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GluN2A(D731N) decreases current amplitudes and shortens synaptic-like response time course.
Published 2017Subjects: -
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Decreased projections to LP in <i>Brn3b</i> mutants occur postnatally.
Published 2023“…(<b>H</b>) Quantification (1.00 ± 0.09 for control, 0.45 ± 0.03 for cKO); unpaired two-tailed Student’s <i>t</i> test (mean ± SEM; <i>p</i> < 0.0001 [****] at P4/P5; <i>p</i> = 0.0004 [***] at P8/P9; <i>p</i> = 0.0012 [**] at P12/P13). …”
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DTG mice have significantly decreased troponin I phosphorylation and Serca2 expression.
Published 2013“…<p>(A) Representative Western blots depicting no changes in the expression of phosphorylated protein kinase A (P-PKA) and decreased expression of phosphorylated troponin I (P-TnI) and Serca2. ß-tubulin was used as a loading control. …”
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GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age.
Published 2021“…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”
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Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver.
Published 2021“…(A-B) GCase levels as assessed by the CBE/4-MU method are significantly decreased in the het <i>GBA1</i> D409V KI mice at 5 months of age in both brain (A) and liver (B). …”
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AS021 activity and Satb2 expression decrease within deep layers at postnatal stages.
Published 2011“…(E–G″′) Immunostaining for Satb2 (red), Ctip2 (blue), and βgal (green) in coronal sections of P2 AS021-lacZ brains reveals a strong decrease of Satb2 staining specifically in deep layers. …”