Low apolipoprotein A-I levels in Friedreich’s ataxia and in frataxin-deficient cells: Implications for therapy by QingQing Wang (1389630)

“…One also showed that there was no difference in serum Apo-A-I levels in FA when compared with controls. Using a highly specific stable isotope dilution mass spectrometry-based assay, we demonstrated a 21.6% decrease in serum ApoA-I in FA patients (134.8 mg/dL, n = 95) compared with non-affected controls (172.1 mg/dL, n = 95). …”

Intermittent Heat Shocks Can Reduce Methanogenesis and Increase Generation of Longer-Chain Volatile Fatty Acids in Anaerobic Bioreactors by Hezhou Ding (14242293)

“…The relative abundances of putative chain-elongating bacteria increased and those of syntrophic acetate-forming bacteria decreased when the HSs were applied. Our findings show that intermittent HSs may provide a chemical-free methanogen-specific strategy to improve the production of VFAs, especially longer-chain species.…”

Histological findings. by Daniel Mathias (709246)

Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase by Fanny Ender (3775861)

“…Finally, neither CD103⁺ cDCs nor cells of the lymphoid lineage such as Th2 or Th17-differentiated CD4⁺ T cells, B cells or type 2 innate lymphoid cells (ILC2) expressed C5aR1 under allergic conditions. …”

Immunohistochemical labeling for thrombospondin 1. by Harry A. Quigley (695817)

Data_Sheet_1_Case Report: Exome Sequencing Identified a Novel Compound Heterozygous Variation in PLOD2 Causing Bruck Syndrome Type 2.XLS by Jing Zhang (23775)

“…Prenatal genetic testing with whole-exome sequencing (WES) identified a compound heterozygous variation in the PLOD2 gene with two variants, namely c.2038C>T (p.R680^*) and c.191_201+3 delATACTGTGAAGGTA (p.Y64Cfs^*12). …”

Durable Nanocellulose-Stabilized Emulsions of Dithizone/Chloroform in Water for Hg²⁺ Detection: A Novel Approach for a Classical Problem by Roberto J. Aguado (14671561)

Durable Nanocellulose-Stabilized Emulsions of Dithizone/Chloroform in Water for Hg²⁺ Detection: A Novel Approach for a Classical Problem by Roberto J. Aguado (14671561)

ORF63 does not affect STAT2 activation but promotes IRF9-degradation. by Marieke C. Verweij (357813)

“…(D) TRFs were infected with AdORF63 at MOI 20 and AdTA at MOI 10 and incubated with decreasing amounts of Dox. 48 hours p.i. the cells were lysed and stained for STAT1, STAT2, ORF63 and GAPDH. …”

The mean number of gridlines crossed (a) and the mean number of times animals were observed using refuge (b) in 30 seconds for <i>Rana aurora</i> (a,b) and <i>Anaxyrus boreas</i> (... by Barbara A. Han (294479)

Motor neuron numbers are decreased in respiratory motor nuclei (hypoglossal, phrenic) and increased in forelimb innervating motor nuclei (brachial) in GAD67-deficient mice (−/−) co... by Matthew J. Fogarty (283288)

Antibodies. by Daniel Mathias (709246)

Recognition of Double Strand Breaks by a Mutator Protein (MU2) in <em>Drosophila melanogaster</em> by Raghuvar Dronamraju (204100)

“…Domain searches indicated that the protein contains an N-terminal FHA domain and a C-terminal tandem BRCT domain. Peptide pull-down studies showed that the BRCT domain interacts with phosphorylated H2Av, while the FHA domain interacts with the complex of MRE11, RAD50, and NBS. …”

Samples. by Daniel Mathias (709246)

Table_2_Case Report: A Novel Mutation in NFKB1 Associated With Pyoderma Gangrenosum.DOCX by Ran Fang (533948)

“…The functional analysis showed that the variant caused reduced phosphorylation of p105 and resulted in the decreased processing of p105 to p50. We conclude that the patient's symptoms were caused by dysregulation of the NF-κB signaling pathway.…”

Serum CTX and PINP on Days 2 and 59 of the 8-week exercise x mineral-supplemented diet experiment. by Michael A. Friedman (2578648)

“…*Significant exercise effect on day 2 (*p < 0.05, ***p < 0.001, Two-way ANOVA). ^Significant interactive effect of diet and exercise on day 2 (p < 0.05, Two-way ANOVA). …”

Pattern of ATPα immunoreactivity in <i>cry⁰¹</i> mutants under LD (A) and DD (B) and in rescue flies under LD (C). by Milena Damulewicz (349123)

“…The immunoreactivity of the α subunit was highest at ZT16 and decreased at other time points (ZT13 by 16%, ZT1 by 50.08%, and ZT4 by 56.4%). …”

Differentially expressed α-linoleic acid and arachidonic acid metabolism genes in Slfn3KO mice. by Emilie E. Vomhof-DeKrey (6900677)

siRNA mediated knockdown of NBS1 decreased the levels of phosphorylated Akt (pAkt Ser-473) and its downstream targets and IR increased the levels of NBS1 and phosphorylated Akt. by Jian-Qiu Wang (419143)

“…</b> Western blot analysis showed that knockdown of NBS1 decreased the phosphorylated levels of Akt, GSK-3β, and Foxo1/3a). …”

Impaired bone formation in <i>Col1a1-Krm2</i> transgenic mice. by Jochen Schulze (365258)

“…(B) Histomorphometric quantification showing that the number of osteoblasts (ObN/BPm, osteoblast number per bone perimeter) is not significantly decreased in sections from transgenic mice. (C) Fluorescent micrographs showing that overall calcein labeling is reduced in vertebral bodies of 6 weeks old female <i>Col1a1-Krm2</i> transgenic mice (top, scale bars, 1 mm), as is the distance between the labeled surfaces at endosteal bone surfaces of the tibia (bottom, scale bars, 20 µm). …”