Disrupting the association between B-MYB and YAP by MY-COMP. by Marco Gründl (8911844)

“…C) Pulldown experiments with GST-WW and his-tagged B-MYB(2–241) and B-MYB(2–241,ΔPPXY). Bound B-MYB was detected with a his-antibody. …”

The non-diuretic hypotensive effects of thiazides are enhanced during volume depletion states by Saeed Alshahrani (3148368)

“…HCTZ (20mg/kg s.c.) lowered BP in 1) NCC KO on a salt restricted diet but not with normal diet; 2) in volume depleted but not in volume resuscitated pendrin/NCC dKO mice; the BP reduction occurs without any enhancement in salt excretion or reduction in cardiac output. …”

DataSheet1_Integrated Metabolomics and Network Pharmacology to Establish the Action Mechanism of Qingrekasen Granule for Treating Nephrotic Syndrome.docx by Yanfen Duan (11795333)

“…Moreover, the expression levels of p-PI3K, p-AKT1, p-mTOR, and CASP3 in the QRKSG group significantly decreased, while BCL2L1 increased compared to the model group. …”

Pathways involved in clearance of pneumococcal colonization. by Kirsten Kuipers (5917496)

“…RNA-seq heatmaps show gene expression of the comparison wild-type colonized versus mock controls with relative gene expression in log2 fold change demonstrating increased expression in red and decreased expression in blue. …”

Data_Sheet_1_Excess DHA Induces Cell Cycle Arrest by Activating the P53/Cycling Pathway in Blunt Snout Bream (Megalobrama amblycephala).pdf by Cong-cong Wang (8847275)

“…The results showed that the final body weight and weight gain of fish fed 1.6% DHA were significantly lower than those of fish fed 0.2% DHA (P < 0.05). P53 gene and protein expression levels were significantly increased (P < 0.05), while expression of downstream Cyclin D1 and Cyclin E1 was significantly inhibited in the 1.6% DHA group when compared with the 0 and 0.2% DHA groups (P < 0.05). …”

Image3_Integrated Metabolomics and Network Pharmacology to Establish the Action Mechanism of Qingrekasen Granule for Treating Nephrotic Syndrome.TIF by Yanfen Duan (11795333)

“…Moreover, the expression levels of p-PI3K, p-AKT1, p-mTOR, and CASP3 in the QRKSG group significantly decreased, while BCL2L1 increased compared to the model group. …”

DataSheet_1_Metabolic Profiling Analysis of Patients With Coronary Heart Disease Undergoing Xuefu Zhuyu Decoction Treatment.doc by Tianqi Tao (7361189)

“…Among the six differential metabolites, FA (20:2)-H and tetracarboxylic acid (24:0), involved in fatty acid metabolism; cis-aconitic acid, which participates in the tricarboxylic acid cycle; 2-deoxy-D-glucose, involved in glucose metabolism; and N-acetylglycine, involved in amino acid metabolism, were decreased, whereas spermine, which participates in amino acid metabolism, was increased as compared with the placebo group. …”

Image1_Integrated Metabolomics and Network Pharmacology to Establish the Action Mechanism of Qingrekasen Granule for Treating Nephrotic Syndrome.TIF by Yanfen Duan (11795333)

“…Moreover, the expression levels of p-PI3K, p-AKT1, p-mTOR, and CASP3 in the QRKSG group significantly decreased, while BCL2L1 increased compared to the model group. …”

Inclusion of Opuntia stricta (Haw.) in sheep diets affects nutrition and the physicochemical characteristics of the rumen content by Cintia Mirely de Araujo (5834057)

“…<div><p>ABSTRACT The aim of this study was to evaluate the effects of the inclusion of the cactus Opuntia stricta (Haw.) in sheep diets on the feed intake, digestibility, fermentation, and physicochemical characteristics of the ruminal digesta. Five sheep cannulated in the rumen (61.5±9.5 kg body weight) were assigned in a Latin square design (5×5), with five diets and five experimental periods of 21 days each. …”

Antibiotic stewardship based on procalcitonin (PCT) cut-off ranges by Philipp Schuetz (33688)

“…In all patients with a very high PCT value on admission (e.g., >10 μg/L), discontinuation of antibiotic is already encouraged if levels decreased below 80 to 90% of the initial value. …”

mRNA quantification of <i>Helix pomatia CdMT</i> gene transcription after exposure to oxygen depletion through 24 hours. by Veronika Pedrini-Martha (694659)

