, n = 10 per group, p = 0.0435) and α-smooth muscle actin content (25.5±13.6% vs. 6.9±3.2% of total plaque area in ApoE^−/− mice, n = 10 per group, p = 0.0003) (<b>B, C</b>). …”

Supplementary Material for: Characteristics of Rosacea and Similar Diseases in Patients Wearing Face Masks by Nobeyama Y. (12811124)

“…The monthly number of patients with rosacea and demodicosis showed two peaks from May to June and in October, during which monthly mean temperature was approximately 20°C (68°F). …”

Posterior Lobes contribute blood cells to the adult hematopoietic hub. by Aditya Kanwal (11250792)

“…Quantitative analyses denoting a decrease in the number of lineage traced cells in the adult hub with the change in shifting regime. …”

Dynamics of attractors during loss and recovery of response for the population studied. by Sarah L. Eagleman (7586465)

“…<p>A) The average ellipse radius ratio (ERR) for all patients appears to decrease gradually as patients approach loss of response (LOR), and continues to decrease in value as anesthetic depth increases (A, left). …”

Combination therapy restores wound neovascularization partially though PC-mediated vasculogenesis. by Robert J. Allen Jr. (540312)

“…<b>C</b>) BrdU-labeling of PCs in the presence of AMD3100 demonstrates only minor, non-significant, inhibition in PC proliferation (15.4±3.3% decrease, p = 0.06). …”