The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis by Shulan Pi (8562315)

“…</p> <p><b>Abbreviations:</b> 2-MeSAMP: 2-methylthioadenosine 5′-monophosphate; 8-CPT-cAMP: 8-(4-chlorophenylthio)-adenosine-3ʹ,5ʹ-cyclic-monophosphate; ABCA1: ATP binding cassette subfamily A member 1; ABCG1: ATP binding cassette subfamily G member 1; ACTB: actin beta; ADPβs: adenosine 5′-(alpha, beta-methylene) diphosphate; ALs: autolysosomes; AMPK: AMP-activated protein kinase; APOA1: apolipoprotein A1; APs: autophagosomes; ATG5: autophagy related 5; ATV: atorvastatin; AVs: autophagic vacuoles; CD: chow diet; CDL: clopidogrel; CQ: chloroquine; DAPI: 4ʹ,6-diamidino-2-phenylindole; dbcAMP: dibutyryl-cAMP; DIL-oxLDL: dioctadecyl-3,3,3,3-tetramethylin docarbocyanine-oxLDL; EIF4EBP1/4E-BP1: eukaryotic translation initiation factor 4E binding protein 1; EVG: elastic van gieson; HE: hematoxylin-eosin; HDL: high-density lipoprotein; HFD: high-fat diet; KEGG: Kyoto Encyclopedia of Genes and Genomes; LDL-c: low-density lipoprotein cholesterol; LDs: lipid droplets; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; Masson: masson trichrome; MCPT: maximal carotid plaque thickness; MK2206: MK-2206 2HCL; NBD-cholesterol: 22-(N-[7-nitrobenz-2-oxa-1,3-diazol-4-yl] amino)-23,24-bisnor-5-cholen-3β-ol; OLR1/LOX-1: oxidized low density lipoprotein receptor 1; ORO: oil Red O; ox-LDL: oxidized low-density lipoprotein; SQSTM1/p62: sequestosome 1; TEM: transmission electron microscopy; TIC: ticagrelor; ULK1: unc-51 like autophagy activating kinase 1; VSMCs: vascular smooth muscle cells</p>…”

DataSheet_1_Targeting Mcl-1 by AMG-176 During Ibrutinib and Venetoclax Therapy in Chronic Lymphocytic Leukemia.pdf by Xue Yi (12115359)

“…<p>B-cell receptor (BCR) signaling pathway and Bcl-2 family prosurvival proteins, specifically Bcl-2 and Mcl-1, are functional in the pathobiology of chronic lymphocytic leukemia (CLL). …”

A Long-Chain Flavodoxin Protects <i>Pseudomonas aeruginosa</i> from Oxidative Stress and Host Bacterial Clearance by Alejandro J. Moyano (186752)

“…Overexpression of FldP in a <i>mutT</i>-deficient <i>P. aeruginosa</i> strain decreased H₂O₂-induced cell death and the hypermutability caused by DNA oxidative damage. …”

DataSheet3.CSV by Hsuan Chou (4995500)

Abhd15 expression is tightly connected to apoptosis. by Evelyn Walenta (484072)

“…The protein expression of the pro-survival regulator BCL-2 was decreased, while the protein level of the pro-apoptotic regulator BAX increased. …”

Molecular Understanding of Growth Inhibitory Effect from Irradiated to Bystander Tumor Cells in Mouse Fibrosarcoma Tumor Model by Sejal Desai (841856)

DataSheet1.xlsx by Hsuan Chou (4995500)

Tissue immunofluorescent staining supports conclusions from RNA-seq studies shown in Fig 3. by Deli Liu (694079)

“…(C) Tumor 404 has significantly decreased 5-methylcytosine (5mC) staining and somewhat decreased acetyl-H4 staining (AcH4), compared to tumor 465. …”

Numerical Simulation on the Radar Cross Section of Variable-Sweep Wing Aircraft by Shichun Chen (6137399)

“…The results of mathematical statistics and comparative analysis show that: (i) the RCS peak value in the head direction of the aircraft decreases non-linearly with the sweep angle of the wing's leading edge; (ii) the azimuth angle corresponding to one of the peak values of the aircraft's RCS is equal to the leading edge's sweep angle; (iii) when the leading edge's sweep angle is 33º, the arithmetic average value of the RCS values in the head direction of the aircraft is 0.644% of the average value when the sweep angle is 0º; (iv) the larger the sweep angle is, the lower the probability that the aircraft is detected.…”

DataSheet_1_Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect.pdf by Ying Huang (53474)

“…A clinically relevant approach using donor T cells treated with a small molecule inhibitor of glycolysis, 2-Deoxy-D-glucose ex vivo, further demonstrated protection from tumor development. …”

Effect of electroless bath composition on the mechanical, chemical, and electrochemical properties of new NiP-C 3 N 4 nanocomposite coatings by Fayyad E.M.

“…An electroless bath of 0.5 g L−1 C3N4 offered a nanocomposite coating with the highest microhardness and superior corrosion resistance. …”
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Evaluation of the inhibition performance of piperazine-based polyurea towards mild steel corrosion: The role of keto-enol tautomerization by Abdulazeez, Ismail

“…The presence of PUCorr at 100 ppm decreases the corrosion current density from 30.3 to 3.05 μA/cm2 in 0.5 M NaCl at room temperature, exhibiting a remarkable inhibition efficiency of 94.5%. …”
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Identification of TADs in multiple resolutions. by Koon-Kiu Yan (87042)

“…The median TADs size decreases from 3 Mbp to 300 kbp as the resolution increases from 0.75 to 3.5. …”

Morphology and patterns of gene expression during elbow and knee regeneration. by Jangwoo Lee (297944)

“…Expression of tenascin-C remained high in the perichondrium at later stages of regeneration (5 weeks post-amputation), but decreased in the regions where the joints were regenerated (H). …”

Expression of TAP38 in <i>tap38</i> mutant, TAP38 overexpressor, and WT plants. by Mathias Pribil (254032)

“…(C) Thylakoid membranes of WT plants exposed to different light conditions (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000288#pbio-1000288-g005" target="_blank">Figure 5</a>) were separated by SDS-PAGE. …”

LLL12 and Stattic inhibited STAT3 expression. by Li Lin (111038)

“…(<b>C</b>) LLL12 inhibited the expression of STAT3 downstream target genes and ALDH1 in ALDH⁺ subpopulation of breast cancer cells. (<b>D</b>) STAT3 ShRNA decreased the STAT3 expression and STAT3 phosphorylation, and inhibited tumor growth in ALDH⁺ MDA-MB-231 breast cancer stem-like cells.…”

The best responses of the fish and of the manager. by Monica Salvioli (10011163)

“…For this example, <i>R</i> = 4, <i>z</i> = 3, <i>d</i> = 0.2, <i>c</i> = 5 and <i>s</i> = 1. The ESS size of the fish increases with juvenile growth rate and decreases with harvesting rate, the optimal harvesting rate for the manager increases with juvenile growth rate. …”

Summary of results: differences from Control/Control group. by Esther Castillo-Gómez (191228)

“…<p>No statistically significant differences ( = ) or statistically significant increases (↑) or decreases (↓) on the parameters measured, when compared with control/control group following the appropriate statistical analysis (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029516#s2" target="_blank">materials and methods</a> section); p<0.05 (*), p<0.01 (**), p<0.001 (***).…”

Survival and engraftment of transplanted ADSCs. by Jianfeng Liu (122580)

“…(C) Confocal laser microscopic images of ADSCs (fluc-mRFP), cardiomyocytes (cTnI, red florescence) and DAPI (blue fluorescence) at 2 weeks after transplantation (n = 4/group). Scale bars = 50 µm (D) Quantitative analysis of the ratio of fluc and mRFP double-positive cells. …”

NEDD9 regulates Vimentin and E-cadherin expression. by Ni Sima (460417)

“…Results of Transwell assay showed that decreased cell invasion (C) and migration (D) by shRNA of NEDD9 were increased by siRNA against E-cadherin in SiHa and HeLa cells. …”