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step decrease » sizes decrease (Expand Search), teer decrease (Expand Search), we decrease (Expand Search)
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GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age.
Published 2021“…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”
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Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver.
Published 2021“…(A-B) GCase levels as assessed by the CBE/4-MU method are significantly decreased in the het <i>GBA1</i> D409V KI mice at 5 months of age in both brain (A) and liver (B). …”
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AS021 activity and Satb2 expression decrease within deep layers at postnatal stages.
Published 2011“…(E–G″′) Immunostaining for Satb2 (red), Ctip2 (blue), and βgal (green) in coronal sections of P2 AS021-lacZ brains reveals a strong decrease of Satb2 staining specifically in deep layers. …”
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Suppression of APN/CD13 expression by siRNA induced a marked decrease in migratory potential of ES-2 cells
Published 2011“…D; The level of migration of ES-2 cells transfected with si-CD13 relative to the control was 33%. …”
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NaSal increased the excitability of 5-HTergic neurons, but decreased that of GABAergic neurons in the DRN of the ChR2 transgenic mouse.
Published 2015“…(B) Sample recordings from a 5-HTergic neuron showing that NaSal increased voltage responses to a series of hyperpolarizing currents (-10 to -60 pA, -10 pA/step, duration: 500 ms). …”
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Exposure to low CO<sub>2</sub> levels decreases ER cholesterol levels.
Published 2023“…<b>(B)</b> Bioluminescence recordings from the different conditions as depicted in <b>(A)</b>, the arrow indicates the time CO<sub>2</sub> was shifted from 5% to 1% (mean ± SE, <i>n</i> = 4 biological replicates per condition, AUC for 0 mM 0.34 ± 0.007, 1.59 ± 0.004 (<i>P</i> < 0.0001), 0.5 mM 1.00 ± 0.023, 2.68 ± 0.04 (<i>P</i> < 0.0001), 1 mM 1.66 ± 0.07, 3.34 ± 0.04 (<i>P</i> < 0.0001), 3 mM 2.06 ± 0.02, 2.79 ± 0.07 (<i>P</i> < 0.0001), 5 mM 2.02 ± 0.05, 2.43 ± 0.06 (<i>P</i> < 0.002), 7 mM 1.85 ± 0.01, 1.77 ± 0.02 (<i>P</i> < 0.02) two-sided Student’s <i>t</i> test). …”
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Casein kinase 1.2 depletion decreases ZC3H11 phosphorylation.
Published 2016“…Procyclic cells expressing in situ tagged V5-CK1.2, with a tetracycline-inducible stem-loop RNAi construct, were induced with tetracycline (200g/ml). …”
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Stimulation of α2-adrenergic receptors inhibits hippocampal precursor activity and decreases neurogenesis.
Published 2014“…<p>(A) Treatment of hippocampal precursor cells with α2-adrenergic receptor agonist at 10 uM significantly decreased neurosphere formation compared to the control. …”
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