Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Percentage of biomass that decreased in relation to the control after the incubation period (5 days) of the experimental cultures containing 100 ml of each of the three different <... by Fabiana Araújo (5052323)

Inhibition of Cl^- channels decreases CHIKV replication. by Marietta Müller (7345163)

“…The titer was determined at 12 hpi, (n ≥ 3). <b>D)</b> CHIKV was incubated with the compounds at 37°C (except for DEPC ≙ RT) for 1 hr prior to adsorption to Huh7 cells (MOI 2). …”

Bromodomain inhibition decreases virulence in a mouse model of infection. by Danae Schulz (230393)

Differential expression of the AbrB, ComK, CodY and stringent response regulons in the Rho⁺ strain across exponential growth and stationary phase. by Vladimir Bidnenko (4258573)

PGRN deficiency results in decreased GCase activity in mouse tissues. by Xiaolai Zhou (3547520)

Inhibition of PDK1 induces apoptosis and decreases cell motility. by Swatishree Sradhanjali (4025933)

Renal blood flow is decreased during pneumoperitoneum compared to baseline. by Kimberley E. Wever (180536)

Decreased GPIHBP1 protein levels in visceral adipose tissue partly underlie the hypertriglyceridemic phenotype in insulin resistance by R. Preethi Surendran (5946038)

Rapamycin decreases phosphorylation of downstream targets of mTOR in the skin. by Lydia Jiménez-Díaz (44306)

“…</i> White arrows indicate double-labelled fibers. Note the overall decrease of phospho-S6K labelling after rapamycin injection. ep, epidermis; d, dermis. …”

Omeprazole (Ome) decreases IL-4-stimulated RNA Pol II binding to the endogenous eotaxin-3 promoter in (A) EoE1-T and (B) EoE2-T cells. by Xi Zhang (83736)

Prion infection decreases sortilin in a cell-autonomous way. by Keiji Uchiyama (140599)

() Increase and decrease of fly gene transcript levels during embryogenesis by Sean D Hooper (55379)

Knockdown of endogenous DJ-1 leads to decreased DA reuptake. by Beryl Luk (787284)

“…(B) The levels of DJ-1 expression was quantified to show significant knockdown of DJ-1 levels in cells transfected with siDJ-1#1 and siDJ-1#3 (50–60% decrease compared to controls), while siDJ-1#2 exhibited a decreasing trend in DJ-1 expression. * P<0.05 vs control group; one-way ANOVA post hoc Tukey test, n = 3. …”

Decreased detection threshold after training suggests perceptual learning. by Sarah M. Bernhard (9721005)

Decrease in ATP and AMPK activation in sensitive and resistant cell lines. by Alper Y. Kearney (789031)

α-diversity pre- and post-SG-surgery. by Manal Ali Ahmad (16868808)

FTY720 decreased the γ-secretase-mediated cleavage of APP. by Nobumasa Takasugi (410919)