Decreased circulating follicular regulatory T cells in patients with dilated cardiomyopathy by Xixi Liu (1716049)

Effect of fenfluramine and sodium valproate on hyperthermia-induced abnormalities on 5 dpf-ATG MO- and CTRL MO-injected larvae. by Yifan Zhang (119570)

“…Error bars on all graphs represent the standard error of mean (SEM). ** P ≤ 0.01.</p>…”

Characterization of Growth Suppressive Functions of a Splice Variant of Cyclin D2 by Karim Wafa (103731)

“…<div><p>We have recently cloned a novel splice variant of cyclin D2 termed as cycD2SV. CycD2SV overexpression in several immortalized cell lines led to formation of ubiquitinated protein aggregates accompanied by a significant decrease in cell proliferation. …”

Metronidazole thermogel improves retention and decreases permeation through the skin by Elayne Karine Souto de Melo (12848144)

Speed of misspecified cells decreases with magnitude of differential adhesion, j by Keng-hwee Chiam (623069)

Aggressive blood pressure reduction is not associated with decreased perfusion in leukoaraiosis regions in acute intracerebral hemorrhage patients - Fig 1 by Mahesh Kate (4037570)

2‑(Fluoromethoxy)-4′‑(<i>S</i>‑methanesulfonimidoyl)-1,1′-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D₁ Receptor for... by Javier García-Cárceles (2073898)

“…In search for selective modulators of the D₁ receptor, the screening of a chemical library and subsequent medicinal chemistry program around an identified hit resulted in new synthetic compound <b>26</b> [UCM-1306, 2-(fluoromethoxy)-4′-(<i>S</i>-methanesulfonimidoyl)-1,1′-biphenyl] that increases the dopamine maximal effect in a dose-dependent manner in human and mouse D₁ receptors, is inactive in the absence of dopamine, modulates dopamine affinity for the receptor, exhibits subtype selectivity, and displays low binding competition with orthosteric ligands. …”

2‑(Fluoromethoxy)-4′‑(<i>S</i>‑methanesulfonimidoyl)-1,1′-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D₁ Receptor for... by Javier García-Cárceles (2073898)

“…In search for selective modulators of the D₁ receptor, the screening of a chemical library and subsequent medicinal chemistry program around an identified hit resulted in new synthetic compound <b>26</b> [UCM-1306, 2-(fluoromethoxy)-4′-(<i>S</i>-methanesulfonimidoyl)-1,1′-biphenyl] that increases the dopamine maximal effect in a dose-dependent manner in human and mouse D₁ receptors, is inactive in the absence of dopamine, modulates dopamine affinity for the receptor, exhibits subtype selectivity, and displays low binding competition with orthosteric ligands. …”

2‑(Fluoromethoxy)-4′‑(<i>S</i>‑methanesulfonimidoyl)-1,1′-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D₁ Receptor for... by Javier García-Cárceles (2073898)

“…In search for selective modulators of the D₁ receptor, the screening of a chemical library and subsequent medicinal chemistry program around an identified hit resulted in new synthetic compound <b>26</b> [UCM-1306, 2-(fluoromethoxy)-4′-(<i>S</i>-methanesulfonimidoyl)-1,1′-biphenyl] that increases the dopamine maximal effect in a dose-dependent manner in human and mouse D₁ receptors, is inactive in the absence of dopamine, modulates dopamine affinity for the receptor, exhibits subtype selectivity, and displays low binding competition with orthosteric ligands. …”

2‑(Fluoromethoxy)-4′‑(<i>S</i>‑methanesulfonimidoyl)-1,1′-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D₁ Receptor for... by Javier García-Cárceles (2073898)

“…In search for selective modulators of the D₁ receptor, the screening of a chemical library and subsequent medicinal chemistry program around an identified hit resulted in new synthetic compound <b>26</b> [UCM-1306, 2-(fluoromethoxy)-4′-(<i>S</i>-methanesulfonimidoyl)-1,1′-biphenyl] that increases the dopamine maximal effect in a dose-dependent manner in human and mouse D₁ receptors, is inactive in the absence of dopamine, modulates dopamine affinity for the receptor, exhibits subtype selectivity, and displays low binding competition with orthosteric ligands. …”

2‑(Fluoromethoxy)-4′‑(<i>S</i>‑methanesulfonimidoyl)-1,1′-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D₁ Receptor for... by Javier García-Cárceles (2073898)

“…In search for selective modulators of the D₁ receptor, the screening of a chemical library and subsequent medicinal chemistry program around an identified hit resulted in new synthetic compound <b>26</b> [UCM-1306, 2-(fluoromethoxy)-4′-(<i>S</i>-methanesulfonimidoyl)-1,1′-biphenyl] that increases the dopamine maximal effect in a dose-dependent manner in human and mouse D₁ receptors, is inactive in the absence of dopamine, modulates dopamine affinity for the receptor, exhibits subtype selectivity, and displays low binding competition with orthosteric ligands. …”

Target specificity, <i>in vivo</i> pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma by Peter Y. Yu (4281448)

“…The purpose of this work was to develop and test a novel putative STAT3 inhibitor, LY5.</p><p>Methods and findings</p><p>An <i>in silico</i> fragment-based drug design strategy was used to create LY5, a small molecule inhibitor that blocks the STAT3 SH2 domain phosphotyrosine binding site, inhibiting homodimerization. …”

The Rho⁺ strain exhibits sporulation-negative phenotype. by Vladimir Bidnenko (4258573)

LY5 inhibits STAT3 phosphorylation in lung metastases but does not inhibit lung metastasis formation. by Peter Y. Yu (4281448)

Rat tickling: A systematic review of applications, outcomes, and moderators by Megan R. LaFollette (3911140)

“…The most common method used for tickling was cycling through 15 seconds of tickling and 15 seconds of rest for 2 minutes for 3 to 5 days. Experiments with a control for tickling (N = 22) showed that tickling increases positive vocalization, approach behavior, decreases anxiety measures, improves handling, and in some cases decreases stress hormones. …”

The relationship of serum vitamins A, D, E and LL-37 levels with allergic status, tonsillar virus detection and immune response - Fig 2 by Varpu Elenius (114547)

“…Rhinovirus (RV), bocavirus-1 (BoV), adenovirus (AdV), enteroviruses (EV), coronavirus (CV), parainfluenza virus types 1–4 (PIV), metapneumovirus (MPV), influenza A or B virus (Flu), respiratory syncytial virus (RSV). …”

Table_1_NASAFYTOL® supplementation in adults hospitalized with COVID-19 infection: results from an exploratory open-label randomized controlled trial.DOCX by Jean Gérain (16415511)

“…The clinical condition of participants in the Nasafytol^® arm had improved, as evidenced by a decrease in the COVID-19 WHO score. Interestingly, five SAEs occurred with Fultium^®, while no SAE was observed with Nasafytol^®.…”

Sociodemographic characteristics of participants (n = 1482). by Leila Cheikh Ismail (3152526)

Subjects:

The frequency of consumption of foods among participants (n = 1482). by Leila Cheikh Ismail (3152526)

Subjects:

Lifestyle characteristics of participants (n = 1482). by Leila Cheikh Ismail (3152526)

Subjects: