Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction by Daohai Du (1714372)

<i>XE2F</i> Lipofection Inhibits Xotx2 Translation and the Generation of Bipolar Cells by Sarah Decembrini (20293)

“…<div><p>(A–C) st. 40-lipofected retinas. Lipofected cells are traced by GFP (green), Xotx2 immunostaining in red. …”

Image 2_Pharmacokinetics of cannabidiol and its two main phase I metabolites in Connemara ponies.tiff by Kata Wermer (21614717)

“…The pharmacokinetic parameters for CBD were C_max = 31.472 ± 8.080 ng/mL, t_max = 2.111 ± 0.928 h, t_1/2 = 12.563 ± 3.054 h, and Vz/F = 198.757 ± 49.123 L/kg.…”

Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy by Eleni N. Tsakiri (6614297)

“…Ubiquitous or tissue specific proteasome dysfunction triggered systemic proteome instability and activation of PN modules, including macroautophagy/autophagy, molecular chaperones and the antioxidant cncC (the fly ortholog of NFE2L2/Nrf2) pathway. Also, proteasome KD increased genomic instability, altered metabolic pathways and severely disrupted mitochondrial functionality, triggering a cncC-dependent upregulation of mitostatic genes and enhanced rates of mitophagy. …”

Hematopoietic bone marrow (BM) colony-forming units from exposed and shielded humerus. by Marco Valente (770660)

Immunohistochemical staining showing the expression of phosphorylated p38 in the mouse renal tubulointerstitial area after UUO and administration of p38 MAPK inhibitor. by Jeonghwan Lee (286889)

“…<p>Scale bar = 50 μm (original magnification x300). (A) Sham-operated group. (B) UUO-operated group administered 20% DMSO vehicle. …”

The effect of lockdown on the COVID-19 epidemic in Brazil: evidence from an interrupted time series design by Lucas Silva (7233020)

DataSheet_1_Distribution and Variation of Serotypes and Pneumococcal Surface Protein A Clades of Streptococcus pneumoniae Strains Isolated From Adult Patients With Invasive Pneumoc... by Bin Chang (3328344)

“…PspA clades 1–6 were detected in 786 (40.5%), 291 (15.0%), 443 (22.8%), 369 (19.0%), 33 (1.7%), and 6 (0.3%) strains, respectively. …”

LCoE in 2030 to 2050 assuming 10% p.a. WACC by ESC and exporter. by Johannes Hampp (14593021)

Image_5_Ultraviolet-B Radiation Represses Primary Root Elongation by Inhibiting Cell Proliferation in the Meristematic Zone of Arabidopsis Seedlings.pdf by Maria Luján Sheridan (12288950)

Immunohistochemistry of the white matter in the <i>centrum semiovale</i> of the cerebrum. by Theresa Störk (7465622)

“…Inset shows NogoA⁺ oligodendrocytes at a higher magnification. (NogoA). (C) Statistical analysis of NogoA-immunohistochemstry shows significantly decreased numbers of myelinating oligodendrocytes in the <i>centrum semiovale</i> of the affected Schnauzer puppies (n = 4, no.1, 2, 3 and 4) in comparison to age matched control animals (n = 4, no. 1009, 1010, 1011 and 1012). …”

Monitoring Mitochondrial Complex-I Activity Using Novel PET Probe ¹⁸F-BCPP-EF Allows Early Detection of Radiotherapy Effect in Murine Squamous Cell Carcinoma by Chieko Murayama (3710143)

“…<div><p>Objectives</p><p>Aerobic glycolysis, the main pathway of energy production in tumors (Warburg effect) allows detection of tumors by positron emission tomography (PET) using ¹⁸F-fluoro-2-deoxy-D-glucose (¹⁸F-FDG). Since ionizing radiation (IR) is reported to switch aerobic glycolysis to mitochondrial oxidative phosphorylation, radiotherapeutic efficacy was monitored by the activity of mitochondrial complex I (MC-I), using a new PET probe ¹⁸F-BCPP-EF, ¹⁸F-2-tert-butyl-4-chloro-5-{6-[2-(2-fluoro-ethoxy)-ethoxy] -pyridine-3-ylmethoxy}-2H-pyridazin-3-one, compared with ¹⁸F-FDG uptake and the apoptosis index.…”

Ratanasampil is more effective than flunarizine in relieving migraine by Aiqin Zhu (11580439)

“…The serum levels of biomarkers, including 5-HT, BDNF, NGF and β-EP, significantly elevated after eight weeks of treatment with RNSP, whereas the level of CGRP significantly decreased. …”

DataSheet2_Contact varroacidal efficacy of lithium citrate and its influence on viral loads, immune parameters and oxidative stress of honey bees in a field experiment.PDF by Nemanja M. Jovanovic (11606566)

“…Our experiment was performed on four groups, each consisting of seven colonies. Two groups were treated with the test compound, one receiving 5 mM and the other 10 mM of Li-cit; the third received oxalic acid treatment (OA group) and served as positive control, and the fourth was negative control (C group), treated with 50% w/v pure sucrose-water syrup. …”

Modeling of multisensory speech perception with causal inference. by John F. Magnotti (3752563)

Data_Sheet_1_Molecular modeling and phylogenetic analyses highlight the role of amino acid 347 of the N1 subtype neuraminidase in influenza virus host range and interspecies adapta... by Stefano Elli (1325028)

“…The Y347N substitution facilitates hydrolysis of human-type substrates by resolving steric conflicts of the Neu5Ac2–6Gal moiety with the bulky side chain of Y347, decreasing the free energy of substrate binding, and increasing the solvation of the Neu5Ac2–6Gal bond. …”

Table_1_Effect of plantation age on plant and soil C:N:P stoichiometry in Kentucky bluegrass pastures.DOCX by Xiaoxing Wei (11831594)

“…Root N:P showed an increasing trend from 2 to 6 years of plantation age and relative stability from 6 to 9 years of plantation age, whereas root C:N and C:P showed decreasing trends from 2 to 9 years of plantation age. …”

The effects of low-carbohydrate diets on cardiovascular risk factors: A meta-analysis by Tingting Dong (314380)

“…The change in the body weight in the observation groups was -1.58kg (95% confidence interval -1.58 to -0.75); with for less than 6 months of intervention,this change was -1.14 kg (95% confidence interval -1.65 to -0.63),and with for 6–11 months of intervention, this change was -1.73kg (95% confidence interval -2.7 to -0.76). The change in the systolic blood pressure of the observation group was -1.41mmHg (95% confidence interval—2.26 to -0.56); the change in diastolic blood pressure was -1.71mmHg (95% confidence interval—2.36 to -1.06); the change in plasma HDL-C levels was 0.1mmHg (95% confidence interval 0.08 to 0.12); and the change in serum total cholesterol was 0.13mmol/l (95% confidence interval 0.08 to 0.19). …”

Mean histopathological severity scores in control, paraquat and MPTP-treated groups of C57BL/6J male mice. by Richard Jay Smeyne (3278886)

“…Serial sections through the SNpc were evaluated qualitatively and the group mean severity grades are plotted. Grades 0 to 5 reflect increasing intensity of staining for Iba-1, AmCuGg, GFAP and decreased staining intensity of TH.…”

Binding of BMP-7 to BMPR2 phosphorylates R-SMAD1/5/8 which activates PI3K. by Crystal Rocher (500661)

“…<p>Representative western blot bands (<b>A</b>) are shown of p-SMAD1/5/8 and β-actin with densitometric analysis of P-SMAD1/5/8 showing a significant increase of expression in the ACM+BMP7 group and a significant decrease of expression in the ACM and ACM+BMP7+Foll groups. …”