Expression levels of myosin heavy chain and AMPK-PGC-1α pathway in the skeletal muscles. by Shinichiro Yamada (3600374)

“…<p>The mRNA expression levels of <i>MYH1</i> (encoding MHC type IIx), <i>MYH2</i> (encoding MHC type IIa), and <i>MYH7</i> (encoding MHC type I) normalized to β2-microglobulin levels in the intercostal muscles of SBMA (<i>n</i> = 5) and ALS (<i>n</i> = 5) subjects (A–C). …”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…Current treatments, such as teriparatide, boost bone formation but also elevate resorption, limiting their long-term effectiveness. We discovered 3-butyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-<i>d</i>]pyrimidin-4(3<i>H</i>)-one <b>(5cc)</b>, an orally active phosphodiesterase-1 (PDE1) inhibitor aimed at restoring this balance. …”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…Current treatments, such as teriparatide, boost bone formation but also elevate resorption, limiting their long-term effectiveness. We discovered 3-butyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-<i>d</i>]pyrimidin-4(3<i>H</i>)-one <b>(5cc)</b>, an orally active phosphodiesterase-1 (PDE1) inhibitor aimed at restoring this balance. …”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…Current treatments, such as teriparatide, boost bone formation but also elevate resorption, limiting their long-term effectiveness. We discovered 3-butyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-<i>d</i>]pyrimidin-4(3<i>H</i>)-one <b>(5cc)</b>, an orally active phosphodiesterase-1 (PDE1) inhibitor aimed at restoring this balance. …”

Complete ELICIT TAC data. by Godfrey Guga (12152390)

“…We tested 5,479 stool samples at time points across the study for 34 enteropathogens using quantitative PCR.…”

ELICIT TAC data dictionary. by Godfrey Guga (12152390)

“…We tested 5,479 stool samples at time points across the study for 34 enteropathogens using quantitative PCR.…”

Early Stages of Sea-Level Rise Lead To Decreased Salt Marsh Plant Diversity through Stronger Competition in Mediterranean-Climate Marshes - Fig 2 by Akana E. Noto (3623366)

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study by Lauren E. Mokry (787325)

“…MR analyses found that each genetically determined one-standard-deviation decrease in log-transformed 25OHD level conferred a 2.0-fold increase in the odds of MS (95% CI: 1.7–2.5; <i>p</i> = 7.7 × 10⁻¹²; <i>I</i>² = 63%, 95% CI: 0%–88%). …”

Neither ASICs nor TRPV1 activities are affected by depletion of PI(3,4,5)P₃. by Hae-Jin Kweon (525019)

“…<p>(A) CF-PTEN is rapidly recruited to the plasma membrane anchor LDR by dimerization of FRB and FKBP upon addition of rapamycin, and the PD domain of CF-PTEN specifically dephosphorylates PI(3,4,5)P₃ to PI(4,5)P₂. …”

Loss of SID-1 and/or SID-3 functionality decreases DA neurodegeneration and improves DA neuron function. by Anthony L. Gaeta (13272609)

Intraperitoneal hinokitiol injection does not decrease the number of live bacteria in BALF. by Toshihito Isono (8587668)

PrioV3 and ICSM35 antibodies inhibit accumulation of PrP^Sc in ScN2a cells. by Daryl Rhys Jones (351314)

“…<p>ScN2a cells were incubated for 24 hours at 37°C (5% CO₂) with 1 or 25 µg PrioV3 and ICSM35. 25 µg NCS (Normal camel serum), and BRIC126-treated as well as untreated cells were also included. …”

LARP1 regulates Netrin-1 microsomal translation. by Marie-Laure Plissonnier (337713)

“…LARP1 depletion decreases the expression of Netrin-1 protein in microsomes in Huh7.5 cells. …”

<i>In vivo</i> HDL protects the heart from IR injury via STAT3 activation. by Sarah Pedretti (703288)

SEM images (at 100x) of (a-1) polished P110 CS and corroded in 15% HCl for 6h (a) in the absence and presence of (b) 5, (c) 6a and (d) 6b. by Ghadeer Mubarak (21567569)

Lack of Skeletal Muscle IL-6 Affects Pyruvate Dehydrogenase Activity at Rest and during Prolonged Exercise - Fig 1 by Anders Gudiksen (3165363)

Effects of silencing KCa1.1 or Kir2.1 on cell migration in human cardiac c-kit⁺ progenitor cells. by Ying-Ying Zhang (586673)

Characterization of LNCaP cell growth cultured within biomimetic hydrogels in normal growth media, RPMI and 10% FBS. by Shirly Sieh (139080)

“…<p>(A) Growth curves of LNCaP cells over 7 days for 2D cultures (left) and 28 days for 3D cultures (right) in normal growth media measured by total DNA content (mean ± SE). …”

OPTN degrades GSK3β via activating LC3-mediated autophagy. by Xiao Chen Shi (8611887)

Epidermal Growth Factor Receptor-Dependent Mutual Amplification between Netrin-1 and the Hepatitis C Virus by Marie-Laure Plissonnier (337713)

“…Knockdown and forced expression experiments identified the receptor uncoordinated receptor-5 (UNC5A) as an antagonist of the Netrin-1 signal, though it did not affect the death of HCV-infected cells. …”