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221
Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis-2
Published 2011“…Nized and BAL cells (A, B), freshly isolated type II alveolar epithelial cells (A, C), lung homogenate (A, D), and concentrated BAL fluid supernatant (E) were prepared for analysis of cath K mRNA by real-time RT-PCR (A) and western blotting (B-E). …”
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PPP2R5C HepKD in <i>db/db</i> mouse liver improves insulin sensitivity, decreases hyperglycemia, but worsens the dyslipidemia.
Published 2015“…<p><b>(A)</b> Hyperglycemia in <i>db/db</i> mice is decreased upon hypatocyte-specific PPP2R5C knockdown with adeno-associated virus. …”
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Decrease of ECT2 phosphorylation at T359 residue in DLC1 overexpressing cells.
Published 2018“…<p><b>A.</b> Significant decrease in two phosphopeptides (ANTPELK) and (ANTPELKK, with one missed cleavage) in DLC1-FL overexpressing cells compared to control vector cells (FDR-corrected <i>p</i>-value < 0.1). …”
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Spatial stability is decreased in APP/PS1 mice in both dCA1 and vCA1.
Published 2024“…<p>(A) In dCA1, stability score was significantly decreased in APP/PS1 mice relative to C57BL/6 mice (mean ± std: C57BL/6 = -0.009 ± 0.292, APP/PS1 = -0.1845 ± 0.256, p < 10<sup>−6</sup>, two-sided Wilcoxon rank-sum test, n<sub>C57BL/6</sub> = 295 units from 5 recording sessions, n<sub>APP/PS1</sub> = 167 units from 4 recording sessions). …”
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Spatial information is significantly decreased in dCA1 and vCA1 in APP/PS1 mice.
Published 2024“…Histograms show the mean firing rate for the corresponding neuron along each segment of the virtual track. (B) In dCA1, spatial information was decreased in APP/PS1 mice relative to C57BL/6 controls (mean ± std: C57BL/6 = 0.132 ± 0.048, APP/PS1 = 0.128 ± 0.051, p < 0.005, two-sided Wilcoxon rank-sum test, n<sub>C57BL/6</sub> = 305 units from 5 recording sessions, n<sub>APP/PS1</sub> = 180 units from 4 recording sessions). …”
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HERVK HML-2 <i>env</i> knockdown decreases IFN-I expression and alters the secretory profile of THP1 monocytes and primary MDMs.
Published 2021“…<p>(<b>A</b>) Transcription of HERVK HML-2 and five other HERV clades, identified upregulated by RNA-Seq in both irradiated THP1 cells and MDMs (<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1009305#ppat.1009305.g004" target="_blank">Fig 4A</a>), measured by RT-qPCR in THP1 cells expressing control (grey) or shRNA-Env (red), 48h post-irradiation. …”