Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibi... by Jinxin Che (791250)

The decrease in embryonic survival after stress coincides with a decrease in oocyte and embryo size. by Sarah Fausett (11812818)

Torsional strength decreased with Db/Db genotype. by Devorah M. Natelson (8807576)

Apoptosis inhibitor impeded larval invasion of Caco-2 monolayer. by Qi Qi Lu (17721401)

Subjects:

Image_2_SIRT1 haplo-insufficiency results in reduced cortical bone thickness, increased porosity and decreased estrogen receptor alpha in bone in adult 129/Sv female mice.tif by Hanna Artsi (777390)

“…Decreased bone estrogen receptor alpha (ERα) was observed in Sirt1^+/Δ compared to WT female mice and was significantly higher in Sirt1 over-expressing C3HT101/2 murine mesenchymal stem cells. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Kcnk5b activity induces IP₃R-mediated Ca²⁺ release from the ER. by Xiaowen Jiang (8291814)

Data_Sheet_1_Triadin Decrease Impairs the Expression of E-C Coupling Related Proteins in Muscles of MPTP-Induced Parkinson’s Disease Mice.PDF by Min Hyung Seo (10684422)

“…In this study, the expression levels of the components of RYR channels decreased in the quadriceps femoris muscle of MPTP-induced PD mice and in C2C12 cells treated with 1-methyl-4-phenylpyridinium. …”

Structural Studies of the <i>Methylosinus trichosporium</i> OB3b Soluble Methane Monooxygenase Hydroxylase and Regulatory Component Complex Reveal a Transient Substrate Tunnel by Jason C. Jones (9191264)

“…The kinetics of reaction of O₂ with the diferrous sMMOH:MMOB complex in solution show that use of the MMOB V41R variant decreases the rate constant for O₂ binding >25000-fold without altering the component affinity. …”

Structural Studies of the <i>Methylosinus trichosporium</i> OB3b Soluble Methane Monooxygenase Hydroxylase and Regulatory Component Complex Reveal a Transient Substrate Tunnel by Jason C. Jones (9191264)

“…The kinetics of reaction of O₂ with the diferrous sMMOH:MMOB complex in solution show that use of the MMOB V41R variant decreases the rate constant for O₂ binding >25000-fold without altering the component affinity. …”

Decrease in striatal DA release in D2-cKO mice without changes in DA reuptake kinetics or in striatal surface DAT levels. by Nicolas Giguère (7310270)

<i>Emx1</i>-cKO mice lack the neocortex. by Sathish Venkataramanappa (10331993)

Decreased fetal weight in CrryshRNA mice. by Manu Banadakoppa (9199271)

“…<p>Fetal and placental weights were measured at 17.5 dpc soon after euthanasia (n = 5–7), A) Average fetal weight was significantly reduced (<i>p</i> = 0.048) in CrryshRNA mice compared to control group B) Average placental weight was not different between the two groups C) Fetal-placental weight ratio was significantly decreased (<i>p</i> = 0.045) in Crry shRNA mice compared to control mice.…”

RcbA and RcbB co-operatively decrease motility independent of CaCl₂ concentration. by Shobnom Mustaree (21728815)

Silencing of <i>NbNBR1</i> decreases the accumulation of βC1. by Tingting Zhou (163678)

Effects of nuclear hormone treatments on <i>kcnk5b</i>, <i>rcan2</i>, and control genes in pectoral fin buds and adult fins and sufficiency/necessity experiments for <i>rcan2</i>. by Xiaowen Jiang (8291814)

MtRNA binding to RIG-I, DNA mtDNA editing and context analysis. by Pierre Khalfi (7868252)

Subjects:

Inhibition of Cu²⁺-mediated of LDL oxidation by cannabis extracts. by Bruno Musetti (9527085)

Subjects:

Total number of CHWs in scenario C when model parameters are increased or decreased by 10%. by Clara Champagne (5634644)