AF17 upregulates basal, but not aldosterone-stimulated expression of <i>αENaC</i> in M-1 cells. by Hongyu Wu (104579)

“…Vec. n = 4 (<b><i>B</i></b>). <b><i>C-D.</i></b> Knockdown of AF17 mRNA expression decreases basal <i>αENaC</i> transcription. …”

Image_2_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Kv7.4 channels co-expressed with wild-type (WT) CaM show inhibited activation when intracellular calcium levels increase, while Kv7.4 channels co-expressed with CaM₁₂₃₄ or CaM₃ are insensitive to calcium. Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

(A) Least squares mean and 95% confidence interval of the Ct value of the <i>RdRp</i> gene according to the COVID-19 vaccination status (B) Least squares mean and 95% confidence in... by Jieun Jang (5245817)

50 year-old man with adenovirus type 55 pneumonia. by Dingyu Tan (3180789)

“…<p>(A), Initial CT scan obtained at the level of tracheal bifurcation on day 5 after the onset of illness shows focal consolidation in the left lower lung. …”

Scheme of putative signaling pathways involved in cytokine production induced by BbC50sn, LPS or Zymosan in DCs. by Cyrille Hoarau (94188)

“…<p>PI3K decreased IL-12 and increased IL-10 production with BbC50sn and Zymosan through (1) phosphorylation of Akt which inhibits GSK3 (inhibitor of CREB = IL-10 nuclear factor); (2) phosphorylation of ERK which positively regulates IL-10 in contrast to IL-12 production; (3) phosphorylation of p38MAPK which positively regulates IL-10 and IL-12 productions. …”

Breakdown of local information processing may underlie isoflurane anesthesia effects by Patricia Wollstadt (605354)

“…Information transfer between V1 and PFC was reduced bidirectionally, but with a stronger decrease from PFC to V1. …”

A cluster-randomized crossover trial of organic diet impact on biomarkers of exposure to pesticides and biomarkers of oxidative stress/inflammation in primary school children by Konstantinos C. Makris (684176)

Data_Sheet_1_Iron metabolism mediates the relationship between Vitamin C and hepatic steatosis and fibrosis in NAFLD.docx by Zhengyu Hu (290424)

“…Logistic regression and RCS models were used to analyze the correlations. In vitro study in hepG2 were conducted to validate the regulations. Ferritin increased while Vit C decreased with more severe hepatic steatosis and hepatic fibrosis (all P < 0.001). …”

DTG 3TC HIV EPI study.xlsx by Anna Esman (17983927)

“…Specifically, <i>CCR5</i> CpG 1 showed a significant increase in methylation from Week 0 to Week 48, while <i>CXCR4</i> CpG 3 displayed a significant decrease between Week 0 and Week 24. …”

List of proteins belonging to cell envelope stress response pathways whose level changes upon LptC depletion. by Alessandra M. Martorana (589438)

Image_5_Elucidating the changes in the heterogeneity and function of radiation-induced cardiac macrophages using single-cell RNA sequencing.tif by Chunxiang Cao (451327)

“…Then, we identified 7 clusters of macrophages by single-cell RNA sequencing and found two kinds of stage specific macrophages: senescence-associated macrophage (Cdkn1a^highC5ar1^high) on Day 7 and interferon-associated macrophage (Ccr2^highIsg15^high) on Day 35. …”

Data_Sheet_1_Conformational Change of Tetratricopeptide Repeats Region Triggers Activation of Phytochrome-Associated Protein Phosphatase 5.PDF by Silke von Horsten (11561332)

“…Molecular dynamics analyses of PAPP5 complexed to a phyB phosphopeptide show that this C-terminal motif remains associated with the TPR region in the substrate bound state, suggesting that this motif merely serves for restricting the orientations of the TPR region relative to the catalytic PP2A domain. …”

Video_1_Conformational Change of Tetratricopeptide Repeats Region Triggers Activation of Phytochrome-Associated Protein Phosphatase 5.MP4 by Silke von Horsten (11561332)

“…Molecular dynamics analyses of PAPP5 complexed to a phyB phosphopeptide show that this C-terminal motif remains associated with the TPR region in the substrate bound state, suggesting that this motif merely serves for restricting the orientations of the TPR region relative to the catalytic PP2A domain. …”

Indices derived from structural food web theory (A–B) and from thermodynamic and information theory (C–F). by Alice Boit (528321)

“…(F) Total exergy (<i>Ex</i> in g detritus equivalents/m², cf. Methods) and specific exergy (<i>Ex_sp</i> in units of <i>Ex</i> per unit of biomass in gC/m²) peaked during the CWP due to the high biomass of herbivorous crustaceans.…”

Dynamics of Th17 Cells and Their Role in <em>Schistosoma japonicum</em> Infection in C57BL/6 Mice by Xiaoyun Wen (186951)

The C₇H₆ Potential Energy Surface Revisited: Relative Energies and IR Assignment by Stephan Matzinger (2538523)

“…In analogy to the case of cyclopentadienylidene, <b>CHT</b> exists in the form of a closed shell singlet (¹A₁) and two related pairs of open shell singlet and triplet states (^1,3A₂ and ^1,3B₁) which correspond to the Jahn−Teller distorted structures of the cycloheptatrienyl radical. …”

Proportion of cytoplasm-carrying vesicles affects the DNA content carried by ExPEC EVs. by Min Jiang (56794)

Clusters of genes significantly modulated by valsartan treatment after myocardial infarction. by Laura Castiglioni (314248)

“…(<b><i>B</i></b>) Heatmap and (<b><i>D</i></b>) mean expression pattern of cluster 2, <i>i</i>.<i>e</i>. genes that were decreased in MI <i>vs</i>. sham group and up-regulated in MI+Val <i>vs</i>. …”

Aerobic lipid metabolism is required for DAF-12 to promote reproductive growth in <i>C</i>. <i>elegans</i>. by Zhu Wang (73828)

“…<p>(A) Inhibition of fatty acid oxidation by etomoxir delays the onsets of egg laying in <i>din-1;daf-9</i> mutants (n = 4), and (B–D) decreases DA-induced reproductive growth in <i>daf-7(e1372)</i>, <i>daf-9(dh6)</i>, and <i>daf-2(e1368)</i> mutants (n = 3). …”

Apoptosis-related proteins, AIF and Cyt C expression was detected by Western blot analysis after I/R injury. by Haibin Wang (219428)

“…In the I/R group, the levels of AIF and Cyt C increased significantly. However, pretreatment with propofol decreased the expression of AIF and Cyt C. …”