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A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation...
Published 2019“…The molecular interaction study also revealed that the co-crystallized AKT1 inhibitor N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo [4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide (12j) exhibited a better interaction with native AKT1 compared with the E17K mutant AKT1 protein, whereas, Akti-1/2 exhibited the opposite effects, i.e., a better interaction with the E17K mutant AKT1 than the native AKT1. …”
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Coral reef resilience differs among islands within the Gulf of Mannar, southeast India, following successive coral bleaching events
Published 2021“…Overall, between 2005 and 2017 reefs had a simultaneous decrease in relative coral cover (avg. = ? …”
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Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function.
Published 2020“…The negatively-charged side chains of two aspartate residues (D179 and D180) within the β8-β9 loop are crucial for the N-terminal inter-subunit interaction. …”
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Effects of rutile-TiO2 nanoparticles on accelerated weathering degradation of poly(Lactic Acid)
Published 2020“…The effect of accelerated weathering on poly(lactic acid) (PLA) and a PLA nanocomposite with rutile titanium (IV) dioxide (rutile-TiO2) was investigated. The accelerated weathering test applied consecutive steps of ultraviolet (UV) (at 340 nm and 0.76Wm-2 irradiance) and moisture at 50 C for 2000 h, following the ASTM D4329 standard. …”
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Evaluation of antibody response in symptomatic and asymptomatic covid-19 patients and diagnostic assessment of new IgM/IgG elisa kits
Published 2021“…This study aims to study the immune response and evaluate the performances of four new IgM and five IgG enzyme-linked immunosorbent assay (ELISA) kits for detecting anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies against different antigens in symptomatic and asymptomatic coronavirus disease 2019 (COVID-19) patients. …”
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RF-based drone detection and identification using deep learning approaches: An initiative towards a large open source drone database
Published 2019“…Averaged accuracy has decreased from 99.7% for the first DNN (2-classes), to 84.5% for the second DNN (4-classes), and lastly, to 46.8% for the third DNN (10-classes). …”
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RF-based drone detection and identification using deep learning approaches: An initiative towards a large open source drone database
Published 2019“…Averaged accuracy has decreased from 99.7% for the first DNN (2-classes), to 84.5% for the second DNN (4-classes), and lastly, to 46.8% for the third DNN (10-classes). …”
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Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells
Published 2020“…The combination of cisplatin and BI-D1870 also resulted in the inhibition of LC3 II to LC3 I expression when compared to BI-D1870. …”
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Co-doped zigzag graphene nanoribbon based gas sensor for sensitive detection of H2S: DFT study
Published 2021“…Moreover, the adsorption distance (D) between H2S and Cu/Zn-ZGNR decreased remarkably to 2.23 Å and an S–Cu bond was generated. …”
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Biochar of spent coffee grounds as per se and impregnated with tio2: Promising waste-derived adsorbents for balofloxacin
Published 2021“…Surface morphology, functional moieties, and thermal stabilities of both adsorbents were scrutinized using SEM, EDS, TEM, BET, FTIR, Raman, and TG/dT analyses. BET analysis indicated that the impregnation with TiO2 has increased the surface area (50.54 m2 /g) and decreased the pore size and volume. …”
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Improving Concrete Durability by Using Optimized Aggregate Gradation and Reducing Cement Content
Published 2020“…The main findings from this study are as follows: (1) The cementitious content of typical Florida pavement and structural concrete can be reduced by as much as 10 to 15% without loss in workability of the fresh concrete, and without decreasing the strength and durability of the hardened concrete. (2) Portlandlimestone cement (Type IL) can be used as a substitute for ordinary Portland cement (Type I/II). (3) The OAG technique can be used to efficiently reduce the cementitious content of the concrete mixes and to improve their performance."…”
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Unraveling the future productivity burden of cardiovascular disease in Qatar: Investigating the modifiable risk factors control in type 2 diabetes
Published 2025“…However, implementing interventions to decrease the T2D incidence, lower SBP, reduce the number of smokers, and improve the total cholesterol could yield gains of 200,408, 198,173, 194,725, and 113,462 PALYs, respectively. …”
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Accelerated weathering effects on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and PHBV/TiO2 nanocomposites
Published 2020“…The effect of accelerated weathering on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and PHBV-based nanocomposites with rutile titanium (IV) dioxide (PHBV/TiO2) was investigated. The accelerated weathering test applied consecutive steps of UV irradiation (at 340 nm and 0.76 W m-2 irradiance) and moisture at 50 C following the ASTM D4329 standard for up to 2000 h of exposure time. …”
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Inner sphere oxidation of N,N′-ethylenebis(isonitrosoacetyleacetoneimine)copper(II) by N-bromosuccinimide in aqueous weakly acidic solutions
Published 2013“…The overall rate law is represented by Eq. (2) where [CuIL]t and K 1 represent the total copper(II) complex concentration and the pre- equilibrium formation constant, respectively. d [CuL+]/dt = {(ko+k₁ [H+]) [SBr] [CuL]}/(1 + K₁ [SBr])…”
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Beta-caryophyllene exhibits anti-proliferative effects through apoptosis induction and cell cycle modulation in multiple myeloma cells
Published 2021“…These effects were counteracted by AM630 co-incubation, thus confirming that BCP’s mechanism of action is mainly related to CB2R modulation. A decrease in β-catenin regulated the impaired cell cycle and especially promoted cyclin D1 and CDK 4/6 reduction. …”
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Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling.
Published 2019“…SNG treatment of MM cells leads to down-regulation of the anti-apoptotic proteins including cyclin D, Bcl-2, Bclxl, and XIAP. In addition, it also upregulates pro-apoptotic protein, Bax. …”
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