Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver. by Nicole K. Polinski (10947787)

“…<p>(A-B) GCase, (C-D) gluocosylceramide (GlcCer), and (E-F) glucosylsphingosine (GlcSph) levels measured in whole brain homogenate and liver homogenate of C57Bl/6 wild type (WT) and <i>GBA1</i> D409V KI heterozygous (HET) mice at 5 months of age (n = 10/age). …”

GIRK channels stabilize RMP of NPY neurons. by Youjin Oh (3308670)

Means and variability of spatiotemporal parameters of the MCI and control groups during SF and FS conditions. by Sirinun Boripuntakul (13994171)

Subjects:

Pre-treatment of IOZCAS-Spex-II cells with CPT and HCPT decreased Topo1 specific activity in a time-dependent manner. by Lan Zhang (90951)

Pre-treatment of IOZCAS-Spex-II cells with CPT and HCPT decreased Topo1 specific activity in a dose-dependent manner. by Lan Zhang (90951)

PKCε activation induces aggrecan gene expression, decreases ADAMTS5, and detection of ADAMTS-5-depended cleavage of ECM aggrecan through upregulation of hsa-miR-377 expression. by Emmanouella Tsirimonaki (490707)

“…<p>(<b>A</b>) RT-PCR detected the relative expression of ACAN, MKI67, ADAMTS5 after treatment of NP cells with 1 μM ψεRACK (or vehicle) for indicated times and revealed that time-dependent activation of PKCε significantly increased the mRNA expression for aggrecan, while in an opposing manner decreased ADAMTS5; mRNA levels of the proliferation marker Ki67 became barely detectable after 8 hours of PKCε activation. …”

C-terminal tagging of NCAPH2 can either increase or decrease protein expression. by Gillian C. A. Taylor (3909568)

Epistasis among SAUR63 and PP2C.D5 lines, and phenotypes related to PM H⁺-ATPase activity. by Punita Nagpal (185838)

Subjects:

Mutations at S1/S2 site reduce SARS-CoV-2 S cleavage. by Prerna Arora (821926)

The methodological figure of the experimental steps. by Railson de Oliveira Ferreira (6493700)

Chow-fed <i>Mecp2</i> KO mice have significantly increased WAT mass and serum leptin, and decreased rotarod performance. by Min Jung Park (642131)

Oxidation of glycans results in a decreased production of IL-4 and IL-10 and an increase of IFNγ by parasite specific splenocytes. by Ernesto Rodríguez (840670)

Fig 5 - by Dalia Zaafar (6693017)

Repeated dosing of P2Y13R agonist decreases HDL-C. by Marine Goffinet (90787)

Decreased 5-hmC expression was associated with <i>TET2</i> downregulation. by Xuejiao Shi (1684186)

Knockdown of JMJD2B decreased expression of PPARγ and C/EBPα. by Min-Kyung Jang (3111393)

Knockdown of NRP1 increases while knockdown of NRP2 decreases formation of Schwann cell clusters. by Kasper C. D. Roet (444802)

“…<p>(A–C) Representative SC clusters when co-cultured with MCs for 5 days after a transfection with siGlo, siNRP1 pool or siNRP2 pool respectively. …”

Transmission electron micrographs of step 5 spermatids. by Yonggang Lu (358237)

“…<p><b>(A)</b> As the nuclear size (N) of step 5 spermatids decreases, the decondensed chromosomes are aggregated into a retiform pattern. …”

MeV disrupted mitochondrial network and cellular metabolism. by Pierre Khalfi (7868252)

Subjects:

Oral UOX decreased SUA (A), BUN (B) and Cr (C) (mean ± SD, n = 10). by Yu Yun (4710340)