Repeated dosing of P2Y13R agonist decreases HDL-C. by Marine Goffinet (90787)

Activated CD4+ CD45RO+ memory T-cells decrease secretion of soluble caspase-1 and P2X7R mRNA expression in monocytes leading to a reduced response upon ATP binding. by Vanessa Beynon (153924)

“…A significant decrease of soluble Caspase-1 in the supernatant of cells co-cultured with activated memory T-cells was observed both in the presence and absence of IFNβ; b) intracellular levels of pro-IL-1β measured with an ELISA specific for the immature precursor of IL-1β showed a significant increase in pro-IL-1β levels in the presence of human activated CD4+CD45RO+ memory T-cells (n = 3), cell lysates from adherent monocytes were obtained after removal of non-adherent T-cells after addition of LPS and prior to incubation with ATP c) the ratio of intracellular pro-IL-1β to released soluble Caspase-1 is significantly increased in the presence of human activated CD4+CD45RO+ memory T-cells (n = 3). d) <i>P2X7R</i> mRNA expression in monocytes cultured overnight with activated CD4+CD45RO+ memory T-cells is decreased with and without addition of exogenous IFNβ (n = 3), mRNA was isolated from adherent monocytes after removal of non-adherent T-cells after addition of LPS and prior to incubation with ATP (Data are shown as means ± SD of duplicate cultures; *p<0.05; **p<0.01 employing repeated measures ANOVA with post-hoc Bonferroni adjustment for multiple comparisons to avoid random correlations); e) Ca²⁺-influx measurement in monocytes cultured with activated human CD4+CD45RO+ memory T-cells in the presence of IFNβ demonstrates the absence of slow sustained Ca²⁺-influx mediated by ATP binding to the purinergic P2X7-receptor (representative of 3 independent experiments); f) Annexin V staining of monocytes coincubated with T-cells and stimulated with LPS was measured by flow cytometry (representative flow cytometry histogram of n = 5).…”

Disruption of FGFR1-Frs2/3 pathway decreases the number of support cells. by Kazuya Ono (513633)

PTB is associated with decreased spontaneous production of Type 1, 2, 17 and immunoregulatory cytokines. by Nathella Pavan Kumar (129299)

Prolonged Htr2b activation decreases ATP content and coupled mitochondrial respiration in MIN6. by Luis Rodrigo Cataldo (3701206)

All data points from Fig 2. by Sara Hijazi (21656615)

“…Following a remyelination period of 5 weeks, PV interneuron properties were only partially recovered, suggesting that transient juvenile demyelination leads to long-lasting impairments of PV interneuron function. …”

All data points from Fig 8. by Sara Hijazi (21656615)

“…Following a remyelination period of 5 weeks, PV interneuron properties were only partially recovered, suggesting that transient juvenile demyelination leads to long-lasting impairments of PV interneuron function. …”

All data points from Fig 3. by Sara Hijazi (21656615)

“…Following a remyelination period of 5 weeks, PV interneuron properties were only partially recovered, suggesting that transient juvenile demyelination leads to long-lasting impairments of PV interneuron function. …”

All data points from Fig 1. by Sara Hijazi (21656615)

“…Following a remyelination period of 5 weeks, PV interneuron properties were only partially recovered, suggesting that transient juvenile demyelination leads to long-lasting impairments of PV interneuron function. …”

All data points from Fig 4. by Sara Hijazi (21656615)

“…Following a remyelination period of 5 weeks, PV interneuron properties were only partially recovered, suggesting that transient juvenile demyelination leads to long-lasting impairments of PV interneuron function. …”

All data points from Fig 9. by Sara Hijazi (21656615)

“…Following a remyelination period of 5 weeks, PV interneuron properties were only partially recovered, suggesting that transient juvenile demyelination leads to long-lasting impairments of PV interneuron function. …”

All data points from Fig 7. by Sara Hijazi (21656615)

“…Following a remyelination period of 5 weeks, PV interneuron properties were only partially recovered, suggesting that transient juvenile demyelination leads to long-lasting impairments of PV interneuron function. …”

All data points from Fig 6. by Sara Hijazi (21656615)

“…Following a remyelination period of 5 weeks, PV interneuron properties were only partially recovered, suggesting that transient juvenile demyelination leads to long-lasting impairments of PV interneuron function. …”

The involvement of ERK5 in statin-induced Nrf2 signaling in VSMCs. by Ae-Rang Hwang (4040408)

Subjects:

High glucose-containing media decreases mitochondrial membrane potential and ATP levels of in mixed glia cultures. by Yung-Cheng Huang (3443450)

Subjects:

(Related to Fig 5B and 5C). Comparison of mean percentages of transfected cells with SGs calculated from three biological triplicates, showing the decrease in % as compared to wt N or the mutant N1a+N2b N. by Chiara Aloise (8374950)

Descriptives of the study sample, N = 451. by Orrin D. Ware (14829115)

Mutations at S1/S2 site reduce SARS-CoV-2 S cleavage. by Prerna Arora (821926)

Treatment with vitamin D3 reduced the viability of cancer cell lines: <i>1A & 1B.</i> by Vidya G. Bettada (22208808)

“…<p>Human keratinocyte cell line HaCaT and human lung epithelial cell line BEAS-2B did not respond to vitamin D3 treatment. Very minimal cytotoxic effect (<10% cell death) was observed at the highest concentration of vitamin D3 tested (i.e., 400µM). 1C. …”

Δ<i>ptsI</i> mutants are impaired for intramacrophage growth and virulence, with more decreased virulence in a Δ<i>glpD</i>/Δ<i>golD</i>/Δ<i>uhpT</i> background and can be trans-co... by Matthew J. Freeman (21094788)