Image3_Nitazoxanide, an Antiprotozoal Drug, Reduces Bone Loss in Ovariectomized Mice by Inhibition of RANKL-Induced Osteoclastogenesis.tif by Chang-hong Li (11816780)

“…In vivo, ovariectomized mice were treated with 50, 100 and 200 mg/kg/d NTZ for 3 months. NTZ (100 mg/kg/d) administration markedly reduced ovariectomy-induced bone loss by suppressing osteoclast activity. …”

A deletion bias creates the appearance of conserved site spacing. by Richard W. Lusk (106685)

“…However, the deletion bias, on average, ratchets sites together over time, correlating any two pairs of sites' evolution. (C–E) After starting 30 (C), 50 (D), or 100 (E) base pairs apart at a speciation event, orthologous pairs of sites are subjected to a simple test of spacing conservation. …”

DataSheet1_Nitazoxanide, an Antiprotozoal Drug, Reduces Bone Loss in Ovariectomized Mice by Inhibition of RANKL-Induced Osteoclastogenesis.docx by Chang-hong Li (11816780)

“…In vivo, ovariectomized mice were treated with 50, 100 and 200 mg/kg/d NTZ for 3 months. NTZ (100 mg/kg/d) administration markedly reduced ovariectomy-induced bone loss by suppressing osteoclast activity. …”

A Genome-Wide Screen for Modifiers of [<i>PSI</i>⁺] Induction by Jens Tyedmers (220526)

“…The prion domain (amino acids 1–253) of <i>SUP35</i> was fused to YFP with an 8–amino acids (GSRVPVEK) linker (PD-YFP). Three different 74D-694 [<i>RNQ</i>⁺] derivatives express PD-YFP from genomic copies under control of the galactose-inducible promoter. …”

Embryonic Morphogen Nodal Promotes Breast Cancer Growth and Progression by Daniela F. Quail (123286)

“…<em>In vitro</em>, using Trypan Blue exclusion assays, Western blot analysis of phosphorylated histone H3 and cleaved caspase-9, and real time RT-PCR analysis of <em>BAX</em> and <em>BCL2</em> gene expression, we demonstrate that Nodal promotes expansion of breast cancer cells, likely via a combinatorial mechanism involving increased proliferation and decreased apopotosis. …”

Data_Sheet_1_Trends in Nutritional Biomarkers by Demographic Characteristics Across 14 Years Among US Adults.docx by Wenjie Wang (413433)

“…Across 14 years, increased trends were found in red blood cell (RBC) folate, serum vitamin B₁₂, vitamin D and albumin, the prevalence of iodine deficiency, vitamin B₆ inadequacy, and hypophosphatemia, whereas decreased trends were observed in serum vitamin E, phosphorus, total calcium, total protein, apolipoprotein B (Apo B), low-density-lipoprotein cholesterol (LDL-C), triglyceride (TG), total cholesterol (TC), blood lead, cadmium, mercury, and the prevalence of vitamin C deficiency, vitamin D inadequacy, iodine excess, and dyslipidemia with elevated LDL-C, TC, TG, and lowered HDL/LDL. …”

Data_Sheet_1_β-Carboline Alkaloids From the Deep-Sea Fungus Trichoderma sp. MCCC 3A01244 as a New Type of Anti-pulmonary Fibrosis Agent That Inhibits TGF-β/Smad Signaling Pathway.d... by Meng-Jiao Hao (13166622)

“…The chemical structures of these compounds were elucidated based on their HRESIMS, 1D and 2D NMR spectra, optical rotation calculation, and comparisons with data reported in the literature. …”

Image1_Nitazoxanide, an Antiprotozoal Drug, Reduces Bone Loss in Ovariectomized Mice by Inhibition of RANKL-Induced Osteoclastogenesis.tif by Chang-hong Li (11816780)

“…In vivo, ovariectomized mice were treated with 50, 100 and 200 mg/kg/d NTZ for 3 months. NTZ (100 mg/kg/d) administration markedly reduced ovariectomy-induced bone loss by suppressing osteoclast activity. …”

DataSheet1_Nitazoxanide, an Antiprotozoal Drug, Reduces Bone Loss in Ovariectomized Mice by Inhibition of RANKL-Induced Osteoclastogenesis.docx by Chang-hong Li (11816780)

“…In vivo, ovariectomized mice were treated with 50, 100 and 200 mg/kg/d NTZ for 3 months. NTZ (100 mg/kg/d) administration markedly reduced ovariectomy-induced bone loss by suppressing osteoclast activity. …”

Table 1_Integrating single-cell RNA-seq, bulk RNA-seq and network pharmacology reveals protective effect of salidroside in peritoneal dialysis-associated peritoneal fibrosis.docx by Shuting Li (6552)

