Changes associated with kidney fibrosis and effects of MN705 treatment on TGF- by Wencheng Jin (13136262)

Subjects:

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Cu/Zn siRNA decreased Cu/Zn SOD-positive spermatogonia and increased oxidative damage and mortality. by Fritzie T. Celino (229602)

AQP1 overexpression decreased high glucose-induced mitochondrial ROS generation and high glucose-induced phenomena. by Kiminori Sada (3158298)

Injection of the HDAC inhibitor TSA or the HAT inhibitor Garcinol transiently increases or decreases protein acetylation in the honeybee brain. by Katja Merschbaecher (306782)

High glucose induced intracellular accumulation of methylglyoxal, which in turn led to decreased levels of HIF-1α. by Carla Figueira Bento (359400)

Decreased peripheral blood mononuclear cells (PBMC) activation in patients with head and neck squamous cell carcinoma (HNSCC). by Camilla Rydberg Millrud (112755)

KCl pulse decreased membrane, but increased nuclear, detection of NHE1 in b.End3 endothelial cells. by Erika Liktor-Busa (3328125)

Compared to vorinostat, M344 decreases pancreatic cancer cell proliferation more effectively for a longer duration. by Shelby M. Knoche (13833807)

Decreased Sho levels correlate with the amount of PrP^Sc C2 fragment present in prion-infected animals. by Joel C. Watts (195735)

“…Infection with RML prions resulted in the largest decrease in Sho levels and the highest amount of PrP^Sc C2 fragment (determined after digestion with thermolysin (TL) and PNGaseF). …”

Extensive lipid accumulation and proteins loss explains the decreased sinking velocity in starving <i>Phaeodactylum tricornutum.</i> by Yanqi Wu (489316)

The screening process of MN705. by Wencheng Jin (13136262)

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miR-143 overexpression decreases human colon carcinoma cell tumor xenograft growth in nude mice. by Pedro M. Borralho (217909)

Changes of anti-oxidative enzyme and oxidative stress after in a mouse model of kidney fibrosis. by Wencheng Jin (13136262)

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Changes related to kidney staining in UUO mouse model. by Wencheng Jin (13136262)

Subjects:

Changes associated with kidney fibrosis in TGF- by Wencheng Jin (13136262)

Subjects: