Functional annotation analysis of proteins with altered phosphorylation in rHla-treated 16HBE14o- and S9 cells. by Erik Richter (551398)

“…KEGG pathways with statistically noticeable number of proteins with altered phosphorylation following rHla-treatment for 2 h. The dotted vertical line indicates the cut-off for significant enrichment (Benjamini-Hochberg corrected p-value ≤0.01). …”

Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model by Bhuvanesh Dave (147341)

Construction of ORF48 deletion mutants using the BAC16 system. by Beatriz H. S. Veronese (19486051)

“…Deletion of the ORF48 coding region (1.2kb) results in a decreased size of a band from 25,693bp to 24,484bp, as indicated by red arrows. …”

The effects of eNpHR-mediated inhibition of PCs in lobule IXab. by Tadashi Tsubota (210705)

“…Black line indicates average, and gray lines indicate average ± SEM. n = 9 units, 2 rats. (D) A sample raw trace of arterial blood pressure around the time of photoinhibition. …”

Regulation at non-saturating levels of TF. by Md Zulfikar Ali (11965544)

“…(D-E) This phenomenon persists when examining autoregulatory genes. …”

CFSE-labeled PBMCs display yellow-green fluorescence. by Guang-ping Ruan (3955208)

“…All the cells are labeled with yellow-green fluorescence. D. The expression of the pluripotency-related genes <i>NANOG</i>, <i>OCT4</i>, and <i>SOX2</i> was significantly increased after induction, whereas the expression of the somatic cell gene <i>LMNA</i> was decreased after induction. …”

LNA-anti-miR-182 and -381 had anticancer effects on glioma cells and subcutaneously transplanted tumors in nude mice. by Hailin Tang (129690)

“…(B) LNA-mediated miR-182 and -381 silencing blocked cell cycle progression in the G0/G1 phase, induced pRb expression, and decreased E2F3 expression. (C) <i>BRD7</i> silencing inhibited the proliferation of glioma cells and blocked the cell cycle in the G0/G1 phase. * <i>p</i><0.05 compared with control (siRNA scrambled). …”

TBr down regulated STAT3 target genes and promoted ubiquitin dependent degradation of activated STAT3. by Anup S. Pathania (657368)

“…(B) HL-60 cells were treated with TBr at 2 and 3 µM concentrations along with the proteasomal inhibitor MG132 (0.07 µM) for 6 h. …”

siRNA knockdown of miR-574-3p target genes and effect on PCa cell viability. by Takeshi Chiyomaru (140914)

“…Cell viability was analyzed by the MTS cell proliferation assay 1, 2 and 4 days after transient transfection. (D) Knockdown of RAC1, EGFR and EP300 significantly inhibits cell migration. …”

Effects of U0126, T0070907, and Pioglitazone hydrochloride (Pio) on NO production in LPS-stimulated RAW264.7 macrophages. by Xiang Li (114679)

“…LPS treated alone) (A and D). PPARγ phosphorylation inhibitor T0070907 strongly suppressed NO release (**<i>p</i><0.01 vs. model) (C), while PPARγ agonist Pio decreased NO secretion (**<i>p</i><0.01 vs. model) (B). …”

HR and NTS neurons activity relationship. by Jenya Kolpakova (3909658)

“…After the peak firing, this neuron activity declined while the HR was still decreasing. <b>B)</b> A 3-D plot shows the difference of the HR reduction-NA between two representative early and late neurons as shown in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0169529#pone.0169529.g004" target="_blank">Fig 4C</a></b>. …”

Individual strings contribute significantly to the functionality of the chosen models. by Anupam Saxena (120438)

“…The intact model (with no string removed) exhibits the least cross validation error. (d) Each string member is removed one at a time from model (iv) and cross validation errors are computed. …”

Regulating Emotions during Difficult Multiattribute Decision Making: The Role of Pre-Decisional Coherence Shifting by Stephanie M. Carpenter (3177762)

Ectopic expression of SABT1 induces EMT and knockdown of SATB1 reverses EMT in established human cancer cell lines. by Feng Wan (565437)

“…The expression of epithelial marker, E-cadherin, was upregulated compared to nontransfected cells and control vector-transfected cells (C and D; *P<0.05;**P<0.001). There were no remarkable changes in the expressions of ZEB1, ZEB2 and Twist, other known inhibitors of E-cadherin, in BIU-87 with enhanced SATB1 expression and T24 cells with reduced SATB1 expression, respectively.…”

FUCCI monitoring during collective cellular migration. by Leo Goldstien (18887011)

“…When transitioning from G1 to S: 1) cdt1 concentration decreases, and with it, the red fluorophore gradually drops; 2) geminin concentration increases as shown by the rise in the green signal; 3) both fluorophores co-fluoresces and the cell appears yellow. …”

The Polymorphic AluYb8 Insertion in the <i>MUTYH</i> Gene is Associated with Reduced Type 1 Protein Expression and Reduced Mitochondrial DNA Content by Wenwen Guo (442622)

“…The polymorphic AluYb8 insertion in the 15^th intron of the <i>MUTYH</i> gene (<i>AluYb8MUTYH</i>) has been shown to associate with an aggregated 8-hydroxy-2′-deoxyguanosine (8-OH-dG) lesion in genomic DNA and to serve as a risk factor for age-related diseases. …”

Quantification of Ki67 Staining in Rat Pulmonary Arteries. by Daniel J. Kass (173086)

“…Images of pulmonary arteries are shown (A) uninjured + vehicle (B) uninjured + fumagillin (C) MCT + vehicle and (D) MCT + fumagillin (Magnification ×400, bar = 20 µm). …”

Multiple endophenotypes exhibited by <i>bbs</i> mutants. by Calvin A. Mok (201207)

“…ANOVA with Tukey, *** p<0.001, n≥15. (D) The body width of <i>bbs</i> mutants was also decreased in comparison to wild-type animals. …”

TRAF4-PIP binding involves lysines K313 and K345. by Adrien Rousseau (332587)

“…Immunodetection of membrane-bound proteins was performed as described in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001726#pbio-1001726-g002" target="_blank">Figure 2C</a>. Mutagenesis of conserved basic residues showed that replacement of lysines 313 and 345 by a glutamic acid decreases and abolishes binding to PIPs, respectively. …”

Female mice missing one <i>TCF8</i> allele gain weight more readily. by Jessica N. Saykally (368303)

“…<p>Mice were weaned to (<b>A</b>) a diet high in fat (60%) or (<b>B</b>) regular chow diet, and body weights (g) of female <i>TCF8 +/−</i> (black line) or WT (gray line) mice were recorded weekly as indicated. n = 8–34 mice per group, with the number of mice decreasing due to sacrifices at 2 and 3 months. (<b>A</b>) Significance calculated by Student's <i>t</i>-test between age-matched groups, using the Bonferroni post-test correction set at p<0.005. …”