“…<p>Salidroside (2- (4-Hydroxyphenyl) ethyl β-D-glucopyranoside, SAL) is a bioactive compound present in Rhodiola rosea L., exhibiting diverse pharmacological properties such as anti-inflammatory and anti-fibrotic effects. …”

Neuron-Specific Deletion of Peroxisome Proliferator-Activated Receptor Delta (PPARδ) in Mice Leads to Increased Susceptibility to Diet-Induced Obesity by Heidi E. Kocalis (142111)

Video_5_The Importance of Inter-Species Variation in Traumatic Brain Injury-Induced Alterations of Microglial-Axonal Interactions.MP4 by Karen M. Gorse (5772377)

“…The physical interactions between Iba-1+ microglia and either normal MBP+ myelinated fibers or APP+ injured axonal swellings in the thalamus were assessed following injury or sham via quantitative image analysis of 3D confocal micrographs. The results indicated that the physical interactions between microglia and injured axonal swellings decreased by nearly half in rats 6 h following cFPI but was consistent with sham control at 1 day post-cFPI. …”

DataSheet_1_Methotrexate Inhibits T Cell Proliferation but Not Inflammatory Cytokine Expression to Modulate Immunity in People Living With HIV.pdf by Michael L. Freeman (164199)

Image_1_Xanthohumol Inhibits the Growth of Keratin 18-Overexpressed Esophageal Squamous Cell Carcinoma in vitro and in vivo.TIF by Shuying Yin (8858804)

“…Xanthohumol also induced apoptosis and cell cycle arrest at G1 phase which was associated with the modulation of expression of related makers including cyclin D1, cyclin D3, and cleaved-PARP, Bcl-2, cytochrome c and Bax. …”

Rab6/p230-positive vesicular tubular carriers increase in LPS-activated RAW 264.7 macrophages. by Massimo Micaroni (319738)

“…The values represents means ± SD of eight cells observed for those expressing Rab6a–GFP (green), p230(GRIP)–mCherry (red), Rab6a–GFP and p230(GRIP)–mCherry (striped), in control or LPS-activated RAW264.7 macrophages. (D) Cells co-transfected with Rab6a(T27N)–GFP and p230(GRIP)–mCherry revealed a decreased level of p230-positive vesicular/tubular carriers. …”

Video_3_The Importance of Inter-Species Variation in Traumatic Brain Injury-Induced Alterations of Microglial-Axonal Interactions.MP4 by Karen M. Gorse (5772377)

“…The physical interactions between Iba-1+ microglia and either normal MBP+ myelinated fibers or APP+ injured axonal swellings in the thalamus were assessed following injury or sham via quantitative image analysis of 3D confocal micrographs. The results indicated that the physical interactions between microglia and injured axonal swellings decreased by nearly half in rats 6 h following cFPI but was consistent with sham control at 1 day post-cFPI. …”

Type III IFNs present delayed transcriptional activity compared to type I IFNs. by Kalliopi Pervolaraki (6019664)

“…<p>(A-D) Human colon organoids were treated with type I IFN (β) (2,000 RU/mL equivalent 0.33 nM) or type III IFN (λ1−3) (300 ng/mL equivalent 13.7 nM) for 3, 6, 12 or 24 hours and the kinetic pattern of expression of the 65 significantly up-regulated ISGs were analyzed by qRT-PCR in triplicates. …”

Data_Sheet_1_The Importance of Inter-Species Variation in Traumatic Brain Injury-Induced Alterations of Microglial-Axonal Interactions.pdf by Karen M. Gorse (5772377)

“…The physical interactions between Iba-1+ microglia and either normal MBP+ myelinated fibers or APP+ injured axonal swellings in the thalamus were assessed following injury or sham via quantitative image analysis of 3D confocal micrographs. The results indicated that the physical interactions between microglia and injured axonal swellings decreased by nearly half in rats 6 h following cFPI but was consistent with sham control at 1 day post-cFPI. …”

The PHD Finger of Human UHRF1 Reveals a New Subgroup of Unmethylated Histone H3 Tail Readers by Nada Lallous (196880)

“…On the other hand, the recognition appears to rely on histone H3R2, which fits snugly into a groove on the protein and makes tight interactions with the conserved aspartates D334 and D337. …”

Table1_Nitazoxanide, an Antiprotozoal Drug, Reduces Bone Loss in Ovariectomized Mice by Inhibition of RANKL-Induced Osteoclastogenesis.docx by Chang-hong Li (11816780)

“…In vivo, ovariectomized mice were treated with 50, 100 and 200 mg/kg/d NTZ for 3 months. NTZ (100 mg/kg/d) administration markedly reduced ovariectomy-induced bone loss by suppressing osteoclast activity. …”