“…<p><b>(A)</b> Plot of average oxygen concentration (%) in the atmosphere of the exposure chamber throughout the whole experiment, showing one oxygen peak due to sampling at 08:00 pm, when the oxygen level in the chamber rose up to 14% and decreased within 5 minutes under less than 1%. …”

Electron Transfer Studies on Ferrocenylthiophenes: Synthesis, Properties, and Electrochemistry by J. Matthäus Speck (1554352)

“…The ferrocenylthiophenes 2,3-Fc₂-^<i>c</i>C₄H₂S (<b>9</b>), 2,4-Fc₂-^<i>c</i>C₄H₂S (<b>10</b>), and 2,3,4-Fc₃-^<i>c</i>C₄HS (<b>11</b>) have been prepared by a 2- or 3-fold Negishi cross-coupling reaction of the appropriate bromo thiophenes <b>5</b>–<b>7</b> with FcZnCl (<b>8</b>; Fc = Fe­(η⁵-C₅H₄)­(η⁵-C₅H₅)) in the presence of either [Pd­(PPh₃)₄] or [Pd­(CH₂CMe₂P^<i>t</i>Bu₂)­(μ-Cl)]₂ as catalyst. …”

Variation in leg motion responses to different closed-loop control settings. by Feng Cao (38032)

“…In general, as the <i>K</i>_p value was increased from 0.5 to 1.5 and the update time interval <i>t</i> was decreased from 300 ms to 100 ms, (A) the leg response overshoot angle (absolute values used for all the motions) increased, whereas (B) the reaching-time decreased. …”

Trial time course. by Alexander Prehn-Kristensen (262650)

“…<p>In the beginning of each trial, participants were requested to exhale (a ball decreased in diameter for 3 s) and then to inhale (a ball increased in diameter for 3 s). …”

Evaluation of chemopreventive and chemotherapeutic effect of Artemisia vulgaris extract against diethylnitrosamine induced hepatocellular carcinogenesis in Balb C mice by S. Ali (6274937)

“…Mice were classified into four groups as follows: Group 1 a control group (N=7) received saline solution (3.5 μl/mg), group 2 (N=14) received diethylnitrosoamine (3.5 μl/mg) intraperitoneally once in a week for eight consecutive weeks, group 3 (N=7) received only plant extract (AV: 150 mg/kg (Body weight) once in a week, while group 4 (N=7) was given in combination of diethylnitrosoamine (3.5 μl/mg) and plant extract (AV: 150 mg/kg (body weight). …”

Evaluation of chemopreventive and chemotherapeutic effect of Artemisia vulgaris extract against diethylnitrosamine induced hepatocellular carcinogenesis in Balb C mice by S. Ali (6274937)

“…Mice were classified into four groups as follows: Group 1 a control group (N=7) received saline solution (3.5 μl/mg), group 2 (N=14) received diethylnitrosoamine (3.5 μl/mg) intraperitoneally once in a week for eight consecutive weeks, group 3 (N=7) received only plant extract (AV: 150 mg/kg (Body weight) once in a week, while group 4 (N=7) was given in combination of diethylnitrosoamine (3.5 μl/mg) and plant extract (AV: 150 mg/kg (body weight). …”

p53:MdmX and Mdm2:MdmX heterodimers act as reservoirs and generate switch-like dependence of p53. by Sohyoung Kim (253617)

“…The small white circle in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000665#pcbi-1000665-g005" target="_blank">Figure 5-B</a> corresponds to ΔA when k6 = 0.001 in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000665#pcbi-1000665-g005" target="_blank">Figure 5-A</a>. …”

CDKs phosphorylate Nbs1 on Ser432 in vitro and in vivo. by Lara Wohlbold (140240)

“…Histone H1, monomeric Cdk2, and the carboxyl-terminal domain (CTD) of RNA polymerase II, served as control substrates for Cdk1 or -2, Cdk7, and Cdk9, respectively. …”

Effect of DCA on cell viability, intracellular ROS levels and glucose metabolism in hepatoma cells after 48/L DCA. by Yunhai Dai (550841)

“…<p>(A) Cell viability was determined as described above. 20 mmol/L DCA treatment decreased viability of the 2 hepatoma cell lines but not the normal hepatocyte cell line LO₂. …”

Data_Sheet_1_Endotoxemia-Induced Release of Pro-inflammatory Mediators Are Associated With Increased Glomerular Filtration Rate in Humans in vivo.DOCX by Remi Beunders (9604286)

“…Mean arterial pressure decreased with 13 ± 11 mmHg (p < 0.0001). …”