Severe decreases of TECs and impaired TEC expansion in the absence of mTORC1/Raptor. by Hong-Xia Wang (288934)

“…The gating strategy is shown in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002370#pbio.1002370.s003" target="_blank">S2 Fig</a>. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Elevated IL-18, NF-κB p65, and YY1 expression and decreased FXR and MRP2 were observed in the BDL rats. by Xiao-cong Liu (785281)

SgG2 modifies NGF-TrkA signaling. by Jorge Rubén Cabrera (685511)

Global Land Use Change Impacts on Soil Nitrogen Availability and Environmental Losses by Jing Wang (6206297)

“…However, how global land use changes impact soil N supply and potential N loss remains elusive. By compiling a global data set of 1,782 paired observations from 185 publications, we show that land use conversion from natural to managed ecosystems significantly reduced NNM by 7.5% (−11.5, −2.8%) and increased NN by 150% (86, 194%), indicating decreasing N availability while increasing potential N loss through denitrification and nitrate leaching. …”

A SCA11-associated allele of <i>Ttbk2</i> interferes wild-type TTBK2 function in cilia formation. by Emily Bowie (543704)

CsA reduces Flk1 protein expression and significantly decreases the percentages of Flk1+ cells. by Seung-Cheol Choi (686982)

Regression Results for Average Antibiotic Resistance. by Peter Collignon (704972)

GIRK channels stabilize RMP of NPY neurons. by Youjin Oh (3308670)

Microarray analysis from GEO database showed TNFAIP9 was enhanced in CKD patients and mice. by Ying Chen (9697)

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Different Association of Human Papillomavirus 16 Variants with Early and Late Presentation of Cervical Cancer by Ana Alfaro (280118)

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Five genes involved in piRNA biosynthesis were commonly down-regulated in the two <i>enok</i> mutants as compared with the WT control, while the expression levels of <i>piwi</i>, <... by Shih-Ying Tsai (3576587)

Variable 5´ UTRs detected in the human YT cell line, peripheral blood NK, and spleen. by Hongchuan Li (375905)

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Impaired NKG2D expression on CD56+CD3+ lymphocytes correlates to decreased IFN-γ production. by Po-sung Chu (549427)

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RDV mixed array inhibitor screen with SARS-CoV-2_Engl2 in VeroE6 cells. by Agnieszka M. Szemiel (10196243)

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CD107a-, IFNγ- and MIP 1β-producing Vγ9Vδ2 T-cell subsets decrease in HIV+ patients. by Rita Casetti (608635)

An example of three consecutive accretive growth steps. by Nol Chindapol (103374)

Decreased intestinal TG accumulation and absence of fat malabsorption in <i>Ces1/Es-x^−/−</i> mice. by Ariel D. Quiroga (300200)

Inhibition of Cu²⁺-mediated of LDL oxidation by cannabis extracts. by Bruno Musetti (9527085)

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